Dr. M's Wellness Center

Hepatomegaly: What It Really Means Through a Genomics + Functional Medicine Lens

Fri, 07 Nov 2025 17:26:16 GMT

Hepatomegaly: What It Really Means Through a Genomics + Functional Medicine Lens

“We don’t chase symptoms — we rebuild systems.”

INTRODUCTION — When the Liver Speaks, It Speaks Early

Dr. Wellman, a retired school teacher in his early sixties, never thought much about his liver. It wasn't until a routine check-up revealed an enlarged liver that he started to wonder about his health. This seemingly silent message from one of the body's most crucial organs signaled a change that would lead him on a transformative health journey. Hepatomegaly, while not a diagnosis, was his body's way of alerting him to the shifts happening beneath the surface.

Traditional medicine provides the essential framework for identifying hepatomegaly and ruling out serious structural or pathological conditions. Functional medicine and genomics then explore the metabolic, inflammatory, and genetic patterns that influence liver behavior, prompting a deeper question:

“What is pushing the liver to work harder — and what does that reveal about the system/code beneath the symptom?”

Because hepatomegaly is rarely random.

It’s a downstream expression of upstream biology, including detoxification capacity, genetics, inflammation, hormones, body composition, infections, and even micronutrient status. For example, a nightly glass of wine coupled with low choline genes can exacerbate liver enlargement, illustrating how daily choices interact with our genetic predispositions.

This article breaks it down in the language of systems — not symptoms.

SECTION 1 — The Liver: The Body’s Metabolic Command Center

The liver manages over 500 functions every single day:

Detoxification (Phase I, II, III pathways)
Hormone metabolism
Methylation + epigenetic regulation
Lipid transport + cholesterol balancing
Glycogen storage
Bile production
Immune surveillance
Antioxidant cycling (glutathione system)

When the liver enlarges, one of two things is happening:

✅ 1. Increased workload (adaptive hypertrophy/enlargement)

The liver is trying to keep up with a demand that exceeds its baseline:

High toxic load
Medications
Alcohol
Environmental exposures
Chronic inflammation
Fat accumulation
Microbial endotoxin burden
Biliary congestion (gallbladder dysfunction)
Pancreatic inflammation is blocking biliary flow
Portal pressure changes from spleen or gut inflammation

✅ 2. Structural or inflammatory changes

Fibrosis, congestion, infiltration, infections, or immune dysregulation.

In both scenarios, hepatomegaly is a warning — a metabolic overload alert.

SECTION 2 — The Genomics Perspective: Your Liver's Operating System

Genetic variations determine how efficiently your liver can detox, process hormones, and neutralize oxidative stress . Although these SNPs do not cause hepatomegaly by themselves, they define your vulnerability when lifestyle, diet, or toxicity exceeds capacity. However, just as software can be updated, these genetic predispositions can often be influenced by our choices, highlighting that they are not immutable destinies but modifiable codes.

Key Genomic Pathways Linked to Hepatomegaly

1. Phase I Detox (Cytochrome P450 enzymes)

These convert fat-soluble toxins into reactive intermediates.

CYP1A2 – caffeine + toxins
CYP3A4 – medications, steroids, alcohol
CYP2E1 – alcohol, solvents, industrial chemicals

Fast Phase I and Slow Phase II lead to liver stress and inflammation. So what does this mean in real-world terms? When these detoxification phases are out of balance, substances like acetaminophen can linger in the body up to three times longer, increasing the risk of inflamed tissue and liver damage.

2. Phase II Detox (Conjugation Pathways)

These neutralize and eliminate toxic intermediates:

GSTM1 / GSTT1 deletion → lower glutathione capacity
GSTP1 variants → increased oxidative stress
COMT V158M → slower estrogen + catecholamine clearance
UGT1A1*28 → bilirubin challenges
SULT1A1 variants → impaired hormone metabolism

When Phase II lags, toxic intermediates accumulate → hepatocyte stress → enlargement.

3. Methylation System (MTHFR, MTR, BHMT)

Poor methylation increases:

Homocysteine
Oxidative stress
Estrogen metabolite buildup
Impaired repair of hepatocytes

This slows liver regeneration — a key factor in reversing hepatomegaly.

4. PNPLA3 + TM6SF2 (Fat Accumulation Genes)

These determine your risk for:

Fatty liver
Steatohepatitis
Hepatic inflammation

Carriers of PNPLA3 rs738409 G allele can develop enlargement even with “normal” lifestyle habits.

5. NOD2 + TLR4 (Microbial + Endotoxin Sensitivity)

Heightened response to gut-derived endotoxins → portal inflammation → hepatomegaly.

This is why gut issues and liver enlargement are often inseparable.

SECTION 3 — Functional Medicine View: The 8 Systems and How They Feed the Liver

In the Michael DC systems model, hepatomegaly reflects an imbalance in at least one of the 8 functional systems , often more than one. Consider the case of Jane, a 45-year-old nurse. She experienced symptoms like bloating and fatigue, which prompted her to seek medical advice. Upon analysis, it became evident that her gut-liver axis and hormone system were imbalanced. Jane's diet was heavily laden with refined carbohydrates and lacked fiber, contributing to her gut dysbiosis and endotoxin exposure. Simultaneously, stress and environmental factors were exacerbating her estrogen dominance due to slow COMT function. By adjusting her diet to include more fiber-rich foods, reducing her sugar intake, and implementing stress-reduction techniques, Jane managed to alleviate her symptoms. Additionally, her treatment plan included supplements to support COMT function, such as magnesium and B vitamins, which further helped improve her hormonal balance and liver health.

✅ 1. Gastrointestinal System

The GI tract has the most direct impact on the liver through the gut–liver axis .

Dysbiosis
SIBO
H. pylori
Leaky gut
Endotoxin load
IBS (gas pressure, motility issues → toxin recirculation)
IBD (Crohn’s/UC → cytokine spillover → hepatic inflammation)
Duodenitis/gastritis → impaired bile flow → hepatic congestion

These increase hepatic inflammation through the portal vein.

✅ 2. Detoxification System

Poor Phase I/II balance
Low glutathione
Nutrient deficiencies
Medication overload

The liver swells when detox demand exceeds its detox capacity. To illustrate the importance of detox balance, studies have shown that in patients with NAFLD, there is often a 70% depletion of glutathione, a critical antioxidant that helps protect liver cells from damage.

✅ 3. Hormone System

Estrogen dominance, androgen therapy, thyroid dysregulation — all can enlarge the liver through inflammatory and metabolic shifts.

✅ 4. Immune + Inflammatory System

Low-grade chronic inflammation increases hepatic macrophage activation (Kupffer cells) → liver enlargement.

✅ 5. Metabolic System

Insulin resistance
Obesity
Fatty liver
Pancreatic fat/pancreatitis → bile duct obstruction → hepatic swelling

These are the number one causes of hepatomegaly in the modern world. By using digital health tools such as continuous glucose monitors, individuals can gain real-time insights into their insulin resistance, enabling personalized interventions aligned with metabolic health data. This technology empowers users to track and understand how different lifestyle choices directly impact their liver health, further refining the narrative of functional medicine in a digital age.

✅ 6. Nutrient System

Low levels of:

Choline
Folate
B12
NAC
Glycine
Vitamins A/D/E/K
Omega-3

Directly impair liver repair + detox pathways.

✅ 7. Structural System

Visceral fat compressing the liver
Gallbladder restriction or ductal obstruction
Pancreatic inflammation is blocking the biliary tree
Spleen enlargement increases portal pressure

✅ 8. Circulatory System

Congestive changes (from right-sided heart issues)
Portal hypertension
Splenic backup

It can enlarge the liver due to increased pressure.

SECTION 4 — The 5 Most Common Functional Causes of Hepatomegaly

1. Non-alcoholic fatty liver (NAFLD) — metabolic + genetic

Driven by insulin resistance + PNPLA3/TM6SF2 variants.

2. Estrogen overload

Slow COMT + low methylation → estrogen metabolites accumulate → hepatic congestion.

3. Gut-liver axis dysfunction

Endotoxin exposure from dysbiosis, IBS, IBD, SIBO, gastritis, H. pylori → hepatic inflammation.

4. Toxin burden + slow detox genetics

Environmental chemicals, medications, molds, solvents, and alcohol.

5. Micronutrient depletion

Choline, omega-3, folate, B12, antioxidants.

SECTION 5 — Typical Symptoms Patients Notice

Not everyone feels symptoms, but common ones include:

Right upper quadrant fullness
Bloating after meals
Early satiety
Distension
Intermittent discomfort
Fatigue after eating
Poor alcohol tolerance
Brain fog
High sensitivity to supplements/meds
Pain or pressure worsened by fatty meals (gallbladder)
Pain radiating to the back (pancreatitis)
IBS flares are worsening RUQ pressure
IBD-related fatigue and inflammation burden

These correlate strongly with detox + inflammation overload.

✅ INTERWOVEN NEW SECTION — How Other Organs Influence Hepatomegaly

Gallbladder

Sluggish bile → hepatic congestion
Gallstones → obstruction
Biliary dyskinesia → poor bile release
Post-cholecystectomy → increased hepatic workload

Key genetics: ABCB11, ABCC2, PEMT.

Pancreas

Pancreatitis blocks the common bile duct → liver swelling
Fatty pancreas mirrors fatty liver
Shared metabolic pathways (PNPLA3)

Stomach + Duodenum

Gastritis
Duodenitis
H. pylori
All → cytokine spillover + impaired bile flow → hepatic congestion.

Small Intestine: IBS + SIBO

IBS → motility issues → toxic recirculation
SIBO → endotoxin overload → portal inflammation

Large Intestine: IBD + IBS

IBD → systemic inflammation → hepatic swelling
IBS-C → toxin reabsorption
IBS-D → bile acid dysregulation

Spleen

Splenomegaly increases portal pressure → hepatic engorgement.

Cardiovascular

Right-sided heart dysfunction → hepatic congestion.

Lymphatics

Stagnant lymph flow → slowed hepatic drainage.

Endocrine

Estrogen, thyroid, cortisol, testosterone → all influence liver size.

SECTION 6 — Advanced Functional Testing

✅ Tier 1 (Immediate Panels)

Liver enzymes
Bilirubin
GGT
Lipid panel
Fasting glucose + Insulin + HOMA-IR
Ferritin
CRP/ESR
Viral hepatitis screen
Amylase, lipase (pancreas)
Bilirubin fractionation (biliary issues)

✅ Tier 2 (Expansion)

Hormone panel (Estrogen metabolites + cortisol)
Comprehensive stool test
SIBO breath test
ANA + autoimmune markers
GB ultrasound (gold standard -sludge, stones, EF)
Pancreas imaging, if indicated

✅ Tier 3 (Genomics + Deep Systems)

Liver detox panel (CYP, GST, SULT, COMT, UGT)
PNPLA3/TM6SF2
MTHFR + methylation
Choline metabolism genes (PEMT)
Gut immune SNPs (NOD2, TLR4)
ABCB11 (bile transport)
SPINK1/CTRC/PRSS1 (pancreatitis genetics)

This is where functional medicine shines. We rebuild the system with a personalized approach, recognizing that each patient’s needs may vary. When implementing the protocol, careful consideration is given to customize it for patients with comorbidities or those on multiple medications. This ensures that the care provided is both safe and individualized.

This is where functional medicine shines — we rebuild the system.

PHASE 1 — Reduce Inflammatory Load (2–4 weeks)

Anti-inflammatory diet
Remove alcohol, sugar, and seed oils
Lower endotoxin exposure
Begin NAC + glycine + B-complex
Magnesium glycinate
Omega-3
Light movement daily
Hydration + electrolytes
Soften bile (dandelion, bitters, taurine, choline)
Support the pancreas if it is inflamed (enzymes, low-fat meals)
Reduce IBS/IBD triggers

PHASE 2 — Optimize Detox Pathways (4–8 weeks)

Glutathione support
Bile flow support (TUDCA, milk thistle, dandelion, bitters)
Support Phase II (methylation, sulfation, glucuronidation)
Increase cruciferous vegetables
Add choline (eggs or phosphatidylcholine)
Gallbladder support + biliary drainage
SIBO protocol if positive

PHASE 3 — Repair, Regenerate, Rebuild (8–12+ weeks)

Address gut dysbiosis
Heal intestinal permeability
Complete hormone balancing
Correct micronutrients
Restore mitochondrial function
Reassess liver size
Pancreas recovery if involved
IBD inflammation management

The liver regenerates rapidly when the inputs and the genetic pathways are aligned. It is famously known for its ability to regenerate up to 30% of its mass within just eight weeks. This phenomenal capacity offers tremendous hope for recovery, reinforcing the idea that, with the right interventions, full liver health is achievable.

SECTION 8 — When to Worry

Seek escalation if you see:

Jaundice
Persistent RUQ pain
Fever
Vomiting
Unintentional weight loss
Severe fatigue
Elevated liver enzymes (ALT > 100, AST > 100)
Very high ferritin
Worsening bilirubin
Severe epigastric pain radiating to the back (pancreatitis)
Dark urine + pale stools (biliary obstruction)

CONCLUSION - The Liver Doesn't Fail Overnight

Hepatomegaly is one of the earliest signs the body gives when systems begin to drift out of sync. Functional medicine doesn’t silence that signal. It decodes it and rebuilds the metabolic environment that caused it. Hepatomegaly is not a life sentence. It’s a window of opportunity. With the right genomic insights, nutrient strategy, detoxification optimization, and lifestyle design, the liver can fully regenerate—often faster than patients expect. Because biology isn’t fixed. It’s programmable.

To transform insight into practice, I invite you to choose one upstream lever to adjust this week. Whether it's tweaking your diet, incorporating a new supplement, or simply being more mindful of your daily habits, this small change can set you on the path to improved liver health and overall well-being.

Your health isn’t random. It’s written in code. Every cell in your body carries a script. Your genes don’t just predict your future—they respond to what you eat, how you move, and the choices you make daily. That’s the journey I share in “Understanding Genomics: How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers”.

Order a copy today!

Read the code. Live the design. The rest follows.

Dr. Marios Michael

drmichaelswellness.com

Selected References

Thyroid and PSA: The Crosstalk

1. Thyroid Status Influences PSA Levels

a. Hyperthyroidism Increases PSA:

Shiraishi K, et al. “Serum prostate-specific antigen levels in patients with thyroid dysfunction.” Endocr J. 2003;50(6):821-6.
( Link )
Bahmad HF, et al. “Effect of hyperthyroidism on serum prostate-specific antigen concentrations in men.” Clin Chim Acta. 2017;470:1-4.
( Link )

b. Hypothyroidism Decreases PSA:

Shiraishi K, et al. (same as above)
D’Ambrosio V, et al. "Low serum prostate-specific antigen in patients with hypothyroidism is reversed after thyroid hormone replacement." J Endocrinol Invest. 2005;28(7):654-7.
( Link )

c. Mechanisms:

Benvenga S, et al. “Thyroid hormones and prostate: an intriguing relationship with clinical implications.” Endocrine. 2017;56(2):340-344.
( Link )

2. Functional Medicine Perspectives & Hormone Interplay

a. Thyroid Hormones, Androgens, SHBG:

Gyllenborg J, et al. “Thyroid function and SHBG levels in healthy men.” J Intern Med. 2001;249(2):161-6.
( Link )

Benvenga S, et al. (same as above)

b. Reverse T3, Antibodies, and Cortisol:

Peeters RP, et al. “The metabolism of thyroid hormone: pathways of hormone metabolism and the role of deiodinases.” Endocr Rev. 2006;27(2): 124-192.
( Link )

Chrousos GP. “Stress and disorders of the stress system.” Nat Rev Endocrinol. 2009;5(7):374-81.
( Link )

3. Nutrition & PSA/Thyroid Modulation

a. Mediterranean Diet, Crucifers, Polyphenols, Omega-3:

Schwingshackl L, et al. “Adherence to Mediterranean diet and risk of cancer: an updated systematic review and meta-analysis.” Nutrients. 2017;9(10):1063.
( Link )

Richman EL, et al. “Intakes of meat, fish, poultry, and eggs and risk of prostate cancer progression.” Am J Clin Nutr. 2010;91(3):712-21.
( Link )

Pantuck AJ, et al. “Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer.” Clin Cancer Res. 2006;12(13):4018-26.
( Link )

Henning SM, et al. “Green tea and prostate cancer: From bench to clinic.” Front Nutr. 2017;4:3.
( Link )

Peluso I, et al. “Polyphenols and prostate cancer: molecular mechanisms and clinical evidence.” Nutrients. 2018;10(6):698.
( Link )

b. Omega-3s and Prostate/Thyroid Health:

Li D, et al. “Omega-3 fatty acids in prostate cancer: a meta-analysis.” Nutrients. 2015;7(7):5552-71.
( Link )

Ma J, et al. “Dietary n-3 and n-6 fatty acids and risk of prostate cancer: meta-analysis of prospective studies.” BMJ. 2010;341:c3535.
( Link )

Cholewska P, et al. “Nutritional factors and thyroid autoimmunity.” Nutrients. 2021;13(11):4114.
( Link )

c. Dairy, Red Meat, IGF-1:

Rowlands MA, et al. “Intakes of dairy products and calcium and prostate cancer risk.” Am J Clin Nutr. 2007;86(3):929-37.
( Link )

Allen NE, et al. “Prostate cancer risk and serum insulin-like growth factor (IGF)-I, IGF-II, IGF-binding protein-3, and transforming growth factor-β1.” Br J Cancer. 2000;83(11):1347-53.
( Link )

4. Supplements

a. Vitamin D, Zinc, Selenium:

Travis RC, et al. “Serum vitamin D and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition (EPIC).” Am J Clin Nutr. 2009;89(5): 1394-401.
( Link )

Costello LC, Franklin RB. “Zinc is decreased in prostate cancer: an established relationship of prostate cancer.” J Biol Inorg Chem. 2011;16(1):3-8.
( Link )

Vinceti M, et al. “Selenium for preventing cancer.” Cochrane Database Syst Rev. 2018;1(1):CD005195.
( Link )

b. Curcumin, Saw Palmetto, Pygeum:

Kunnumakkara AB, et al. “Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases.” Br J Pharmacol. 2017;174(11):1325-1348.
( Link )

Kaplan SA, et al. “Saw palmetto in lower urinary tract symptoms.” J Urol. 2004;171(6 Pt 1):2321-5.
( Link )

Wilt TJ, et al. “Pygeum africanum for benign prostatic hyperplasia.” Cochrane Database Syst Rev. 2002;(1):CD001044.
( Link )

Lopresti AL, et al. “Adaptogenic and anxiolytic effects of ashwagandha root extract.” Medicine (Baltimore). 2019;98(37):e17186.
( Link )

5. Lifestyle: Exercise, Weight, Stress, Sleep

Hara N, et al. “Effect of exercise on serum prostate-specific antigen levels in men with prostate cancer.” Prostate. 2004;59(4):372-7.
( Link )

Haqq L, et al. “The impact of weight loss on prostate-specific antigen: a systematic review.” Prostate Cancer Prostatic Dis. 2017;20(1):1-8.
( Link )

Irwin MR, et al. “Sleep loss activates cellular markers of inflammation: sex differences.” Brain Behav Immun. 2010;24(1):54-7.
( Link )

Chrousos GP. “Stress and disorders of the stress system.” (same as above)

6. Botanical and Herbal Allies

Safarinejad MR. “Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study.” J Herb Pharmacother. 2005;5(4):1-11.
( Link )

Henning SM, et al. “Green tea and prostate cancer: From bench to clinic.” (same as above)
Singh CK, et al. “Resveratrol, in cancer prevention and therapy.” Ann N Y Acad Sci. 2011;1215:1-8.
( Link )

Giovannucci E, et al. “Intake of carotenoids and retinol in relation to risk of prostate cancer.” J Natl Cancer Inst. 1995;87(23):1767-76.
( Link )

7. Genomics & Personalized Medicine

Friso S, et al. “A common variant in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation.” J Biol Chem. 2002;277(5):35733-6.
( Link )

Lyssenko V, et al. “Genetic variation in the TCF7L2 gene is associated with increased risk of type 2 diabetes and impaired proinsulin conversion.” Nat Genet. 2007;39(2):218-25.
( Link )

Soerensen M, et al. “Genetic variation in FOXO3 is associated with variation in human longevity.” Aging Cell. 2010;9(4):543-52.
( Link )

✅ DISCLAIMER

This content is for informational and educational purposes only.
It is not intended to provide medical advice, diagnose conditions, treat any disease, or replace individualized guidance from your licensed healthcare provider.

The information presented here reflects general functional medicine and genomics concepts and should not be used as a substitute for medical evaluation , especially in the presence of symptoms such as abdominal pain, jaundice, unexplained weight loss, fever, vomiting, or abnormal liver function test results.

Dr. Marios Michael, cFMP, CNS, cFMP, DAAPM, DC, MUA is a Chiropractic Physician and Functional Medicine Practitioner.
Chiropractic physicians do not diagnose or treat medical conditions outside the chiropractic scope of practice. Any discussion of laboratory findings, liver conditions, hepatomegaly, gastrointestinal disorders, or systemic physiology is for educational interpretation only and is not intended to provide medical management of these conditions.

Statements regarding supplements have not been evaluated by the Food and Drug Administration. Products mentioned are not intended to diagnose, treat, cure, or prevent any disease .

Always consult your primary care physician, gastroenterologist, hepatologist, or other licensed medical doctor before making changes to your diet, medications, supplements, or health regimen—especially if you have known liver, gallbladder, pancreatic, gastrointestinal, or metabolic conditions.

Reading this article does not create a doctor–patient relationship with Dr. Michael or Michael DC, and no personalized health advice is being given.

If you believe you are experiencing a medical emergency, call 911 or seek immediate medical care.

REFERENCES (PubMed/PMC)

Liver physiology & regeneration

Michalopoulos GK. Liver regeneration. J Cell Physiol. 2007;213(2):286-300. PubMed
Michalopoulos GK. Liver regeneration: biological and pathological mechanisms. Nat Rev Gastroenterol Hepatol.2021;18:40-55. PubMed

Cytochrome P450 / Phase I detox
3) Nebert DW, Russell DW. Clinical importance of the cytochromes P450. Lancet. 2002;360:1155-62. PubMed

Phase II conjugation (UGT, SULT, GST) & bilirubin transport
4) Gamage N, et al. Human sulfotransferases and their role in chemical metabolism. Toxicol Sci. 2006;90(1):5-22. PubMed+1
5) Hayes JD, Strange RC. Glutathione S-transferase polymorphisms and their biological consequences. Pharmacol Ther.2000;85(2):135-70. PubMed
6) Oda S, et al. Function, genetic polymorphism, and regulation of UGT1A1. Drug Metab Pharmacokinet. 2013;28:206-18. PubMed
7) Dean L. UGT1A1 and bilirubin (CPIC/PharmGKB resources). Pharmacogenet Genomics. (overview) PMC+1
8) Mao YX, et al. Transport mechanism of human bilirubin transporter ABCC2/MRP2. Nat Commun. 2024;15:3161. PMC
9) Keppler D. Roles of MRP2, MRP3, OATP1B1/1B3 in bilirubin handling. Pflugers Arch. 2014;466:611-28. PubMed

Bile formation & biliary transporters (gallbladder/bile flow)
10) Lam P, et al. BSEP/ABCB11 in bile salt secretion—clinical aspects. Semin Liver Dis. 2010;30:125-33. PubMed
11) Hayashi H, Sugiyama Y. BSEP/ABCB11 trafficking and cholestasis. Hepatol Res. 2013;43:132-48. PubMed
12) Stieger B. BSEP impairment and cholestatic disease (review). Biochim Biophys Acta. 2011;1812:1238-46. PubMed

Hepatic fat genetics (PNPLA3, TM6SF2)
13) Romeo S, et al. PNPLA3 variant confers susceptibility to NAFLD. Nat Genet. 2008;40(12):1461-5. PubMed+1
14) Kozlitina J, et al. TM6SF2 variant affects hepatic triglycerides/VLDL secretion. Nat Genet. 2014;46:352-6. PubMed

Gut–liver axis, SIBO, H. pylori, IBD
15) Augustyn M, et al. SIBO and NAFLD—mechanisms/evidence. Clin Exp Hepatol. 2019;5(3):183-90. PMC
16) Gudan A, et al. Association between SIBO and NAFLD (review). World J Hepatol. 2023;15:705-22. PMC
17) Mantovani A, et al. H. pylori and risk of MASLD/NAFLD (meta-analysis). Liver Int. 2024. PubMed
18) Okushin K, et al. H. pylori infection and liver diseases (review). World J Gastroenterol. 2018;24:3617-25. PMC
19) Fousekis FS, et al. Hepatobiliary manifestations in IBD. Ann Gastroenterol. 2018;31:274-84. PubMed
20) Gaspar R, et al. Liver manifestations and complications in IBD. World J Hepatol. 2021;13:1709-26. PubMed

Pancreas/pancreatitis genetics and biliary–pancreatic interplay
21) LaRusch J, Whitcomb DC. Genetics of pancreatitis (PRSS1, SPINK1, CFTR, CTRC). Curr Opin Gastroenterol.2011;27:467-74. PubMed
22) GeneReviews: PRSS1-related hereditary pancreatitis. NCBI Bookshelf. 2012-update. NCBI
23) Panchoo AV, et al. Hereditary pancreatitis—updated review. World J Clin Pediatr. 2022;11:33-49. PubMed

Portal circulation, spleen/portal pressure, cardio-hepatic
24) Bloom S, et al. Portal hypertension: pathophysiology, diagnosis, management. BMJ. 2015;351:h4597. PubMed
25) Guixé-Muntet S, et al. Pathophysiology & therapy of cirrhotic portal hypertension (update). Nat Rev Gastroenterol Hepatol. 2024;21:238-56. PubMed
26) Xanthopoulos A, et al. Heart failure & liver disease—cardiohepatic interactions. JACC Heart Fail. 2019;7:87-97. PubMed+1
27) Haddadin R, et al. Congestive hepatopathy—review. Cureus. 2024;16:e60264. PMC

Hepatic lymphatics & immune activation (Kupffer/TLR4)
28) Ohtani O, Ohtani Y. Lymph circulation in the liver. Anat Rec (Hoboken). 2008;291:643-52. PubMed
29) Jeong J, et al. Hepatic lymphatic vascular system in health & disease. J Hepatol. 2022;76:1109-23. PMC
30) Rivera CA, et al. TLR4-dependent Kupffer cell activation in liver injury. Am J Physiol Gastrointest Liver Physiol.2007;293:G1134-42. PMC
31) Guo J, et al. TLR4 in liver injury and fibrogenesis. Front Biosci. 2010;2:1356-66. PMC

Nutrients/methylation/choline/glutathione relevant to detox & repair
32) Corbin KD, Zeisel SH. Choline metabolism & NAFLD insights. Curr Opin Gastroenterol. 2012;28:159-65. PubMed+1
33) Spencer MD, et al. Choline deficiency, microbiome & fatty liver in humans. Gastroenterology. 2011;140:976-86. PubMed+1
34) Zeisel SH. Dietary choline deficiency and genomic/mitochondrial effects. Mutat Res. 2012;733:34-42. PubMed
35) Lu SC. Glutathione synthesis—regulation & liver disease. Biochim Biophys Acta. 2013;1830:3143-53. PubMed
36) Vairetti M, et al. Changes in hepatic glutathione in liver diseases (update). Antioxidants (Basel). 2021;10:364. PMC
37) Raghubeer S, Matsha TE. MTHFR C677T in one-carbon metabolism & epigenetics. Nutrients. 2021;13:3186. PMC+1

Omega-3 / NAFLD (optional dietary support evidence)
38) Aziz T, et al. Omega-3 PUFA efficacy in NAFLD (systematic review/meta-analysis). Nutr Rev. 2024;82:156-170. PubMed
39) Sangouni AA, et al. Omega-3 supplementation and fatty liver indices. Clin Nutr ESPEN. 2021;44:484-490. PubMed

Choline/PEMT genetics & NAFLD risk
40) Piras IS, et al. Hepatic PEMT expression decreases with NAFLD severity; PEMT variants linked to risk. Hepatol Commun. 2022;6:2684-2699. PMC
41) Song J, et al. PEMT polymorphism (V175M) and susceptibility to NAFLD. Hum Mol Genet. 2005;14:1249-56. PMC

Pre-Diabetes: A Functional Medicine and Genomics Lens

Tue, 09 Sep 2025 17:17:20 GMT

Pre-Diabetes: A Functional Medicine and Genomics Lens

Why It Matters

Jane, 45, a working mother of two, thinks her doctor’s warning is just “a little sugar problem.” In truth, she’s in the grip of pre-diabetes—a reversible but dangerous stage that affects one in three American adults. If ignored, pre-diabetes quietly advances toward type 2 diabetes, heart disease, and even cognitive decline, robbing years of health and vitality.

In conventional medicine, pre-diabetes is defined by specific laboratory thresholds:

Fasting Plasma Glucose (FPG) : 100–125 mg/dL after at least 8 hours of fasting (impaired fasting glucose).
Oral Glucose Tolerance Test (OGTT) : 140–199 mg/dL two hours after consuming a 75g glucose solution (impaired glucose tolerance).
Hemoglobin A1c (HbA1c) : 5.7%–6.4%, reflecting average blood sugar levels over the past 2–3 months.

These markers identify individuals at significantly increased risk for type 2 diabetes and cardiovascular disease, even when blood sugars are not yet in the diabetic range.

Building on this understanding, a Functional Medicine approach highlights that pre-diabetes extends beyond blood sugar concerns — it reflects a systems-level imbalance involving the gut, liver, adipose tissue, hormones, inflammation, and circadian rhythms.

Building on this understanding, a Functional Medicine approach highlights that pre-diabetes extends beyond blood sugar concerns—it reflects a systems-level imbalance involving the gut, liver, adipose tissue, hormones, inflammation, and circadian rhythms.

Functional Medicine View: Systems in Play

Pancreas & Insulin Response
Early insulin resistance forces the pancreas to overproduce insulin just to keep blood sugar “normal.”
Liver & Metabolism
Non-alcoholic fatty liver—a buildup of fat in the liver not caused by alcohol—is often present. The liver loses its ability to adapt its metabolism as needed, disrupting its role in processing toxins, storing glucose (blood sugar), and balancing fats in the body.
Gut & Microbiome
Dysbiosis (an imbalance of gut bacteria) and leaky gut (when the gut lining becomes more permeable than normal) can trigger inflammation throughout the body, making it easier for insulin resistance to worsen and for appetite regulation to be disrupted.
Adipose Tissue & Hormones
Visceral fat—fat stored deep around internal organs—releases signaling proteins called cytokines (for example, IL-6 and TNF-α) that increase inflammation and interfere with how insulin works in the body.
Sleep & Stress Axis
Disrupted cortisol levels—a stress hormone affected by poor sleep and ongoing stress—can make it harder for the body to manage blood sugar over time.
Thyroid and Hormones Thyroid hormones, sex hormones, and cortisol regulate insulin sensitivity and metabolism—when imbalanced, they contribute to inflammation, disrupt glucose control, and increase the risk of prediabetes.

Science Snapshot

Reversal Potential : Intensive lifestyle interventions can reduce the progression of diabetes by 58% (Diabetes Prevention Program).
Inflammation Link : Higher levels of blood markers, such as high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6), which indicate inflammation, strongly correlate with worsening insulin resistance.
Microbiome Evidence : A greater variety of gut bacteria and higher levels of a beneficial gut microbe called Akkermansia muciniphila are linked to better blood sugar control.
Circadian Rhythm : Misaligned eating patterns (late-night meals, shift work) impair insulin sensitivity even in healthy individuals.

Genomics Brief & Pre-Diabetes

Transitioning from clinical markers to genomics, it's essential to note that your DNA is not your destiny—but it can reveal risk pathways. Functional Medicine leverages epigenetics to intervene early in the disease process.

TCF7L2 → Strongest genetic risk for type 2 diabetes; impacts insulin secretion.
PPARG → Regulates fat metabolism and insulin sensitivity. Some variants increase inflammatory adipokine release.
FTO → Associated with obesity, appetite regulation, and IL-6-driven inflammation.
SLC30A8 → A gene for a zinc transporter protein linked to stress in insulin-producing beta-cells of the pancreas.
MTHFR Variants → Genetic differences that affect methylation (a process essential for many body functions) and levels of homocysteine, which together influence risk of blood vessel problems.
IL6 Variants → Influence baseline cytokine load and systemic inflammation.
TNF-α Polymorphisms → Promote pro-inflammatory states that worsen insulin resistance.
CRP Variants → Alter baseline inflammation, heightening cardiometabolic risk.

Expanded Functional Medicine Blueprint

TEST → TARGET → TRANSFORM

1. Advanced Lab Assessment

Glucose & Insulin Regulation
Fasting glucose, fasting insulin
HbA1c
OGTT with insulin curve
HOMA-IR for insulin resistance mapping

Lipid & Cardiovascular Risk
ApoB, LDL particle size, triglyceride/HDL ratio

Inflammatory & Pro-inflammatory Markers
hs-CRP, IL-6, TNF-α, ferritin
Homocysteine (vascular + methylation marker)

Gut Health
GI-MAP stool test (dysbiosis, leaky gut, LPS)
Zonulin (intestinal permeability)

Nutrient & Hormonal Status
Magnesium, chromium, vitamin D, zinc
Cortisol AM/PM rhythm
Thyroid panel (TSH, free T3/T4, reverse T3)

Lifestyle Interventions

Nutrition
For breakfast, have oatmeal with berries and flaxseeds. Lunch on grilled salmon and greens with olive oil. Enjoy roasted vegetables with quinoa for dinner.

Movement

Incorporate regular movement throughout the day. Start your day with a brisk morning walk, followed by a midday HIIT session to boost your energy in the afternoon, and conclude with an evening yoga session to promote relaxation and recovery.

Sleep & Stress

Conclude your day with calming activities such as mindfulness or reading under soft light. Establish consistent sleep times to support a stable circadian rhythm, promoting restful and restorative sleep.

HRV training, mindfulness, yoga
7–9 hours of restorative sleep aligned with circadian rhythms

3. Targeted Therapeutics

Anti-inflammatory & insulin sensitizers : berberine, curcumin, resveratrol, quercetin, omega-3s
Mitochondrial support : alpha-lipoic acid, CoQ10, carnitine
Gut repair : glutamine, probiotics, prebiotic fibers, polyphenols
Nutrient repletion : magnesium, vitamin D3+K2, zinc, chromium

4. Precision Nutrition (Genomic-Guided)

PPARG variants → respond better to higher monounsaturated fats (olive oil, nuts).
FTO risk → benefit from structured protein intake, satiety-focused nutrition.
TCF7L2 carriers → require tighter glycemic control and disciplined meal timing.

Key Takeaway

Pre-diabetes is as much an inflammatory condition as a glucose disorder. Elevated markers, such as IL-6, TNF-α, hs-CRP, and ferritin, combined with genomic susceptibility, accelerate disease progression. With the right lens of Functional Medicine and the guidance of Genomics, we can intervene early, reset systems, and transform biology before disease sets in.

As an empowering next step, consider scheduling a fasting glucose and IL-6 test this week to take control of your health. Early awareness can be the key to preventing the progression to type 2 diabetes.

Order a copy today!

Read the code. Live the design. The rest follows.

Dr. Marios Michael

drmichaelswellness.com

Selected References

Thyroid and PSA: The Crosstalk

1. Thyroid Status Influences PSA Levels

a. Hyperthyroidism Increases PSA:

Shiraishi K, et al. “Serum prostate-specific antigen levels in patients with thyroid dysfunction.” Endocr J. 2003;50(6):821-6.
( Link )
Bahmad HF, et al. “Effect of hyperthyroidism on serum prostate-specific antigen concentrations in men.” Clin Chim Acta. 2017;470:1-4.
( Link )

b. Hypothyroidism Decreases PSA:

Shiraishi K, et al. (same as above)
D’Ambrosio V, et al. "Low serum prostate-specific antigen in patients with hypothyroidism is reversed after thyroid hormone replacement." J Endocrinol Invest. 2005;28(7):654-7.
( Link )

c. Mechanisms:

Benvenga S, et al. “Thyroid hormones and prostate: an intriguing relationship with clinical implications.” Endocrine. 2017;56(2):340-344.
( Link )

2. Functional Medicine Perspectives & Hormone Interplay

a. Thyroid Hormones, Androgens, SHBG:

Gyllenborg J, et al. “Thyroid function and SHBG levels in healthy men.” J Intern Med. 2001;249(2):161-6.
( Link )

Benvenga S, et al. (same as above)

b. Reverse T3, Antibodies, and Cortisol:

Peeters RP, et al. “The metabolism of thyroid hormone: pathways of hormone metabolism and the role of deiodinases.” Endocr Rev. 2006;27(2): 124-192.
( Link )

Chrousos GP. “Stress and disorders of the stress system.” Nat Rev Endocrinol. 2009;5(7):374-81.
( Link )

3. Nutrition & PSA/Thyroid Modulation

a. Mediterranean Diet, Crucifers, Polyphenols, Omega-3:

Schwingshackl L, et al. “Adherence to Mediterranean diet and risk of cancer: an updated systematic review and meta-analysis.” Nutrients. 2017;9(10):1063.
( Link )

Richman EL, et al. “Intakes of meat, fish, poultry, and eggs and risk of prostate cancer progression.” Am J Clin Nutr. 2010;91(3):712-21.
( Link )

Pantuck AJ, et al. “Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer.” Clin Cancer Res. 2006;12(13):4018-26.
( Link )

Henning SM, et al. “Green tea and prostate cancer: From bench to clinic.” Front Nutr. 2017;4:3.
( Link )

Peluso I, et al. “Polyphenols and prostate cancer: molecular mechanisms and clinical evidence.” Nutrients. 2018;10(6):698.
( Link )

b. Omega-3s and Prostate/Thyroid Health:

Li D, et al. “Omega-3 fatty acids in prostate cancer: a meta-analysis.” Nutrients. 2015;7(7):5552-71.
( Link )

Ma J, et al. “Dietary n-3 and n-6 fatty acids and risk of prostate cancer: meta-analysis of prospective studies.” BMJ. 2010;341:c3535.
( Link )

Cholewska P, et al. “Nutritional factors and thyroid autoimmunity.” Nutrients. 2021;13(11):4114.
( Link )

c. Dairy, Red Meat, IGF-1:

Rowlands MA, et al. “Intakes of dairy products and calcium and prostate cancer risk.” Am J Clin Nutr. 2007;86(3):929-37.
( Link )

Allen NE, et al. “Prostate cancer risk and serum insulin-like growth factor (IGF)-I, IGF-II, IGF-binding protein-3, and transforming growth factor-β1.” Br J Cancer. 2000;83(11):1347-53.
( Link )

4. Supplements

a. Vitamin D, Zinc, Selenium:

Travis RC, et al. “Serum vitamin D and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition (EPIC).” Am J Clin Nutr. 2009;89(5): 1394-401.
( Link )

Costello LC, Franklin RB. “Zinc is decreased in prostate cancer: an established relationship of prostate cancer.” J Biol Inorg Chem. 2011;16(1):3-8.
( Link )

Vinceti M, et al. “Selenium for preventing cancer.” Cochrane Database Syst Rev. 2018;1(1):CD005195.
( Link )

b. Curcumin, Saw Palmetto, Pygeum:

Kunnumakkara AB, et al. “Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases.” Br J Pharmacol. 2017;174(11):1325-1348.
( Link )

Kaplan SA, et al. “Saw palmetto in lower urinary tract symptoms.” J Urol. 2004;171(6 Pt 1):2321-5.
( Link )

Wilt TJ, et al. “Pygeum africanum for benign prostatic hyperplasia.” Cochrane Database Syst Rev. 2002;(1):CD001044.
( Link )

Lopresti AL, et al. “Adaptogenic and anxiolytic effects of ashwagandha root extract.” Medicine (Baltimore). 2019;98(37):e17186.
( Link )

5. Lifestyle: Exercise, Weight, Stress, Sleep

Hara N, et al. “Effect of exercise on serum prostate-specific antigen levels in men with prostate cancer.” Prostate. 2004;59(4):372-7.
( Link )

Haqq L, et al. “The impact of weight loss on prostate-specific antigen: a systematic review.” Prostate Cancer Prostatic Dis. 2017;20(1):1-8.
( Link )

Irwin MR, et al. “Sleep loss activates cellular markers of inflammation: sex differences.” Brain Behav Immun. 2010;24(1):54-7.
( Link )

Chrousos GP. “Stress and disorders of the stress system.” (same as above)

6. Botanical and Herbal Allies

Safarinejad MR. “Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study.” J Herb Pharmacother. 2005;5(4):1-11.
( Link )

Henning SM, et al. “Green tea and prostate cancer: From bench to clinic.” (same as above)
Singh CK, et al. “Resveratrol, in cancer prevention and therapy.” Ann N Y Acad Sci. 2011;1215:1-8.
( Link )

Giovannucci E, et al. “Intake of carotenoids and retinol in relation to risk of prostate cancer.” J Natl Cancer Inst. 1995;87(23):1767-76.
( Link )

7. Genomics & Personalized Medicine

Friso S, et al. “A common variant in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation.” J Biol Chem. 2002;277(5):35733-6.
( Link )

Lyssenko V, et al. “Genetic variation in the TCF7L2 gene is associated with increased risk of type 2 diabetes and impaired proinsulin conversion.” Nat Genet. 2007;39(2):218-25.
( Link )

Soerensen M, et al. “Genetic variation in FOXO3 is associated with variation in human longevity.” Aging Cell. 2010;9(4):543-52.
( Link )

Medical Disclaimer : The information included on this blog is for educational purposes only. It is not intended nor implied to be a substitute for professional medical advice. The reader should always consult his or her healthcare provider to determine the appropriateness of the information for their own situation or if they have any questions regarding a medical condition or treatment plan. Never disregard professional medical advice or delay in seeking it because of something you have read on this blog! Reading the information on this blog does not create a physician-patient relationship.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

References: Supporting Evidence

1. Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346(6):393-403.

2. Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA. 2001;286(3):327-334.

3. Qin J, Li Y, Cai Z, et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature. 2012;490(7418):55-60.

4. Dao MC, Everard A, Aron-Wisnewsky J, et al. Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Gut. 2016;65(3):426-436.

5. Scheer FAJL, Hilton MF, Mantzoros CS, Shea SA. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci U S A. 2009;106(11):4453-4458.

6. Lyssenko V, Jonsson A, Almgren P, et al. Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med. 2008;359(21):2220-2232.

7. Barroso I, Gurnell M, Crowley VE, et al. Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension. Nature. 1999;402(6764):880-883.

8. Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007;316(5826):889-894.

9. Sladek R, Rocheleau G, Rung J, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature. 2007;445(7130):881-885.

10. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995;10(1):111-113.

11. Fishman D, Faulds G, Jeffery R, et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest. 1998;102(7):1369-1376.

12. Uysal KT, Wiesbrock SM, Hotamisligil GS. Functional analysis of tumor necrosis factor (TNF) receptors in TNF-induced insulin resistance in genetic obesity. J Clin Invest. 1998;102(2):402-410.

13. Ridker PM, Buring JE, Cook NR, Rifai N. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14,719 initially healthy American women. Circulation. 2003;107(3):391-397.

14. American Diabetes Association. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2024. Diabetes Care. 2024;47(Supplement_1):S19-S38. doi:10.2337/dc24-S002

The Detox Mandate: Reset, Rewire, and Outpace Today’s Toxins

Mon, 08 Sep 2025 17:58:42 GMT

The Detox Mandate: Reset, Rewire, and Outpace Today’s Toxins

“In a toxic world, detox is not indulgence — it is intelligent self-preservation.”

1. Modern Toxic Burden Demands Modern Solutions

We no longer live in the clean, agrarian world our ancestors knew. Today, we are immersed in a chemical cocktail from the moment we wake: microplastics—up to 10,000 particles per liter—pervade our drinking water; 70% of produce carries pesticide residues, often multiple types; heavy metals contaminate millions of hectares of farmland; over 90% of us have endocrine disruptors like BPA in our bodies from cosmetics and receipts; and nearly 60% of our calories come from ultra-processed, inflammation-promoting foods.

Plastics leach micro-particles into our water
Pesticides lingering on produce
Heavy metals seeping through the soil
Endocrine disruptors hiding in cosmetics and receipts
Inflammatory ultra-processed foods disguised as “convenience”

This constant, low-grade exposure silently taxes the body’s detox machinery: the liver, kidneys, gut, skin, and lungs. These organs are remarkable, but not invincible.

Over time, unprocessed toxins create a hidden undercurrent of inflammation. Inflammation is the soil where chronic disease takes root: premature aging, weight gain, fatigue, hormonal chaos, cardiovascular disease, autoimmune conditions, and even neurodegeneration.

A structured, twice-yearly cleanse is not about chasing trends. It is about resetting resilience, giving the body space to unburden, recalibrate, and restore balance in a world that no longer plays fair. As we consider our internal defenses, it's essential to understand how our bodies are designed to cope with these challenges.

2. Your Body Has Detox Systems — But They Can Be Overloaded

The human body is brilliantly designed with built-in cleansing machinery:

Liver & enzymes : Break toxins into safer byproducts through Phase I and Phase II pathways.
Gut & microbiome : Package waste, bind toxins, and prevent them from being reabsorbed.
Kidneys & lymph : Filter blood, drain cellular debris, and maintain fluid balance.
Skin & lungs : Release compounds through sweat and breath.

Yet even these systems, elegant and efficient as they are, buckle under modern conditions. Some might argue that the liver already detoxifies naturally, which is true to an extent. However, the unprecedented levels of environmental toxins today mean that our natural detox pathways can become overwhelmed. When detox pathways become sluggish or overburdened, the body starts recycling what it cannot eliminate. This makes structured cleansing an essential complement to our internal systems, helping to support and enhance what they naturally do.

The result? Fatigue, brain fog, stubborn weight, hormone misfires, and the silent inflammation that fuels chronic disease.

Cleansing is not about replacing your body’s intelligence; it is about supporting and unblocking it so these pathways can perform at full capacity. Now, let’s explore how modern approaches combine science and medicine to enhance the process.

3. Backed by Science, Elevated by Functional Medicine

A proper cleanse is not starvation or deprivation. It is targeted nourishment, designed to support the body’s detoxification pathways on a cellular level.

Liver Support
The liver is your chemical factory and filtration plant in one. Nutrients such as milk thistle (silymarin), N-acetylcysteine (NAC) , and glutathione precursors upregulate Phase I and Phase II detoxification—the two essential steps in neutralizing toxins and making them water-soluble for elimination.

Clinical studies have shown that NAC replenishes glutathione, thereby reducing oxidative stress and improving liver enzyme balance.

Gut Reset
A clogged gut equals recirculated toxins. Fiber blends, psyllium husk, slippery elm, and prebiotic inulin bind waste products and carry them out, while also feeding beneficial bacteria. This double action clears toxic load and rebalances the microbiome, improving digestion, reducing bloating, and calming gut-immune cross-talk.

Cellular Renewal
Cleansing is not just about elimination; it is also about protection. Imagine plant antioxidants as a "rust-proof coating" for your cells, shielding them from damage. Compounds from acai, chlorella, chlorophyll, and green tea catechins reduce oxidative stress, shield mitochondria, and protect DNA from damage caused by free radicals. Research confirms that antioxidant-rich protocols improve markers of cellular resilience and slow the biological aging process.

This is what separates a functional medicine cleanse from a fad diet: it does not strip the body down; it fortifies it. Upon closer examination, we discover that genetic individuality plays a significant role in determining detoxification needs.

4. The Genomic Advantage: Cleansing to Your Code

“Your DNA is not your destiny. But it does explain why you may need the reset more than someone else.”

Your DNA is your blueprint for detox efficiency. And like all blueprints, some have shortcuts, while others have missing sections.

Gene Spotlight: Detox Pathways

GST Genes (Glutathione Transferases) : Critical for producing glutathione, your master detox molecule. Variants or deletions (like GSTM1 null) mean your body makes less, leaving you vulnerable to oxidative stress.
MTHFR: Governs methylation, essential for Phase II detox. Mutations slow the clearance of homocysteine and disrupt the processing of toxins.
CYP450 Enzymes : Control Phase I metabolism of drugs, caffeine, and chemicals. Variations (like CYP1A2) can make you a "slow metabolizer," turning everyday exposures into prolonged burdens. For example, individuals with slow CYP1A2 metabolism may find that limiting caffeine intake to 100 mg per day helps manage prolonged stimulant effects. Integrating such personalized adjustments demonstrates how genomic knowledge translates into daily choices.
NAT2 : Determines whether you are a fast or slow acetylator, impacting your ability to process carcinogens from smoke, charred meats, and pollutants.
PON1 & GPX1 : Influence how your body clears pesticides and neutralizes oxidative damage.

For those with less efficient variants, toxin accumulation is inevitable unless supported. Functional medicine utilizes nutrigenomics to overcome genetic roadblocks and enhance detoxification efficiency .

A twice-yearly cleanse is, in essence, giving your genes a biological advantage in a toxic world. As these rhythms align with functional medicine, let's explore how cleansing fits into your annual wellness routine.

5. Functional Medicine Consensus: Reset with Rhythm

Functional medicine views cleansing not as a fad, but as a form of seasonal intelligence.

New Year Reset : After the indulgences of the holidays, January becomes a symbolic and physiological clean slate. A cleanse here helps restore balance, sharpen mental clarity, and set a tone of vitality for the months ahead.
Post-Summer Cleanse (Fall): After months of travel, sun exposure, indulgence, and social rhythms, the body craves recalibration. This cleanse clears accumulated stressors before the slower, heavier foods and lifestyle of winter take hold.
Optional Spring Tune-Up : For individuals with higher toxin exposures, chronic stress, or genetic vulnerabilities, a gentle spring cleanse can provide additional resilience and help maintain momentum.

These resets:
✔ Clear metabolic waste
✔ Rebalance hormones
✔ Restore gut-immune balance
✔ Improve metabolic flexibility

6. Why Twice a Year Matters

Food alone, however clean, cannot always meet today’s detox demands. Nutrient density in modern soils has declined; environmental exposures have risen exponentially.

Twice-yearly cleansing ensures:

Therapeutic concentrations of botanicals, antioxidants, and phytonutrients — in ways diet alone may not provide.
Genomic vulnerabilities are supported before they manifest as symptoms.
Preventive rhythms become embedded in your lifestyle — just like scheduling dental cleanings or annual physicals.

This approach is not about restrictions. It is a precise, proactive way to support your biology with the reset it needs to function optimally. To summarize, the most effective approach incorporates both scientific insight and practical rhythm.

The Takeaway

In a toxic world, detox is not optional. It is the intelligent rhythm of modern living. Twice yearly, at the beginning of the year and again in the fall, gives your body structured breathing room. For some, an optional spring cleanse adds resilience.

This is not wellness theater. This is functional medicine in motion — science, genomics, and seasonality woven together to protect your healthspan, enhance your clarity, and restore balance.

Order a copy today!

Read the code. Live the design. The rest follows.

Dr. Marios Michael

drmichaelswellness.com

Selected References

Thyroid and PSA: The Crosstalk

1. Thyroid Status Influences PSA Levels

a. Hyperthyroidism Increases PSA:

Shiraishi K, et al. “Serum prostate-specific antigen levels in patients with thyroid dysfunction.” Endocr J. 2003;50(6):821-6.
( Link )
Bahmad HF, et al. “Effect of hyperthyroidism on serum prostate-specific antigen concentrations in men.” Clin Chim Acta. 2017;470:1-4.
( Link )

b. Hypothyroidism Decreases PSA:

Shiraishi K, et al. (same as above)
D’Ambrosio V, et al. "Low serum prostate-specific antigen in patients with hypothyroidism is reversed after thyroid hormone replacement." J Endocrinol Invest. 2005;28(7):654-7.
( Link )

c. Mechanisms:

Benvenga S, et al. “Thyroid hormones and prostate: an intriguing relationship with clinical implications.” Endocrine. 2017;56(2):340-344.
( Link )

2. Functional Medicine Perspectives & Hormone Interplay

a. Thyroid Hormones, Androgens, SHBG:

Gyllenborg J, et al. “Thyroid function and SHBG levels in healthy men.” J Intern Med. 2001;249(2):161-6.
( Link )

Benvenga S, et al. (same as above)

b. Reverse T3, Antibodies, and Cortisol:

Peeters RP, et al. “The metabolism of thyroid hormone: pathways of hormone metabolism and the role of deiodinases.” Endocr Rev. 2006;27(2): 124-192.
( Link )

Chrousos GP. “Stress and disorders of the stress system.” Nat Rev Endocrinol. 2009;5(7):374-81.
( Link )

3. Nutrition & PSA/Thyroid Modulation

a. Mediterranean Diet, Crucifers, Polyphenols, Omega-3:

Schwingshackl L, et al. “Adherence to Mediterranean diet and risk of cancer: an updated systematic review and meta-analysis.” Nutrients. 2017;9(10):1063.
( Link )

Richman EL, et al. “Intakes of meat, fish, poultry, and eggs and risk of prostate cancer progression.” Am J Clin Nutr. 2010;91(3):712-21.
( Link )

Pantuck AJ, et al. “Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer.” Clin Cancer Res. 2006;12(13):4018-26.
( Link )

Henning SM, et al. “Green tea and prostate cancer: From bench to clinic.” Front Nutr. 2017;4:3.
( Link )

Peluso I, et al. “Polyphenols and prostate cancer: molecular mechanisms and clinical evidence.” Nutrients. 2018;10(6):698.
( Link )

b. Omega-3s and Prostate/Thyroid Health:

Li D, et al. “Omega-3 fatty acids in prostate cancer: a meta-analysis.” Nutrients. 2015;7(7):5552-71.
( Link )

Ma J, et al. “Dietary n-3 and n-6 fatty acids and risk of prostate cancer: meta-analysis of prospective studies.” BMJ. 2010;341:c3535.
( Link )

Cholewska P, et al. “Nutritional factors and thyroid autoimmunity.” Nutrients. 2021;13(11):4114.
( Link )

c. Dairy, Red Meat, IGF-1:

Rowlands MA, et al. “Intakes of dairy products and calcium and prostate cancer risk.” Am J Clin Nutr. 2007;86(3):929-37.
( Link )

Allen NE, et al. “Prostate cancer risk and serum insulin-like growth factor (IGF)-I, IGF-II, IGF-binding protein-3, and transforming growth factor-β1.” Br J Cancer. 2000;83(11):1347-53.
( Link )

4. Supplements

a. Vitamin D, Zinc, Selenium:

Travis RC, et al. “Serum vitamin D and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition (EPIC).” Am J Clin Nutr. 2009;89(5): 1394-401.
( Link )

Costello LC, Franklin RB. “Zinc is decreased in prostate cancer: an established relationship of prostate cancer.” J Biol Inorg Chem. 2011;16(1):3-8.
( Link )

Vinceti M, et al. “Selenium for preventing cancer.” Cochrane Database Syst Rev. 2018;1(1):CD005195.
( Link )

b. Curcumin, Saw Palmetto, Pygeum:

Kunnumakkara AB, et al. “Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases.” Br J Pharmacol. 2017;174(11):1325-1348.
( Link )

Kaplan SA, et al. “Saw palmetto in lower urinary tract symptoms.” J Urol. 2004;171(6 Pt 1):2321-5.
( Link )

Wilt TJ, et al. “Pygeum africanum for benign prostatic hyperplasia.” Cochrane Database Syst Rev. 2002;(1):CD001044.
( Link )

Lopresti AL, et al. “Adaptogenic and anxiolytic effects of ashwagandha root extract.” Medicine (Baltimore). 2019;98(37):e17186.
( Link )

5. Lifestyle: Exercise, Weight, Stress, Sleep

Hara N, et al. “Effect of exercise on serum prostate-specific antigen levels in men with prostate cancer.” Prostate. 2004;59(4):372-7.
( Link )

Haqq L, et al. “The impact of weight loss on prostate-specific antigen: a systematic review.” Prostate Cancer Prostatic Dis. 2017;20(1):1-8.
( Link )

Irwin MR, et al. “Sleep loss activates cellular markers of inflammation: sex differences.” Brain Behav Immun. 2010;24(1):54-7.
( Link )

Chrousos GP. “Stress and disorders of the stress system.” (same as above)

6. Botanical and Herbal Allies

Safarinejad MR. “Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study.” J Herb Pharmacother. 2005;5(4):1-11.
( Link )

Henning SM, et al. “Green tea and prostate cancer: From bench to clinic.” (same as above)
Singh CK, et al. “Resveratrol, in cancer prevention and therapy.” Ann N Y Acad Sci. 2011;1215:1-8.
( Link )

Giovannucci E, et al. “Intake of carotenoids and retinol in relation to risk of prostate cancer.” J Natl Cancer Inst. 1995;87(23):1767-76.
( Link )

7. Genomics & Personalized Medicine

Friso S, et al. “A common variant in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation.” J Biol Chem. 2002;277(5):35733-6.
( Link )

Lyssenko V, et al. “Genetic variation in the TCF7L2 gene is associated with increased risk of type 2 diabetes and impaired proinsulin conversion.” Nat Genet. 2007;39(2):218-25.
( Link )

Soerensen M, et al. “Genetic variation in FOXO3 is associated with variation in human longevity.” Aging Cell. 2010;9(4):543-52.
( Link )

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

References: Supporting Evidence

1. Klaassen CD, Watkins JB. Mechanisms of hepatobiliary excretion and detoxification. Pharmacol Rev. 1984. PubMed 6374107

- Supports: The burden of plastics, heavy metals, detox organ function, and the impact of modern toxins on the liver and kidneys.

2. Martinsen TC, et al. The role of the gut barrier and microbiome in detoxification. Curr Opin Pharmacol. 2020. PubMed 32470667

- Supports: The role of the gut and microbiome in detoxification, the impact of microplastics, fiber, and prebiotics, and recirculation of toxins.

3. Costa LG, et al. Paraoxonase (PON1) polymorphisms and detoxification of organophosphates. J Biochem Mol Toxicol. 2020. PubMed 32027241

- Supports: Pesticide burden, genetic vulnerability (PON1, GPX1), and the body’s ability to clear pesticides.

4. Lampe JW. Diet, genetic polymorphisms, and detoxification enzymes. Nutr Rev. 2007;65(5 Pt 2):S140-6. PubMed 17405687

- Supports: Endocrine disruptors, processed food impact, inflammation and disease risk, GST, MTHFR, and CYP gene roles in detox, and individual variability.

5. Aronica L, et al. Genetic Biomarkers of Metabolic Detoxification for Personalized Lifestyle Medicine (LIFEHOUSE study). Front Genet. 2022. PMC8876337

- Supports: Modern toxic burden, overwhelmed detox systems, inflammation, chronic disease risk, rationale for structured cleansing.

6. Chanhom N, et al. NAT2 genetic polymorphisms and acetylation status: implications for detox capacity. Pharmacogenomics J. 2021. PMC8082558

- Supports: NAT2 acetylator status, carcinogen processing from smoke and meat.

7. Ghezzi P. Glutathione: overview of its protective roles, measurement, and biosynthesis. Oxid Med Cell Longev. 2011. PMC3134519

- Supports: Glutathione and oxidative stress, NAC supplementation, the biological effect of antioxidants, GST function, and cellular resilience.

8. Mason SA, Welch VG, Neratko J. Synthetic Polymer Contamination in Bottled Water. Front Chem. 2018;6:407. doi:10.3389/fchem.2018.00407

- Supports: Microplastic levels in bottled water.

9. World Wildlife Fund (WWF). No Plastic in Nature: Assessing Plastic Ingestion from Nature to People. Dalberg, 2019.

- Supports: Estimated weekly microplastic ingestion in humans.

10. United States Department of Agriculture (USDA). Pesticide Data Program Annual Summary, Calendar Year 2022.

- Supports: Pesticide residues on produce.

11. Food and Agriculture Organization of the United Nations (FAO). Soil Pollution: A Hidden Reality. Rome: FAO, 2021.

- Supports: Heavy metal contamination of soils.

12. Centers for Disease Control and Prevention (CDC). Fourth National Report on Human Exposure to Environmental Chemicals. Updated 2019.

- Supports: BPA and endocrine disruptor exposure in Americans.

13. Martinez Steele E, et al. Ultra-processed foods and added sugars in the US diet: evidence from a nationally representative cross-sectional study. BMJ Open. 2016;6:e009892. doi:10.1136/bmjopen-2015-009892

- Supports: Percentage of calories from ultra-processed foods in the US diet.

Thyroid and PSA: The Hidden Crosstalk Men Shouldn’t Ignore

Thu, 04 Sep 2025 17:25:13 GMT

When Your Hair Speaks: What Female Hair Loss Really Tells Us

We often think of the prostate as a lone actor, measured by one number, PSA (prostate-specific antigen), and judged for enlargement or cancer risk. But biology doesn’t work in silos. The thyroid, a butterfly-shaped gland located in your neck, subtly influences how your prostate functions and how your PSA level is interpreted.

Understanding this connection can mean the difference between unnecessary worry and informed clarity.

Why This Connection Matters

PSA is one of the most common markers doctors use to screen for prostate health. But it isn’t always straightforward. Thyroid imbalances, whether overactive or underactive, can influence PSA levels and create confusion.

In functional medicine, the question isn’t just what is happening, but why. Here, the “why” involves hormones, metabolism, and inflammation that link two glands you might not expect to see in the same conversation.

What the Science Says

Research shows thyroid status significantly affects PSA levels — sometimes inflating them, sometimes suppressing them, regardless of prostate cancer.

Science Spotlight: Thyroid Status and PSA

1. Hyperthyroidism (Overactive Thyroid)

Mechanism: Excess thyroid hormone (T3/T4) increases metabolic activity and may stimulate androgen pathways, which can enhance prostate cell activity.

Effect on PSA: Studies show men with hyperthyroidism often have elevated PSA levels , even without prostate cancer. This is thought to be due to increased prostate blood flow, gland stimulation, and possibly increased androgen receptor sensitivity.

2. Hypothyroidism (Underactive Thyroid)

Mechanism: Low thyroid hormone tends to slow metabolism, lower testosterone levels, and reduce prostate stimulation.

Effect on PSA: Hypothyroid men often show reduced PSA levels compared to euthyroid men. In some cases, PSA can rise again after thyroid hormone replacement.

This dual pattern explains why PSA cannot be interpreted in isolation. Thyroid status can raise or lower PSA — independent of malignancy.

Functional Medicine Perspective: Looking Beyond TSH

In functional medicine, thyroid health is not a binary concept. It’s about how efficiently you produce, convert, and use thyroid hormones. Reverse T3, antibodies, and adrenal stress can all disrupt thyroid signaling and PSA levels.

Key Markers to Evaluate (Beyond Conventional Labs)

TSH (Thyroid-Stimulating Hormone): First signal of thyroid stress, but misleading if looked at alone.
Free T4 (Thyroxine): The storage hormone. Adequate T4 doesn’t guarantee it’s converting downstream.
Free T3 (Triiodothyronine): The active hormone at the cellular level. Low free T3 levels indicate poor signaling, sometimes accompanied by normal T4 levels.
Reverse T3 (rT3): A metabolic “brake pedal.” Elevated in stress, chronic illness, or inflammation, rT3 can block T3 at the receptor, leading to functional hypothyroidism even if blood levels look “normal.”
Thyroid Antibodies (TPO, TgAb): Hashimoto’s autoimmunity alters long-term thyroid signaling and indirectly impacts PSA by affecting androgen balance and systemic inflammation.
Sex Hormone–Binding Globulin (SHBG): Often elevated in hyperthyroid states, it lowers free testosterone and reshapes how the prostate responds.
Cortisol & DHEA (Adrenal Crosstalk): Chronic stress raises rT3, lowers free T3, and indirectly suppresses androgen-driven prostate signaling.

Nutrition: Food as Endocrine Modulators

Mediterranean Pattern: Olive oil, vegetables, legumes, fish. Reduces systemic inflammation (IL-6, CRP), stabilizes insulin, and balances thyroid–prostate signaling.
Cruciferous Vegetables: Broccoli, kale, Brussels sprouts. Sulforaphane and indole-3-carbinol support estrogen metabolism and downregulate signals that promote prostate overgrowth.
Pomegranate & Green Tea: Rich in polyphenols that suppress NF-κB and IGF-1 pathways, both linked to prostate inflammation and higher PSA.
Omega-3 Fatty Acids: Improve cell membrane signaling, lower thyroid autoimmunity, and reduce prostate inflammation.
Avoid Excessive Dairy & Red Meat: High intake is associated with elevated IGF-1 and higher PSA levels in some men.

Supplements: Precision Tools

Vitamin D3 + K2: Supports immune regulation and has been shown to slow PSA rise in some men on surveillance.
Zinc: Essential for thyroid hormone production and prostate integrity. Deficiency is linked with higher PSA and worse pathology.
Selenium: Facilitates thyroid conversion (T4 → T3) and reduces oxidative stress in the prostate.
Curcumin (Turmeric Extract): Potent NF-κB inhibitor. Studies have shown that it reduces prostate cell proliferation and inflammation.
SSaw Palmetto + Pygeum: Reduce DHT activity, improve urinary flow, and often lower PSA in men with BPH. Ashwagandha & Adaptogens: Lower cortisol-driven rT3, improve thyroid balance, and stabilize PSA.

Lifestyle & Movement: Turning Down the Heat

Exercise: 150+ minutes per week lowers PSA variability by reducing inflammation, balancing insulin, and optimizing testosterone metabolism.
Weight Optimization: Central obesity drives insulin resistance and IGF-1, which stimulates PSA. Losing weight normalizes thyroid hormones and lowers PSA levels.
Stress Reduction (Meditation, Breathwork, Prayer): Chronic stress raises rT3 and disrupts cortisol, destabilizing PSA.
Sleep: Deep, restorative sleep helps raise melatonin, which in turn protects thyroid function and reduces the risk of prostate cancer.

Herbal & Botanical Allies

Nettle Root: Reduces SHBG binding, moderates free testosterone activity, and helps lower PSA stimulation.
Green Tea Extract (EGCG): Shown to slow PSA rise in men with prostate cancer and modulate thyroid autoimmunity.
Resveratrol influences androgen receptor expression and lowers inflammatory markers associated with PSA elevation.
Lycopene (Tomatoes, Watermelon): Antioxidant with specific data for prostate health; higher intake correlates with lower PSA.

Genomics Meets Lifestyle

Certain genetic variants influence how nutrition, stress, and hormones play out in the thyroid–prostate axis:

MTHFR (methylation): Poor methylators benefit from methylated B vitamins to optimize thyroid conversion and reduce inflammatory PSA drivers.
TCF7L2 (insulin resistance): Maintaining blood sugar balance via Mediterranean eating is non-negotiable for prostate and thyroid health.
FOXO3 (longevity): Modulates stress resistance; lifestyle practices, such as fasting and exercise, upregulate FOXO3, thereby reducing PSA-promoting inflammation.

Integration Point: Genetics + thyroid function + lifestyle = personalized prostate strategy.

Putting It All Together

Hyperthyroid → PSA goes up.
Hypothyroid → PSA goes down.
Normalizing thyroid function → normalizes PSA.
Nutrition, supplements, herbs, exercise, stress mastery, and sleep → tools to keep both thyroid and prostate balanced.

PSA doesn’t just measure the prostate. It reflects the orchestra of thyroid hormones, metabolism, and lifestyle signals that shape a man’s biology.

Order a copy today!

Read the code. Live the design. The rest follows.

Dr. Marios Michael

drmichaelswellness.com

Selected References

Thyroid and PSA: The Crosstalk

1. Thyroid Status Influences PSA Levels

a. Hyperthyroidism Increases PSA:

Shiraishi K, et al. “Serum prostate-specific antigen levels in patients with thyroid dysfunction.” Endocr J. 2003;50(6):821-6.
( Link )
Bahmad HF, et al. “Effect of hyperthyroidism on serum prostate-specific antigen concentrations in men.” Clin Chim Acta. 2017;470:1-4.
( Link )

b. Hypothyroidism Decreases PSA:

Shiraishi K, et al. (same as above)
D’Ambrosio V, et al. "Low serum prostate-specific antigen in patients with hypothyroidism is reversed after thyroid hormone replacement." J Endocrinol Invest. 2005;28(7):654-7.
( Link )

c. Mechanisms:

Benvenga S, et al. “Thyroid hormones and prostate: an intriguing relationship with clinical implications.” Endocrine. 2017;56(2):340-344.
( Link )

2. Functional Medicine Perspectives & Hormone Interplay

a. Thyroid Hormones, Androgens, SHBG:

Gyllenborg J, et al. “Thyroid function and SHBG levels in healthy men.” J Intern Med. 2001;249(2):161-6.
( Link )

Benvenga S, et al. (same as above)

b. Reverse T3, Antibodies, and Cortisol:

Peeters RP, et al. “The metabolism of thyroid hormone: pathways of hormone metabolism and the role of deiodinases.” Endocr Rev. 2006;27(2): 124-192.
( Link )

Chrousos GP. “Stress and disorders of the stress system.” Nat Rev Endocrinol. 2009;5(7):374-81.
( Link )

3. Nutrition & PSA/Thyroid Modulation

a. Mediterranean Diet, Crucifers, Polyphenols, Omega-3:

Schwingshackl L, et al. “Adherence to Mediterranean diet and risk of cancer: an updated systematic review and meta-analysis.” Nutrients. 2017;9(10):1063.
( Link )

Richman EL, et al. “Intakes of meat, fish, poultry, and eggs and risk of prostate cancer progression.” Am J Clin Nutr. 2010;91(3):712-21.
( Link )

Pantuck AJ, et al. “Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer.” Clin Cancer Res. 2006;12(13):4018-26.
( Link )

Henning SM, et al. “Green tea and prostate cancer: From bench to clinic.” Front Nutr. 2017;4:3.
( Link )

Peluso I, et al. “Polyphenols and prostate cancer: molecular mechanisms and clinical evidence.” Nutrients. 2018;10(6):698.
( Link )

b. Omega-3s and Prostate/Thyroid Health:

Li D, et al. “Omega-3 fatty acids in prostate cancer: a meta-analysis.” Nutrients. 2015;7(7):5552-71.
( Link )

Ma J, et al. “Dietary n-3 and n-6 fatty acids and risk of prostate cancer: meta-analysis of prospective studies.” BMJ. 2010;341:c3535.
( Link )

Cholewska P, et al. “Nutritional factors and thyroid autoimmunity.” Nutrients. 2021;13(11):4114.
( Link )

c. Dairy, Red Meat, IGF-1:

Rowlands MA, et al. “Intakes of dairy products and calcium and prostate cancer risk.” Am J Clin Nutr. 2007;86(3):929-37.
( Link )

Allen NE, et al. “Prostate cancer risk and serum insulin-like growth factor (IGF)-I, IGF-II, IGF-binding protein-3, and transforming growth factor-β1.” Br J Cancer. 2000;83(11):1347-53.
( Link )

4. Supplements

a. Vitamin D, Zinc, Selenium:

Travis RC, et al. “Serum vitamin D and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition (EPIC).” Am J Clin Nutr. 2009;89(5): 1394-401.
( Link )

Costello LC, Franklin RB. “Zinc is decreased in prostate cancer: an established relationship of prostate cancer.” J Biol Inorg Chem. 2011;16(1):3-8.
( Link )

Vinceti M, et al. “Selenium for preventing cancer.” Cochrane Database Syst Rev. 2018;1(1):CD005195.
( Link )

b. Curcumin, Saw Palmetto, Pygeum:

Kunnumakkara AB, et al. “Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases.” Br J Pharmacol. 2017;174(11):1325-1348.
( Link )

Kaplan SA, et al. “Saw palmetto in lower urinary tract symptoms.” J Urol. 2004;171(6 Pt 1):2321-5.
( Link )

Wilt TJ, et al. “Pygeum africanum for benign prostatic hyperplasia.” Cochrane Database Syst Rev. 2002;(1):CD001044.
( Link )

Lopresti AL, et al. “Adaptogenic and anxiolytic effects of ashwagandha root extract.” Medicine (Baltimore). 2019;98(37):e17186.
( Link )

5. Lifestyle: Exercise, Weight, Stress, Sleep

Hara N, et al. “Effect of exercise on serum prostate-specific antigen levels in men with prostate cancer.” Prostate. 2004;59(4):372-7.
( Link )

Haqq L, et al. “The impact of weight loss on prostate-specific antigen: a systematic review.” Prostate Cancer Prostatic Dis. 2017;20(1):1-8.
( Link )

Irwin MR, et al. “Sleep loss activates cellular markers of inflammation: sex differences.” Brain Behav Immun. 2010;24(1):54-7.
( Link )

Chrousos GP. “Stress and disorders of the stress system.” (same as above)

6. Botanical and Herbal Allies

Safarinejad MR. “Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study.” J Herb Pharmacother. 2005;5(4):1-11.
( Link )

Henning SM, et al. “Green tea and prostate cancer: From bench to clinic.” (same as above)
Singh CK, et al. “Resveratrol, in cancer prevention and therapy.” Ann N Y Acad Sci. 2011;1215:1-8.
( Link )

Giovannucci E, et al. “Intake of carotenoids and retinol in relation to risk of prostate cancer.” J Natl Cancer Inst. 1995;87(23):1767-76.
( Link )

7. Genomics & Personalized Medicine

Friso S, et al. “A common variant in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation.” J Biol Chem. 2002;277(5):35733-6.
( Link )

Lyssenko V, et al. “Genetic variation in the TCF7L2 gene is associated with increased risk of type 2 diabetes and impaired proinsulin conversion.” Nat Genet. 2007;39(2):218-25.
( Link )

Soerensen M, et al. “Genetic variation in FOXO3 is associated with variation in human longevity.” Aging Cell. 2010;9(4):543-52.
( Link )

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

When Your Hair Speaks: What Female Hair Loss Really Tells Us

Wed, 03 Sep 2025 13:49:39 GMT

When Your Hair Speaks: What Female Hair Loss Really Tells Us

Discover the causes of female hair thinning and how hormones, nutrients, toxins, mold exposure, stress, and liver health impact your hair. Learn how functional medicine restores balance from the inside out.

Hair as a Messenger, Not a Vanity Issue

Hair. We often see it as cosmetic, a crown, a style, a confidence marker. But in functional medicine, hair is something more: a messenger. When it sheds, thins, or loses its shine, it's not just vanity talking. It's your biology whispering that something deeper is out of tune. Imagine a new mother experiencing hair loss a few months postpartum—it's not just the stress of sleepless nights; her body is adjusting hormone levels back to normal after pregnancy. This is a vivid example of how hair can reflect inner changes.

“Your scalp is not the problem. It’s the stage. The actors are your hormones, nutrients, stress levels, circulation, immunity, toxins, and even your gut.”

The Systems Behind the Strands

Endocrine Symphony: Hormones in Balance

Low thyroid leads to weak, brittle hair, while high thyroid causes diffuse shedding. In fact, approximately 30% of women with hypothyroidism experience significant hair changes, highlighting the crucial role hormones play in hair health.
Ovaries & Adrenals: Estrogen and progesterone regulate hair growth. When they dip (menopause, postpartum), shedding accelerates. Testosterone converting to DHT shrinks follicles.
Pituitary: The conductor of the orchestra, with prolactin and other hormones influencing growth.

Nutrient & Metabolic Foundation

Hair is built from protein — but it also relies on iron, vitamin D, zinc, and B12. If the gut isn’t absorbing well, or if the liver can’t process nutrients and hormones, the follicles struggle.

Immune System & Inflammation

Sometimes, the immune system mistakenly identifies follicles as invaders. In alopecia areata, it launches a direct attack. Even without autoimmunity, chronic inflammation suffocates growth and miniaturizes follicles.

Stress Circuitry: The Cortisol Connection

Stress is not just “in your head.” Elevated cortisol prompts hair to enter the resting (telogen) phase, leading to shedding weeks later.

Circulatory Pathways: Nourishing the Follicle

Hair follicles are among the most metabolically active tissues in the body. They rely on rich microcirculation for the delivery of oxygen and nutrients. Without it, growth falters.

The Hidden Culprits: Toxins, Mold, and Liver Health

When the Body Is Overloaded

Pesticides, plastics, heavy metals, and mold toxins don’t just strain your body; they disrupt hormone balance, inflame tissues, and overwhelm detoxification pathways, leaving hair health as collateral damage. For instance, cadmium, a heavy metal commonly found in the environment, can interfere with zinc uptake—a mineral crucial for hair and overall health—illustrating how toxins interfere with the body's ability to maintain balance.

The Liver: Silent Guardian of Your Strands

Your liver is more than an alcohol filter. It’s a biochemical hub that:

Processes hormones (estrogen, testosterone, cortisol).
Neutralizes toxins and mold byproducts.
Packages nutrients like iron and amino acids for delivery.

When the liver slows down or becomes overloaded, hormones back up, toxins linger, and follicles suffer the consequences. Everyday habits can contribute to this overload. For instance, regular use of acetaminophen or enjoying a glass of wine each night can silently strain the liver, affecting its ability to detoxify effectively. By recognizing these common triggers, you can take proactive steps to support your liver and improve your hair health.

Mold & Hair Loss

Mycotoxins from mold exposure — often in water-damaged buildings — can:

Disrupt thyroid and adrenal function.
Elevate inflammation and oxidative stress.
Trigger autoimmune tendencies that attack follicles.

For many women, the combination of fatigue, brain fog, and hair loss is the first clue that mold exposure is at play.

Sidebar: Signs Your Hair Loss May Be Linked to Toxins or Mold

You’ve lived or worked in a water-damaged building (musty smell, visible mold).
You struggle with unexplained fatigue, brain fog, or chronic sinus issues.
Your hair loss began after a move, renovation, or water leak.
You experience multiple sensitivities, including those to perfumes, cleaning products, and certain foods.
You experience digestive upset despite eating a well-balanced diet.
Your labs show abnormal liver enzymes or low levels of detoxification nutrients (such as glutathione and B vitamins).

If these resonate, it may be time to explore mycotoxin testing, liver support, and detox strategies with a functional medicine practitioner. To start your journey toward better health, consider scheduling a root-cause assessment this month. This step can help you pinpoint underlying issues and begin addressing them promptly.

The Functional Medicine Process

Investigate
Comprehensive labs: thyroid, hormones, iron, vitamins, inflammation, gut health, liver enzymes, toxins, and mold panels.
Correct
Replete nutrient deficiencies, balance hormones, calm inflammation, and restore detox capacity.
Support
Prioritize sleep, manage stress, optimize circulation, and incorporate liver-loving foods (such as crucifers, bitters, and antioxidants).
Strengthen
Utilize targeted therapies — ranging from botanicals (such as saw palmetto, spearmint, and reishi) to advanced approaches like PRP and microneedling.

Beyond the Scalp: A Smarter Takeaway

Your hair is more than cosmetic. It’s a diagnostic signal of whole-body health. Addressing female hair loss through a functional medicine lens doesn’t just restore strands — it restores energy, balance, and resilience.

✨ Bottom line: Hair doesn’t lie. It reflects your hormones, nutrients, stress levels, detoxification capacity, and immunity. Decode the signal, and you elevate more than your hair — you elevate your health.

Your health isn’t random. It’s written in code. And the art isn’t in adding louder advice, but in learning to listen to the whispers already inside you. That’s the journey I share in Understanding Genomics: How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers. Order a copy today!

Read the code. Live the design. The rest follows.

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Hudson, T. (2019). Women’s Hair Loss: The Hidden Epidemic. Integrative Medicine: A Clinician’s Journal, 18(3), 40–45.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691938/
Almohanna, H. M., Ahmed, A. A., Tsatalis, J. P., & Tosti, A. (2019). The Role of Vitamins and Minerals in Hair Loss: A Review. Dermatology and Therapy, 9(1), 51–70.
https://doi.org/10.1007/s13555-018-0278-6
Bregy, A., Trueb, R. M., & Trüeb, R. M. (2015). Female Pattern Hair Loss. Journal of the German Society of Dermatology, 13(1), 25–33.
https://doi.org/10.1111/ddg.12554
Hadshiew, I. M., Foitzik, K., Arck, P. C., & Paus, R. (2004). Stress and the Hair Follicle: Exploring the Connections. American Journal of Pathology, 165(4), 1219–1228.
https://doi.org/10.1016/S0002-9440(10)63384-9
Murphree, D. H. (2017). An Integrative Approach to Female Pattern Hair Loss. Alternative and Complementary Therapies, 23(6), 244–249.
https://doi.org/10.1089/act.2017.29140.dhm
Ho, J. D., Lin, F. J., Lin, C. L., & Sung, F. C. (2017). Increased Risk of Alopecia Areata in Patients With Atopic Dermatitis: A Population-Based Study. Journal of Dermatology, 44(8), 909–915.
https://doi.org/10.1111/1346-8138.13860
Genuis, S. J. (2011). Detoxification and Healing: The Role of the Liver in Health and Disease. Journal of Environmental and Public Health, 2011, Article ID 948740.
https://doi.org/10.1155/2011/948740
Shoemaker, R. C., House, D. E. (2006). Sick Building Syndrome (SBS) and Exposure to Water-Damaged Buildings: Mold, Mycotoxins, and Human Health. Neurotoxicology and Teratology, 28(5), 573–578.
https://doi.org/10.1016/j.ntt.2006.07.004
Trüeb, R. M. (2009). Oxidative Stress in Ageing of Hair. International Journal of Trichology, 1(1), 6–14.
https://doi.org/10.4103/0974-7753.51923
National Institutes of Health. (2022). Hair Loss in Women: MedlinePlus Medical Encyclopedia.
https://medlineplus.gov/ency/article/007205.htm

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

How to Get Rid of Cellulite with Functional Medicine: The Ultimate Guide

scott@skywax.com (Scott Lucas) — Wed, 05 Oct 2022 18:02:09 GMT

How to Get Rid of Cellulite with Functional Medicine: The Ultimate Guide

Cellulite is a perplexing issue for women of all ages, sizes, and ethnic backgrounds. With 80 percent of women over the age of 20 having cellulite, even if it's slight, you're in the vast majority. Even though cellulite is a common and mostly harmless condition, it can be tough to deal with emotionally and physically. If you're one of the many people who are unhappy with their appearance because of cellulite, don't despair. There are things you can do to improve your situation. Cellulite doesn't have to ruin your life. With a little effort, you can feel better about yourself.

What is Cellulite?

Cellulite is a common skin condition that causes dimpled, lumpy skin, usually on the thighs, buttocks, stomach, and arms. As Dr. Murry states in the Textbook of Natural Medicine, 5th edition (2020), "Cellulite, known as liposclerosis, is a noninflammatory change within the subcutaneous adipose tissue caused by an increase in the volume of fat cells or by the increased division of connective tissue, which causes constriction of small blood vessels". In other words, cellulite occurs when the fat cells in these areas expand and push through the collagen fibers, or connective tissue, that support them. This process causes the dimpling effect often seen on the surface of the skin.

Causes of Cellulite

Cellulite is not a disease or an indication of poor health, although it can be a sign of excess body fat. Cellulite can happen for several reasons, including enlarged fatty cells, inflammation, hormonal imbalances, skin genomics, muscle tone, weight issues, fat cell hormonal imbalances, poor diet, lack of exercise, and toxins in the body. Cellulite is more common in women than men because of the way fat is distributed in the body. Women also have thinner skin than men, which can make cellulite more visible.

Functional Medicine's Actionable Tips to Help Reduce Cellulite

Detox with Practitioner- Grade Supplements

The first step is to detox or cleanse to help reset your systems. Consider it a type of reboot for your system. There are many ways to do this, but I recommend starting with a Functional Medicine approach. This means working with a Practitioner to help you detoxify your body and get rid of any inflammation-causing foods or toxins. This can be done through diet, Practitioner -Grade supplements, and lifestyle changes.

There are two types of toxins: water-soluble and fat-soluble. Water-soluble toxins are easily flushed out of the body, but fat-soluble toxins require a little more effort to get rid of. Fat-soluble toxins, as the name implies, are found in our fat cells and can wreak havoc on our bodies' health systems. For our body to get rid of these toxins, they must first be converted into water-soluble toxins. Afterward, the lymphatic drainage system, various organs, and functionally related systems help flush these toxins out. A successful detox plan expels both fat- and water-soluble toxins, as well as facilitates the process of transformation from one to the other. One of the best ways is to detox with Practitioner-Grade supplements. As always consult with your physician before starting any detox plan.

Inflammation

Cellulite is often caused by inflammation, so one of the best things you can do is try to reduce inflammation in your body. Detoxing and cleansing with Practitioner-Grade supplements can help to reduce inflammation as well as help with weight loss and the appearance of cellulite.

Hormonal Imbalances

Hormonal imbalances can cause several issues in the body, including weight gain, inflammation, and cellulite. If you suspect you have a hormonal imbalance, it's important to see a practitioner who can test your hormone levels and help you develop a plan to get them back into balance. For lasting hormone balance, you may want to consider seeing a Functional Medicine Practitioner.

Circulation

Cellulite can also be improved with circulation supplements. Circulation is important for getting rid of cellulite because it helps with oxygenation and nutrient delivery to the area. It also helps to remove waste products and toxins from the area.

Diet

Choose a diet rich in alkaline foods from the Mediterranean diet. One way to do this is to alkalize the body. Alkalizing the body means eating more alkaline foods and less acidic foods.

Alkaline foods include fruits, vegetables, nuts, and seeds. Acidic foods include meat, dairy, processed foods, and sugar. Eating more alkaline foods and less acidic foods will help to reduce inflammation and detoxify the body. This will help to reduce the appearance of cellulite.

Exercise

Exercise is also important in helping to get rid of cellulite. Cellulite often occurs when there is a build-up of toxins in the body, so exercising and sweating can help to flush out these toxins. Exercise can also help this process by improving circulation and lymphatic drainage as well as your skin's appearance and elasticity. Finally, working out strengthens the muscle fibers and connective tissue which can help stave off the creation of cellulite.

Adiponectin and Leptin Imbalance

Two hormones, adiponectin, and leptin located within fat cells play a role in cellulite formation. Adiponectin helps regulates fat metabolism while leptin controls appetite. Cellulite often occurs when there is an imbalance of these two critical hormones.

Infrared Sauna, Massage, and Dry Brushing

In addition, there are other things you can do to help with cellulite. Infrared sauna, Massage, and Dry brushing are all great ways to improve circulation, stimulate your lymphatic drainage system, and break down the fat cells that cause cellulite.

Non-Invasive Non-Surgical Methods

Cavitation and Radiofrequency

Body Contouring techniques with Medical Grade equipment using Ultrasound Cavitation and Radiofrequency (RF) are excellent ways to help get rid of cellulite. Body Ultrasound cavitation employs sound waves to break down fat cells, while RF uses radio frequencies to heat the tissue and break down the fat cells as well as improve skin elasticity. Combining both of these techniques into a single treatment is even more effective in breaking down the fat cells that cause cellulite.

Acoustic Waves

Acoustic waves are also a great way to improve circulation and help break down the fat cells that cause cellulite. Acoustic waves stimulate the growth of new blood vessels and help to break down fat cells.

Vibration Plate

A Vibration Plate (VP) is also a great way to improve circulation and help break down the fat cells and reduce inflammation that causes cellulite. VP also helps with stimulating the lymphatic drainage system thus improving lymphatic circulation. It also improves muscle tension and myofibril connective tissue through reflex activation.

Other treatments

There are also many topical treatments that can help to reduce the appearance of cellulite. These include creams, gels, and wraps. Many of these products contain ingredients that help to break down fat cells and reduce inflammation.

While there is no one-size-fits-all solution to cellulite, these tips can help you get started on the road to improving your appearance and your health. Cellulite doesn't have to be a life sentence. With a little effort, you can start seeing results.

At our Practice, each patient's treatment is customized to meet their specific needs, and we've seen significant results when combined with a 10-day systems reset therapy program, simple workouts, Vibration Plate, and body contouring procedures combining Ultrasound Cavitation and Radiofrequency.

If you are looking for a more comprehensive Cellulite Treatment plan, book a free consultation with us today to see how we can help you achieve your goals!

Book a Free Consultation

If you'd like to learn more about Functional Medicine, Genomics, anti-aging techniques, increasing your health span, and how to utilize your DNA to your advantage, I highly recommend my new book, "Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers".

Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Dr. Marios Michael, DC, CNS, cFMP, 06/2022, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers, 1st edition, Austin, Bookbaby.

Tokarska K, Tokarski S, Woźniacka A, Sysa-Jędrzejowska A, Bogaczewicz J. Cellulite: a cosmetic or systemic issue? Contemporary views on the etiopathogenesis of cellulite. Postepy Dermatol Alergol. 2018 Oct;35(5):442-446. doi: 10.5114/ada.2018.77235. Epub 2018 Jul 19. PMID: 30429699; PMCID: PMC6232550.

Terranova F, Berardesca E, Maibach H. Cellulite: nature and aetiopathogenesis. Int J Cosmet Sci. 2006 Jun;28(3):157-67. doi: 10.1111/j.1467-2494.2006.00316.x. PMID: 18489272.

Sadick N. Treatment for cellulite. Int J Womens Dermatol. 2018 Oct 22;5(1):68-72. doi: 10.1016/j.ijwd.2018.09.002. PMID: 30809581; PMCID: PMC6374708.

V Leroy Young, MD, Barry E DiBernardo, MD, Comparison of Cellulite Severity Scales and Imaging Methods, Aesthetic Surgery Journal, Volume 41, Issue 6, June 2021, Pages NP521–NP537,

https://doi.org/10.1093/asj/sjaa226

Schunck M, Zague V, Oesser S, Proksch E. Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology. J Med Food. 2015 Dec;18(12):1340-8. doi: 10.1089/jmf.2015.0022. Epub 2015 Nov 12. PMID: 26561784; PMCID: PMC4685482.

Stern JH, Rutkowski JM, Scherer PE. Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk. Cell Metab. 2016 May 10;23(5):770-84. doi: 10.1016/j.cmet.2016.04.011. PMID: 27166942; PMCID: PMC4864949.

Frühbeck G, Catalán V, Rodríguez A, Gómez-Ambrosi J. Adiponectin-leptin ratio: A promising index to estimate adipose tissue dysfunction. Relation with obesity-associated cardiometabolic risk. Adipocyte. 2018 Jan 2;7(1):57-62. doi: 10.1080/21623945.2017.1402151. Epub 2017 Dec 5. PMID: 29205099; PMCID: PMC5915018.

Pilch W, Czerwińska-Ledwig O, Chitryniewicz-Rostek J, Nastałek M, Krężałek P, Jędrychowska D, Totko-Borkusewicz N, Uher I, Kaško D, Tota Ł, Tyka A, Tyka A, Piotrowska A. The Impact of Vibration Therapy Interventions on Skin Condition and Skin Temperature Changes in Young Women with Lipodystrophy: A Pilot Study. Evid Based Complement Alternat Med. 2019 May 29;2019:8436325. doi: 10.1155/2019/8436325. PMID: 31275423; PMCID: PMC6560364.

https://www.sciencedirect.com/topics/medicine-and-dentistry/cellulite

Medical Disclaimer : The information included on this blog is for educational purposes only. It is not intended nor implied to be a substitute for professional medical advice. The reader should always consult his or her healthcare provider to determine the appropriateness of the information for their own situation or if they have any questions regarding a medical condition or treatment plan. Never disregard professional medical advice or delay in seeking it because of something you have read on this blog! Reading the information on this blog does not create a physician-patient relationship.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brown Fat vs White Fat vs Beige Fat: What You Need to Know About Weight Loss

scott@skywax.com (Scott Lucas) — Tue, 06 Sep 2022 19:15:38 GMT

Brown Fat vs White Fat vs Beige Fat:

You Need to Know About Weight Loss

Do you know the difference between brown fat, white fat, and beige fat? If not, don't worry – most people don't. But understanding the difference is important if you're trying to lose weight. In this blog post, we will discuss the three different types of fat and how they impact weight loss. We'll also provide tips on how to activate your brown fat and burn more calories!

White Fat

Most people are familiar with white fat. White fat is the type of fat that accumulates around our waistlines and thighs. It may be found throughout our organs, under our skin, and in the folds between our muscles. White fat is relatively inactive, meaning that it doesn't burn many calories. White fat stores energy in the form of triglycerides. It's also the kind of fat that we typically think of when we think of "bad" fats. White fat is highly efficient at storing energy, which is why it's so difficult to get rid of.

Brown Fat

Brown fat, as opposed to white fat, is much more active and is considered "the good fat". Brown fat has been found to help burn calories, and promote weight loss, and is present in both babies/small children as well as adults according to recent studies. Brown fat gets its name from its brown color, which is caused by the presence of more mitochondria. Mitochondria are responsible for producing energy, and thus, more mitochondria mean more calorie burning! This process is called thermogenesis. Brown fat is located throughout our necks, on and between our shoulder blades, near our kidneys, and along the back of our spine.

Beige Fat

Beige fat is a type of fat that is somewhere between white and brown fat. It is derived by a process called "browning" in which white fat cells are converted into brown fat cells. Beige fat shares characteristics of both white and brown fat. Like white fat, beige fat stores energy in the form of triglycerides. But, like brown fat, beige fat is also thermogenic. However, beige fat is not as efficient at burning calories as brown fat. Beige fat is also believed to help regulate blood sugar levels and improve insulin sensitivity.

So, what does this all mean for weight loss? Well, activation of brown fat has been shown to help with weight loss. When our body signals to brown fat to start burning calories, we are effectively burning more calories overall! This is why it's important to find ways to activate our brown fat. More recently, the "browning" of white adipose tissue or white fat has generated a lot of interest in the weight loss research world as a potential alternative to increase energy expenditure, which will aid in weight reduction.

Burn More Calories!

Here are a few tips to help you burn more calories by activating your brown fat and also stimulating the "browning" effect:

Exercise regularly: Exercise is one of the best ways it helps to keep them warm. Unlike white fat, brown fat is not very efficient at storing energy. Instead, it burns calories to generate heat.
Eat a healthy diet: A healthy diet is important for weight loss, but it can also help to activate your brown fat. Foods that are high in fiber and protein can help to increase the amount of energy your body burns.
Incorporating Practitioner Grade Supplements like Panax ginseng and Japanese hop into your diet can help activate brown fat cells, while bamboo tea is also beneficial in the "browning" effect.
Consuming strawberries, red and black raspberries, Omija fruit, cinnamon, germinated soybean germ, spirulina, broccoli seeds and sprouts, cauliflower, collard greens, cabbage, and reishi mushrooms to stimulate brown fat production. Green tea and Omija tea have both been shown to be beneficial in activating your brown fat.

So, there you have it! Brown fat vs white fat vs beige fat. We hope this blog post has helped to clear up any confusion and that you now have a better understanding of how weight loss works. Remember, exercise and a healthy diet are still the best ways to lose weight and keep it off for good! But, if you're looking for an extra edge, try incorporating some of the tips above to help activate your brown fat and "browning" effect. Good luck!

Weight loss is a complex process that involves many different factors. But, by understanding the role that brown fat plays, you can be one step closer to reaching your weight loss goals!

As always consult with your doctor or a Functional Medicine Practitioner before taking any supplements.

If you'd like to discover more healthful methods to reduce weight, check out my new book "Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers."

Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Dr. Marios Michael, DC, CNS, cFMP, 06/2022, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers, 1st edition, Austin, Bookbaby.

Jung, SJ., Kim, WL., Park, BH. et al. Effect of toxic trace element detoxification, body fat reduction following four-week intake of the Wellnessup diet: a three-arm, randomized clinical trial. Nutr Metab (Lond) 17, 47 (2020). https://doi.org/10.1186/s12986-020-00465-9

Lee MK, Lee B, Kim CY. Natural Extracts That Stimulate Adipocyte Browning and Their Underlying Mechanisms. Antioxidants (Basel). 2021 Feb 17;10(2):308. doi: 10.3390/antiox10020308. PMID: 33671335; PMCID: PMC7922619.

Vargas-Castillo A, Fuentes-Romero R, Rodriguez-Lopez LA, Torres N, Tovar AR. Understanding the Biology of Thermogenic Fat: Is Browning A New Approach to the Treatment of Obesity? Arch Med Res. 2017 Jul;48(5):401-413. doi: 10.1016/j.arcmed.2017.10.002. PMID: 29102386.

Zhu X, Du S, Yan Q, Min C, Zhou N, Zhou W, Li X. Dietary curcumin supplementation promotes browning and energy expenditure in postnatal overfed rats. Nutr Metab (Lond). 2021 Oct 30;18(1):97. doi: 10.1186/s12986-021-00625-5. PMID: 34717663; PMCID: PMC8557570.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Do Telomeres Influence Our Aging Process? According to New Research, Yes!

scott@skywax.com (Scott Lucas) — Mon, 22 Aug 2022 18:31:15 GMT

Do Telomeres Influence Our Aging Process? According to New Research, Yes!

It's not a surprise to anyone that we all want to prevent aging. Now, new research suggests that our telomeres may play a role in how quickly we age. What are telomeres, you ask? They are the protective caps on the ends of our chromosomes, and they play an important role in aging. The length of our telomeres has been shown to predict lifespan, so it's no wonder that scientists are interested in understanding more about them! In this blog post, we will explore the latest research on telomeres and aging. Stay tuned for exciting updates!

What are telomeres?

Telomeres are tiny caps of DNA at the end of chromosomes and their main function is to protect the chromosome from DNA damage much like our shoelaces have aglets (or plastic tips) to prevent the shoelace from fraying. Chromosomes contain our DNA and our DNA is what makes us who we are. Telomeres prevent our DNA from being damaged or lost as cells divide.

However, telomeres get shorter with each cell division. When they are too short, the cell is no longer able to divide and dies. This is how we age. But what if we could lengthen our telomeres, and in turn, reverse aging? According to new research, it might be possible.

Do telomeres control our aging process?

New research suggests that telomeres may play a role in how quickly we age. One study found that telomere length was associated with mortality risk in older adults. The study found that shorter telomeres were linked to an increased risk of death from any cause, while longer telomeres were linked to a decreased risk of death. Telomeres may also play a role in the aging process by affecting cell division and repair. In one study, telomere length was found to be associated with skin aging. The study found that shorter telomeres were linked to increased skin aging, while longer telomeres were linked to decreased skin aging.

What is telomerase?

Telomerase is an enzyme that's produced naturally in our cells, but its levels decrease as we age. Telomerase has the ability to add telomere repeats to the end of our chromosomes, which can lengthen telomeres and prevent them from getting too short.

While the findings of this study are exciting, it's important to note that telomerase is not a magic bullet for aging. The study found that telomeres were only lengthened by about 20 percent, and telomere length is just one factor that contributes to aging. However, the findings of this study suggest that telomeres may play a role in aging, and telomerase may be a potential treatment for age-related diseases.

How to meausre Telomeres?

The telomere complex can be measured using a telomere assay. A telomere assay is a laboratory test that measures the length of telomeres in cells. The test can be used to measure telomere length in blood cells, skin cells, or any other type of cell. A telomere assay is a simple and relatively inexpensive test that can be used to measure telomere length.

Is it possible to naturally lengthen telomeres?

You can lengthen telomeres naturally in multiple ways, some of which are:

Exercising regularly
Maintaining a healthy diet
Taking antioxidants
Stress reduction management

Telomeres and supplements

So if you're looking for a way to turn back the clock, telomeres might be the answer. There are a few supplements on the market that claim to lengthen telomeres, so do your research and find one that works for you. Here is the list of supplements :

- TA-65 from a company called TA Sciences

- TRF from a company called Telos95.

- Advanced Telomere Support by Advanced Bionutritionals

- Telogenesis by LCR Health

- Elysium Health Basis from a company called Elysium Health.

- Telomere Health by Cellhealth

Telomeres and Cancer

Cancer cells differ from healthy cells in that they don't have a set lifespan. One of the interesting features of cancer cells is that they maintain long telomeres, which allows them to keep dividing even though they should theoretically reach the end of their lifespan. This is one of the mechanisms by which cancer cells mislead the human body into believing they should keep growing and replicating.

If you have a history of cancer or telomere diseases, it is wise to consult with your doctor before using any telomere-related supplements. Always consult your physician or a licensed Functional Medicine Practitioner before taking any supplements.

Are telomeres the fountain of eternal youth?

The jury is still out on whether telomeres are the fountain of eternal youth. More research is needed to confirm the findings of this study. However, the findings of several studies suggest that telomeres may play a role in aging, and telomerase may be a potential treatment for age-related diseases. There are many factors involved in aging and telomeres are one piece of the aging jigsaw puzzle.

Please note that this blog post is for informational purposes only and does not constitute medical advice. Please consult a medical professional if you have any questions or concerns.

In my new book, "Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers," you can learn more about telomeres and how to extend your lifespan.

If you want to learn more about how to harness your genetic powers this book is a must-read! Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Dr. Marios Michael, DC, CNS, cFMP, 06/2022, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers, 1st edition, Austin, Bookbaby.

Shammas MA. Telomeres, lifestyle, cancer, and aging. Curr Opin Clin Nutr Metab Care. 2011 Jan;14(1):28-34. doi: 10.1097/MCO.0b013e32834121b1. PMID: 21102320; PMCID: PMC3370421.

Vaiserman Alexander, Krasnienkov Dmytro.Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives.Frontiers in Genetics.Volume11,2021. DOI=10.3389/fgene.2020.630186.ISSN=1664-8021

Karen Anne Mather, Anthony Francis Jorm, Ruth Adeline Parslow, Helen Christensen, Is Telomere Length a Biomarker of Aging? A Review, The Journals of Gerontology: Series A, Volume 66A, Issue 2, February 2011, Pages 202–213.

https://doi.org/10.1093/gerona/glq180

https://www.hopkinsmedicine.org/news/newsroom/news-releases/accurate-telomere-length-test-influences-treatment-decisions-for-certain-diseases

https://www.healthycell.com/blogs/articles/should-you-be-taking-a-telomerase-supplement-every-day

https://www.elysiumhealth.com

Arsenis NC, You T, Ogawa EF, Tinsley GM, Zuo L. Physical activity and telomere length: Impact of aging and potential mechanisms of action. Oncotarget. 2017 Jul 4;8(27):45008-45019. doi: 10.18632/oncotarget.16726. PMID: 28410238; PMCID: PMC5546536.

https://med.stanford.edu/news/all-news/2015/01/telomere-extension-turns-back-aging-clock-in-cultured-cells.html

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Top 10 Reasons Everyone Needs a Functional Medicine Provider

scott@skywax.com (Scott Lucas) — Fri, 12 Aug 2022 21:57:57 GMT

The Top 10 Reasons Everyone Needs a Functional Medicine Provider

Functional Medicine is becoming more and more popular, and for good reason! This type of medicine focuses on identifying and addressing the root causes of disease, rather than just treating the symptoms. If you are looking for an alternative to traditional medicine, or if you are struggling with a chronic health condition, functional medicine may be the right choice for you. In this blog post, we will discuss the top 10 reasons everyone should see a Functional Medicine provider.

Functional Medicine is a personalized, whole-person approach to health care. Rather than simply treating the symptoms of disease, Functional Medicine providers work to identify and address the underlying causes of illness. This holistic approach often leads to better health outcomes and improved quality of life for patients.

There are many reasons why someone might choose to see a Functional Medicine provider.

Here are the top ten reasons:

-Functional Medicine providers focus on prevention.

By identifying and addressing the root causes of disease, Functional Medicine providers can help prevent illness before it starts. This is a key difference between traditional and Functional Medicine approaches. Traditional medicine often focuses on treating illness after it has already developed, while Functional Medicine works to prevent illness from occurring in the first place.

-Functional Medicine providers take a holistic approach.

Functional Medicine providers view each patient as a unique individual, rather than just a collection of symptoms. This means that they take into account a wide range of factors when developing a treatment plan, including lifestyle, diet, and environmental factors. This holistic approach often leads to better health outcomes and improved quality of life for patients.

-Functional Medicine providers treat the whole person, not just the symptoms.

Traditional medicine often focuses on treating the symptoms of disease, rather than the underlying causes. This can lead to a never-ending cycle of symptom management, rather than

true healing. Functional Medicine providers, on the other hand, focus on treating the whole person. By addressing the underlying causes of disease, they can help patients achieve lasting health and wellness.

-Functional Medicine providers use a systems-based approach.

Functional medicine providers understand that the human body is a complex system, made up of interconnected systems. This systems-based approach leads to a more comprehensive understanding of each patient’s unique health needs.

-Functional Medicine providers individualize treatment plans.

Because each person is unique, functional medicine providers tailor treatment plans to meet the specific needs of each patient. This personalized approach often leads to better health outcomes and improved quality of life.

-Functional Medicine providers use evidence-based treatments.

Functional Medicine providers use a variety of evidence-based treatments, including diet, lifestyle changes, and supplements. It also considers the dynamic balance of gene-environment interactions.This scientific approach leads to more effective and sustainable results.

-Functional Medicine providers are trained in both traditional and alternative therapies.

Functional Medicine providers are often trained in both traditional and alternative therapies. This allows them to offer a more comprehensive approach to care.

-Functional Medicine providers work with you to develop a treatment plan.

Functional Medicine providers work with you to develop a treatment plan that meets your specific needs and goals. Because Functional Medicine is preventative, integrative, and personalized it often leads to better health outcomes and improved quality of life for patients.

-Functional Medicine providers use Practitioner-Grade supplements

Functional Medicine providers use high-quality and purity, Practitioner-Grade supplements to support their patients. This ensures that patients are getting the best possible care.

-Functional Medicine is an emerging field.

Functional Medicine is an emerging field of medicine that is still evolving. This means that there is a lot of potential for new and innovative treatments. As more research is conducted, the potential benefits of functional medicine will become even more clear.

If you’re looking for a more comprehensive approach to your health care, a Functional Medicine provider may be right for you. Contact a Functional Medicine provider today to learn more about how this unique approach to care can help you achieve lasting health and wellness.

If you'd like to learn more about Functional Medicine, I highly recommend my new book, " Understanding Genomics ; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers".

This book is a must-read if you want to learn how to control your genetic destiny! Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Dr. Marios Michael, DC, CNS, cFMP, 06/2022, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers, 1st edition, Austin, Bookbaby.

Bland J. Defining Function in the Functional Medicine Model. Integr Med (Encinitas). 2017 Feb;16(1):22-25. PMID: 28223904; PMCID: PMC5312741.

Jones DS, Quinn S. Textbook of Functional Medicine. Gig Harbor, WA: Institute for Functional Medicine; 2010.

Bland J. Functional Medicine: An Operating System for Integrative Medicine. Integr Med (Encinitas). 2015 Oct;14(5):18-20. PMID: 26770161; PMCID: PMC4712869.

Beidelschies M, Alejandro-Rodriguez M, Guo N, et alPatient outcomes and costs associated with functional medicine-based care in a shared versus individual setting for patients with chronic conditions: a retrospective cohort studyBMJ Open 2021;11:e048294. doi: 10.1136/bmjopen-2020-048294

Droz N, Hanaway P, Hyman M, Jin Y, Beidelschies M, Husni ME (2020) The impact of functional medicine on patient-reported outcomes in inflammatory arthritis: A retrospective study. PLoS ONE 15(10): e0240416. https://doi.org/10.1371/journal.pone.0240416

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Surprising Connection between Gut Health and Mindset

scott@skywax.com (Scott Lucas) — Mon, 08 Aug 2022 18:06:56 GMT

The Surprising Connection between Gut Health and Mindset

Did you know that your gut health affects your mindset? When our gut is healthy, we tend to be happier and more positive. But when our gut is unhealthy, we can experience a lot of negative emotions like anxiety and depression. In this blog post, we will discuss the connection between gut health and mindset, and how you can improve both by making some simple changes to your diet and lifestyle.

The gut-brain axis

So how exactly does gut health affect mental health? Well, it all starts with the gut-brain axis. This is a bidirectional communication system that allows information to be passed between the gut and the brain. The gut-brain axis is made up of the nervous system, the endocrine system, the immune system, and the gut microbiome. These systems work together to regulate mood, anxiety, immunity, and stress levels.

The gut microbiota has been shown to influence the gut-brain axis. The microbiome is composed of trillions of microbes, including bacteria, viruses, fungi, and protozoa. These microbes are essential for gut health and have a profound impact on the gut-brain axis. The gut microbiome influences the development and function of the brain, and the brain influences the composition of the gut microbiome. For example, gut bacteria can produce neurotransmitters that affect the brain. They can also alter the way the body responds to stress hormones. These changes can then lead to changes in mood and behavior.

Psychobiotics!

There is a growing body of evidence to suggest that gut health plays a role in mental health. For example, studies have shown that probiotics can improve mood and cognitive function. Probiotics are live microorganisms that have a beneficial effect on gut health. Lactobacillus rhamnosus, Lactobacillus plantarum, and Bifidobacterium adolescentis for example are probiotic strains that can produce the neurotransmitter GABA. Neurotransmitters are chemical messengers that connect nerve cells. Serotonin, dopamine, and GABA are examples of neurotransmitters. GABA helps to regulate brain activity and can calm anxiety. The researchers found that the mice that consumed these probiotics had changes in their brain chemistry. The levels of GABA were increased and the mice were more relaxed.

The Vagus Nerve

The microbiota, the gut, and the brain communicate through the microbiota-gut-brain axis in both directions via the autonomic nervous system. The vagus nerve, the principal component of the parasympathetic nervous system, is a mixed nerve composed of 80% input sensory fibers (transmitting signals to the central nervous system) and 20% output motor fibers (transmitting signals in the opposite direction). It runs from the stomach to the brain and connects us to our emotions. This nerve is involved in gut-brain communication and has a significant impact on our mood. The vagus nerve sends messages directly from the gut to the brain. This nerve controls messages to the gut as well as other vital organs, like the heart and lungs.

Gut health

So, what is gut health? Gut health is the condition of our digestive system. This includes the stomach, small intestine, large intestine, and other organs like the liver, gallbladder, and pancreas. There are more than five hundred distinct species of bacteria in the gut, and it is home to trillions of microorganisms. These gut bacteria are essential for gut health. They help us digest food, absorb nutrients, and produce vitamins and minerals. Gut bacteria also play a role in immunity, inflammation, and the development of the gut-brain axis.

Studies have shown that gut health is linked to our DNA. Gut bacteria can affect the expression of our genes! Microbiomes can influence which genes are turned on or off, amplified, or silenced. Because our DNA is the blueprint for life, our gut health can have a significant impact on our mood, actions, and even thoughts.

So how can we improve our gut health?

When we think about gut health, we often think about the bacteria in our gut. But our gut health is also influenced by the foods we eat, the stress we experience, and the toxins we're exposed to. All of these factors can impact our gut microbiome, which in turn can influence our mood and mental health. There are a few simple things you can do:

-Eat more fiber. Fiber is essential for gut health, as it helps keep our digestive system moving smoothly. Foods high in fiber include fruits, vegetables, whole grains, and legumes.

-Cut out processed foods. Processed foods are full of sugar and unhealthy fats that can damage gut bacteria. Instead, opt for fresh, whole foods that are easy on the digestive system.

-Get enough sleep. Sleep is important for gut health, as it allows our bodies to repair and regenerate. Make sure to get at least seven hours of sleep each night.

-Reduce stress. Stress can damage gut bacteria, affect gut motility and increase gut permeability, which can lead to inflammation. Try to relax with some deep breathing or meditation.

-Avoid a diet consisting of large amounts of sugar and fat because it affects neurotransmitter metabolism and subsequently brain function by altering the gut microbiota. Studies have shown that gut microbiota composition is different between people with depression and those without.

- Take Practitioner-Grade Prebiotic and Probiotic Supplements.

-Eat probiotic-rich foods like yogurt, sauerkraut, and kimchi.

-Exercise regularly.

-Consuming prebiotic-rich foods like garlic, onions, bananas, and oats can also help feed the good bacteria in your gut.

-A 10-day detox or a 28-day detox is recommended. Toxins can cause havoc and disrupt the beneficial gut flora. Try doing a cleanse or detox once or twice per year to help keep your gut healthy and balanced.

key points

Gut cells outnumber human cells ten to one.
The gut microbiome contains over 100 trillion microorganisms and over 500 different species of bacteria.
The gut has been nicknamed the "second brain".
There is a gut-brain connection and it's a two-way street.
Gut bacteria can influence the way we think and feel.
Changes in gut health can lead to changes in mood and behavior.
Prebiotics and probiotics have the potential to enhance gut health and mental well-being.
You can improve your gut health by eating a healthy diet, exercising, detoxing, and managing stress levels.

Conclusion

The connection between gut health and mental health is complex, and more research is needed to understand the full extent of the gut-brain axis. However, the growing body of evidence suggests that gut health plays an important role in mental health. So next time you're feeling down, try reaching for a probiotic-rich food or supplement instead of unhealthy comfort foods. Your gut (and mind) will thank you!

If you are struggling with gut issues or mental health issues, please reach out to a qualified healthcare professional or a Functional Medicine Practitioner to help you.

If you'd like to learn more about gut health, I highly recommend my new book, " Understanding Genomics ; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers".

This book is a must-read if you want to learn how to control your genetic destiny! Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Dr. Marios Michael, DC, CNS, cFMP, 06/2022, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers, 1st edition, Austin, Bookbaby.

https://www.nccih.nih.gov/news/events/4-fast-facts-about-the-gutbrain-connection

Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol. 2015 Apr-Jun;28(2):203-209. PMID: 25830558; PMCID: PMC4367209.

Bonaz Bruno, Bazin Thomas, Pellissier Sonia.The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis. Frontiers in Neuroscience. VOL 12,2018

https://www.frontiersin.org/articles/10.3389/fnins.2018.00049 DOI=10.3389/fnins.2018.00049. ISSN=1662-453X

Mittal R, Debs LH, Patel AP, Nguyen D, Patel K, O'Connor G, Grati M, Mittal J, Yan D, Eshraghi AA, Deo SK, Daunert S, Liu XZ. Neurotransmitters: The Critical Modulators Regulating Gut-Brain Axis. J Cell Physiol. 2017 Sep;232(9):2359-2372. doi: 10.1002/jcp.25518. Epub 2017 Apr 10. PMID: 27512962; PMCID: PMC5772764.

Guo, Y., Zhu, X., Zeng, M. et al. A diet high in sugar and fat influences neurotransmitter metabolism and then affects brain function by altering the gut microbiota. Transl Psychiatry 11, 328 (2021). https://doi.org/10.1038/s41398-021-01443-2

https://www.sciencedirect.com/science/article/abs/pii/S0168010221000754

McVey Neufeld, KA., Bienenstock, J., Bharwani, A. et al. Oral selective serotonin reuptake inhibitors activate vagus nerve dependent gut-brain signalling. Sci Rep 9, 14290 (2019). https://doi.org/10.1038/s41598-019-50807-8

Del Toro-Barbosa M, Hurtado-Romero A, Garcia-Amezquita LE, García-Cayuela T. Psychobiotics: Mechanisms of Action, Evaluation Methods and Effectiveness in Applications with Food Products. Nutrients. 2020 Dec 19;12(12):3896. doi: 10.3390/nu12123896. PMID: 33352789; PMCID: PMC7767237.

Yunes RA, Poluektova EU, Vasileva EV, Odorskaya MV, Marsova MV, Kovalev GI, Danilenko VN. A Multi-strain Potential Probiotic Formulation of GABA-Producing Lactobacillus plantarum 90sk and Bifidobacterium adolescentis 150 with Antidepressant Effects. Probiotics Antimicrob Proteins. 2020 Sep;12(3):973-979. doi: 10.1007/s12602-019-09601-1. PMID: 31677091.

Yunes RA, Poluektova EU, Dyachkova MS, Klimina KM, Kovtun AS, Averina OV, Orlova VS, Danilenko VN. GABA production and structure of gadB/gadC genes in Lactobacillus and Bifidobacterium strains from human microbiota. Anaerobe. 2016 Dec;42:197-204. doi: 10.1016/j.anaerobe.2016.10.011. Epub 2016 Oct 26. PMID: 27794467.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

15 Health Conditions Linked to Your Gut and an Imbalanced Microbiome: How to Restore Balance for Better Health

scott@skywax.com (Scott Lucas) — Fri, 05 Aug 2022 17:50:59 GMT

15 Health Conditions Linked to Your Gut and an Imbalanced Microbiome: How to Restore Balance for Better Health

Your gut health is extremely important, and when it is imbalanced, it can lead to several health conditions. In this blog post, we will discuss 15 health conditions that are linked to an imbalanced microbiome. We will also provide tips on how you can restore balance in your gut and improve your overall health!

We all know how important gut health is for our general health, but did you know that an imbalanced microbiota might cause a slew of illnesses? Here are 15 conditions that have been linked to an imbalanced microbiome:

Allergies and asthma
Autoimmune diseases
Cancer
Cardiovascular disease
Depression and anxiety
Digestive disorders: irritable bowel syndrome (IBS), Small intestinal bacterial overgrowth (SIBO), and inflammatory bowel disease (IBD).
Eczema, acne, and psoriasis
Fatigue syndrome
Hormonal imbalances: Infertility and PCOS
Insulin resistance and type II diabetes
Migraines and headaches
Neurodegenerative diseases: Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis.
Nonalcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH)
Obesity

Recommendations

There are a few things you can do to restore balance in your gut and improve your overall health. First, focus on eating a nutrient-dense diet that includes plenty of fresh fruits, vegetables, and whole grains. The Mediterranean diet is particularly beneficial for gut health. Second, make sure to get enough high-quality probiotics , prebiotics , and fermented foods. Probiotics are live bacteria that can help restore balance to your gut. Prebiotics are indigestible fibers that act as food for probiotics. Fermented foods are a great source of both probiotics and prebiotics. Third, eliminating processed foods, sugars, and other inflammatory foods that can trigger an imbalance in gut bacteria. Keeping a daily food diary can help identify food sensitivities. Fourth, avoiding antibiotics when possible is also key, as they can kill both good and bad bacteria in your gut. If you must take them, make sure to supplement with probiotics to help restore balance. Always consult with your healthcare practitioner before stopping or starting any medications. Finally, make sure to get enough sleep and manage stress levels as both can hurt gut health.

By following these tips, you can help restore balance in your gut and improve your overall health! If you are struggling with any chronic health conditions, work with a Functional Medicine Practitioner to find the best treatment plan for you.

If you'd like to learn more about microbiota and gut health, I highly recommend my new book , "Understanding Genomics ; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers".

This book is a must-read if you want to learn how to control your genetic destiny! Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Dr. Marios Michael, DC, CNS, cFMP, 06/2022, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers, 1st edition, Austin, Bookbaby.

Xu H, Liu M, Cao J, Li X, Fan D, Xia Y, Lu X, Li J, Ju D, Zhao H. The Dynamic Interplay between the Gut Microbiota and Autoimmune Diseases. J Immunol Res. 2019 Oct 27;2019:7546047. doi: 10.1155/2019/7546047. PMID: 31772949; PMCID: PMC6854958.

Álvarez-Arraño V, Martín-Peláez S. Effects of Probiotics and Synbiotics on Weight Loss in Subjects with Overweight or Obesity: A Systematic Review. Nutrients. 2021 Oct 17;13(10):3627. doi: 10.3390/nu13103627. PMID: 34684633; PMCID: PMC8540110.

Clapp M, Aurora N, Herrera L, Bhatia M, Wilen E, Wakefield S. Gut microbiota's effect on mental health: The gut-brain axis. Clin Pract. 2017 Sep 15;7(4):987. doi: 10.4081/cp.2017.987. PMID: 29071061; PMCID: PMC5641835.

He Song, Li Hao, Yu Zehui, Zhang Faming, Liang Sicheng, Liu Hang, Chen Hongwei, Lü MuHan. The Gut Microbiome and Sex Hormone-Related Diseases. Frontiers in Microbiology.Vol. 12 2021. https://www.frontiersin.org/articles/10.3389/fmicb.2021.711137 DOI=10.3389/fmicb.2021.711137 .ISSN=1664-302X

Tang WH, Kitai T, Hazen SL. Gut Microbiota in Cardiovascular Health and Disease. Circ Res. 2017 Mar 31;120(7):1183-1196. doi: 10.1161/CIRCRESAHA.117.309715. PMID: 28360349; PMCID: PMC5390330.

Vivarelli S, Salemi R, Candido S, Falzone L, Santagati M, Stefani S, Torino F, Banna GL, Tonini G, Libra M. Gut Microbiota and Cancer: From Pathogenesis to Therapy. Cancers (Basel). 2019 Jan 3;11(1):38. doi: 10.3390/cancers11010038. PMID: 30609850; PMCID: PMC6356461.

Fujimura KE, Lynch SV. Microbiota in allergy and asthma and the emerging relationship with the gut microbiome. Cell Host Microbe. 2015 May 13;17(5):592-602. doi: 10.1016/j.chom.2015.04.007. PMID: 25974301; PMCID: PMC4443817.

Nagao-Kitamoto H, Kitamoto S, Kuffa P, Kamada N. Pathogenic role of the gut microbiota in gastrointestinal diseases. Intest Res. 2016 Apr;14(2):127-38. doi: 10.5217/ir.2016.14.2.127. Epub 2016 Apr 27. PMID: 27175113; PMCID: PMC4863046.

Wang R, Tang R, Li B, et al. Gut microbiome, liver immunology, and liver diseases. Cell Mol Immunol 2021;18(1):4-17.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Reframing the Autoimmune Process with Functional Medicine and Genomics

scott@skywax.com (Scott Lucas) — Mon, 01 Aug 2022 13:00:08 GMT

Reframing the Autoimmune Process with Functional Medicine and Genomics

Have you ever wondered why, despite our best efforts to eat healthily and take care of ourselves, some people still develop autoimmune conditions? Or why two people with the same diagnosis can have vastly different symptoms? The answer lies in the unique way that each of us experiences the autoimmune process. With the help of Functional Medicine and Genomics, we can now begin to reframe the autoimmune process in a more individualized way. In this blog post, we will explore how Functional Medicine and Genomics can help us understand and treat our unique autoimmune conditions.

Autoimmune conditions are on the rise. It is estimated that autoimmune diseases affect over 50 million Americans. That’s one in every six people! And while the exact cause of autoimmune conditions is still unknown, we do know that they are complex and often involve a combination of environmental and genetic factors.

What is an autoimmune condition? Simply put, it is a condition in which your immune system mistakenly attacks your healthy tissues. This can happen for a variety of reasons, but most often it is because the body cannot distinguish between foreign invaders (like bacteria or viruses) and healthy cells. When this happens, the immune system produces antibodies that attack and destroy the healthy tissue.

Autoimmune conditions can affect any part of the body, and they often result in a wide range of symptoms. Celiac disease, rheumatoid arthritis, type 1 diabetes, lupus, thyroid disease, and Crohn's disease are just a few examples of autoimmune diseases. Both the gut and the genome have distinct immunological reactions that are unique to each individual, resulting in over a hundred different types of autoimmune diseases.

Functional Medicine

So how can Functional Medicine and Genomics help us reframe the autoimmune process? Functional Medicine is an approach to healthcare that focuses on finding the root cause of disease. Rather than simply treating symptoms, Functional Medicine practitioners look for underlying imbalances that may be contributing to illness. Gut health microbiota, for example, has been linked to autoimmune diseases. When the gut is out of balance, the immune system can go into overdrive trying to protect the body against perceived threats. This can lead to chronic inflammation and an increased risk of autoimmune disease.

Genomics

The human genome is the complete set of genetic instructions for a person. It is the blueprint for living. In recent years, advances in DNA sequencing technology have made it possible to map an individual's entire genome. This has given rise to the field of Genomic Medicine, which is using this information to develop more personalized approaches to healthcare.

In the case of autoimmune conditions, Genomic Medicine can help us understand why some people are more susceptible to these diseases than others. For example, HLA, IL23R, TNFAIP3, and IL2RA genes have been connected to an increased risk of autoimmune illnesses. We can take preventative measures against autoimmune diseases by learning about our genetic make-up and implementing preventative strategies. We can also study how our genes interact with our environment to influence the development of autoimmune conditions. Learning about someone's DNA allows us to develop more tailored and efficient therapies for these problems. Knowing your genomic vulnerabilities allows you to take a proactive approach toward greater health.

Conclusion

Functional Medicine and Genomics are powerful tools that can help us understand our own unique experiences of the autoimmune process. By reframing the way we think about autoimmune conditions, we can begin to find more effective ways to treat and prevent them. This holistic approach often involves looking at the body as a whole system, rather than isolated parts.

If you want to learn more about how Functional Medicine and Genomics may assist you on your health and wellness journey, talk with a Functional Medicine Provider that specializes in Genomics .

If you'd like to learn more about autoimmune diseases, gut health, and Genomics, I've just released a book entitled " Understanding Genomics : How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers."

This book is a must-read if you want to learn how to control your genetic destiny! Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Dr. Marios Michael, DC, CNS, cFMP, 06/2022, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers, 1st edition, Austin, Bookbaby.

Mazzone, R., Zwergel, C., Artico, M. et al. The emerging role of epigenetics in human autoimmune disorders. Clin Epigenet 11, 34 (2019). https://doi.org/10.1186/s13148-019-0632-2

Surace Anna Elisa Andrea, Hedrich Christian M. Role of Epigenetics in Autoimmune/Inflammatory Disease.Frontiers in Immunology. Vol. 10, 2019 DOI=10.3389/fimmu.2019.01525

Xu H, Liu M, Cao J, Li X, Fan D, Xia Y, Lu X, Li J, Ju D, Zhao H. The Dynamic Interplay between the Gut Microbiota and Autoimmune Diseases. J Immunol Res. 2019 Oct 27;2019:7546047. doi: 10.1155/2019/7546047. PMID: 31772949; PMCID: PMC6854958.

Fasano A. Leaky gut and autoimmune diseases. Clin Rev Allergy Immunol. 2012;42(1):71-78. doi: 10.1007/s12016-011-8291-x .
Yamamoto K, Okada Y. Shared genetic factors and their causality in autoimmune diseases. Ann Rheum Dis. 2019;78(11):1449-1451. doi: 1136/annrheumdis-2019-215099

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Metabolic Detoxification and Cellular Rejuvenation: How to Boost Your Anti-Aging Efforts

scott@skywax.com (Scott Lucas) — Thu, 28 Jul 2022 16:08:55 GMT

Metabolic Detoxification and Cellular Rejuvenation: How to Boost Your Anti-Aging Efforts

It's no secret that the key to looking and feeling young is keeping our cells healthy. We all know that we need to eat right, exercise, and get enough sleep to maintain our health as we age. But what many people don't realize is that another important factor in anti-aging is metabolic detoxification. In this blog post, we will discuss how metabolic detoxification can help improve cellular health and reduce the signs of aging.

Metabolic Detoxification

Most people are familiar with the concept of detoxing the body. We often think of detoxes as restrictive diets or juice cleanses that we do to rid our bodies of toxins. While these methods can be beneficial, they are not the only way to detoxify the body. The body's natural method for detoxification, known as metabolic detoxification, is the preferred approach and is essential for optimal health.

Metabolic detoxification is the process by which the body breaks down and eliminates water and fat-soluble toxins as well as heavy metal toxins and organophosphates which are common in our environment. When our cells are healthy, they are better able to repair themselves and function properly. This means that they can fight off disease and aging more effectively.

Many factors can contribute to a build-up of toxins in the body, including poor diet, stress, and exposure to environmental toxins. When these toxins accumulate, they can cause damage to our cells and lead to various health problems. While our cells can repair themselves, over time they become less efficient at doing so. This is where detoxing comes in. Just as we clear out the junk from our homes to make them more livable, detoxing gives our cells a much-needed refresh.

Improving your Biological clock by reversing cellular damage

Detoxification is important for both preventing and reversing cellular damage. When we detoxify the body, we can eliminate toxins and reduce their damaging effects. This can lead to improved cellular health and a reduction in the signs of aging.

Metabolic detoxification and our DNA strands have a lot in common- both need the right environment and occasional tune-ups to perform their best. Each cell has a copy of our unique DNA blueprint, and just like our detoxification organs, our cells need the right environment and support to function optimally.

While we can't control everything that impacts our cells (think: pollution, UV radiation, viruses, toxins, etc.), there are some things we can do to give them a fighting chance. One of the best ways to support cellular health is by taking Practitioner-Grade supplements and Medical Food detox shakes that are designed to detoxify and rejuvenate cells. Detoxing with Practitioner- Grade supplements are appealing because they are of high quality and potency. This means they can make a difference in your health. These supplements provide the body with the nutrients it needs to detoxify effectively and may also help to reduce stress and promote a healthy gut environment. They are only available through a healthcare professional and are not sold in stores. The greatest benefit of detoxing with Practitioner-Grade supplements is that they may help boost your anti-aging efforts. That’s because detoxing helps to remove toxins that can damage cells and lead to premature aging. These supplements provide the body with the nutrients it needs to detoxify effectively. They can also help to reduce stress and promote a healthy gut environment.

If you're looking for an edge in the anti-aging game, consider adding some of these detoxifying and rejuvenating supplements to your regimen:

-Metagenics 10-day detox

-Metagenics 28-day detox

- Vitamin C: A powerful antioxidant that helps neutralize free radicals, support collagen production, and boost immune function

- Glutathione: A detoxifying compound that helps protect cells from damage and supports detoxification enzymes

- N-acetyl cysteine (NAC): An amino acid that helps replenish glutathione levels and support detoxification pathways

- Milk thistle: A liver-supporting herb that helps detoxify the body and protect cells from damage

If you are interested in boosting your anti-aging efforts, consider incorporating metabolic detoxification into your health routine. You may be surprised at just how much youthful vitality you can experience by simply taking care of your cells!

Ready to detoxify and rejuvenate your cells? Talk to your doctor or a Functional Medicine Practioner about which supplements are right for you.

Do you have any questions about metabolic detoxification or cellular rejuvenation? Leave a comment below and let us know! We are always happy to help in any way we can. Thanks for reading!

If you're interested in learning more about Metabolic Detoxification and cellular rejuvenation, I've just published a book called " Understanding Genomics : How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers."

This book is a must-read if you want to learn how to control your genetic destiny! Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Dr. Marios Michael, DC, CNS, cFMP, 06/2022, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers, 1st edition, Austin, Bookbaby.

https://info.metagenicsinstitute.com/detox-hub

https://doi.org/pnas.18036301

"Aronica L, Ordovas JM, Volkov A, Lamb JJ, Stone PM, Minich D, Leary M, Class M, Metti D, Larson IA, Contractor N, Eck B, Bland JS. Genetic Biomarkers of Metabolic Detoxification for Personalized Lifestyle Medicine. Nutrients. 2022 Feb 11;14(4):768. doi: 10.3390/nu14040768. PMID: 35215417; PMCID: PMC8876337.

https://www.lifeextension.com/protocols/metabolic-health/metabolic-detoxification

Romilly E. Hodges1 and Deanna M. Minich2,3. Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application, University of Bridgeport, 126 Park Avenue, Bridgeport, CT 07748, USA, Institute for Functional Medicine, 505 S. 336th Street, Suite 500, Federal Way, WA 98003, USA20 March 2015.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Love dairy but can't handle the lactose? Your DNA and Gut Health May Play a Role.

scott@skywax.com (Scott Lucas) — Mon, 25 Jul 2022 21:43:03 GMT

Love dairy but can't handle the lactose? Your DNA and Gut Health May Play a Role.

Do you suffer from lactose intolerance? You're not alone. According to the National Institute of Diabetes and Digestive and Kidney Diseases, about 75% of the world's population has a reduced ability to digest lactose. If you're one of those people, don't worry – there may be hope for you yet! Recent research suggests that your DNA and gut health may play a role in your ability to digest dairy products. Keep reading to learn more about this exciting new research and how it could help people with lactose intolerance.

Lactose intolerance is caused by a deficiency of the enzyme lactase, which is responsible for breaking down lactose into glucose and galactose. Lactase production typically decreases as we age, which is why many adults develop lactose intolerance. However, some people are born with congenital lactase deficiency, which means they never produce lactase in the first place.

Recent research has shown that a person's DNA may play a role in their ability to produce lactase. In one study, researchers looked at the DNA of people with and without lactose intolerance and found that those with lactose intolerance were more likely to have a certain genetic variant. This variant is thought to reduce the activity of the lactase enzyme, making it more difficult for the body to break down lactose.

The Science; Primary and secondary forms of lactose intolerance. Hang in there!

Primary lactose intolerance is due to a genetic mutation in the lactase-phlorizin hydrolase (LPH) enzyme which is encoded by the lactase (LCT) gene and is located on chromosome 2q21. Chromosomes are the structures that carry our DNA (blueprint for life) and each chromosome has anywhere from a few hundred to a few thousand genes. The LCT gene provides instructions for making an enzyme called beta-galactosidase. This enzyme is important for breaking down lactose into smaller sugars called glucose and galactose that can be easily absorbed by our gut cells. People with primary lactose intolerance have a mutation in the LCT gene that prevents their cells from making functional beta-galactosidase enzymes. As a result, lactose isn't broken down and absorbed properly, leading to gastrointestinal symptoms. This means that lactose isn't digested and it stays in the gut where it ferments and causes gas, bloating, abdominal pain, and diarrhea.

Secondary lactose intolerance is the more common form of the condition and is not caused by a mutation in the LCT gene. Instead, it's usually the result of another medical condition that damages the small intestine. The small intestine is the part of the digestive tract where most nutrient absorption occurs. The enzyme lactase is found in the small intestine, in the very tip of the tiny hair-like projections called microvilli, on the surface of the cells that line the intestine. Diseases that can damage the small intestine include celiac disease, Crohn's disease, and viral infections such as rotavirus. Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD) can also affect the small intestine. When the small intestine is damaged, it's not able to produce enough of the enzyme lactase. As a result, lactose isn't properly broken down and absorbed, leading to gastrointestinal symptoms.

Microbiota

The lining of the gut contains billions of bacteria, many of which are responsible for breaking down food and absorbing nutrients. People with lactose intolerance often have a different mix of gut bacteria than people who can digest lactose without any problems. This difference in gut bacteria is thought to contribute to the symptoms of lactose intolerance. The gut microbiome is like an extension of the human genome. This is because the microbes do many activities that directly affect the gut's physiology, including their ability to absorb lactose and other carbohydrates.

Infants and milk digestion

Many parents are concerned about how much milk their infants will consume. According to research, the enzyme LPH (encoded in the LCT gene ) reaches its peak activity during nursing and decreases its expression after weaning, resulting in lactase non-persistence (LNP) and adult milk and dairy product intolerance. However, a change or mutation that occurred approximately 7,000 years ago in Europe resulted in lactase persistence (LP), which allows people to digest milk. The variant is present in around 35% of the world's population!

Meds

Lactose intolerance can also be caused by certain medications, such as antibiotics and acid-lowering drugs. These medications have the potential to damage the lining of the small intestine, leading to a temporary decrease in lactase production. Symptoms usually go away when the person stops taking the medication. However, before you stop taking any medications, please consult with your doctor.

Lactose intolerance is different from milk allergy. Milk allergy is when your body mistakes milk for a harmful substance and produces IgE antibodies in response.

So, what does this all mean for those who are lactose intolerant? To avoid permanently removing dairy from your diet, it's important to distinguish between primary and secondary lactose intolerance. If you're lactose intolerant, it doesn't necessarily mean that you're allergic to milk or dairy products. It just means that your body can't process lactose properly.

What to do:

There are many things you can do to ease your symptoms.

You might consider getting a DNA lactose intolerance test and a Functional Medicine evaluation to discover the cause of your lactose intolerance.
Cut back on dairy: If you're consuming too much dairy, it can cause bloating, gas, and diarrhea. Try cutting back on dairy products and see if your symptoms improve. But for many people, that's not an ideal solution. After all, dairy contains important nutrients like calcium and vitamin D. You could choose to supplement to make up for the absence of dairy.
Choose lactose-free products: There are many lactose-free products available on the market today. Choose milk, cheese, and yogurt that are labeled "lactose-free."
Take lactase enzyme supplements: These supplements can help your body break down lactose. Be sure to take them before you eat or drink dairy products.
Take Prebiotics: Prebiotics can help the growth of beneficial bacteria in the gut.
Take probiotics: Probiotics are helpful bacteria that can improve gut health. They may also help relieve symptoms of lactose intolerance.
Try fermented milk products, such as yogurt and kefir, which are easier to digest than regular milk. They may also help improve gut health.
Take broad spectrum digestive enzymes to aid digestion and absorption, while reducing the gut burden. To increase their effectiveness, take them before you eat or drink dairy products.

Conclusion

There's no need to suffer from lactose intolerance. If you're still having trouble managing your symptoms, talk to your doctor or a Functional Medicine Doctor . He or she can help you find the best way to cope with lactose intolerance. You don't have to let it rule your life. With a little effort, you can still enjoy dairy products without discomfort.

Do you have any tips for dealing with lactose intolerance? Share them in the comments below!

If you'd like to learn more about lactose intolerance and gut health, I've recently published a book called " Understanding Genomics : How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers."

This book is a must-read if you want to learn how to control your genetic destiny! Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Dr. Marios Michael, DC, CNS, cFMP, 06/2022, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers, 1st edition, Austin, Bookbaby.

Anguita-Ruiz A, Aguilera CM, Gil Á. Genetics of Lactose Intolerance: An Updated Review and Online Interactive World Maps of Phenotype and Genotype Frequencies. Nutrients. 2020 Sep 3;12(9):2689. doi: 10.3390/nu12092689. PMID: 32899182; PMCID: PMC7551416.

https://doi.org/pnas.1803630115

https://medlineplus.gov/download/genetics/gene/lct.pdf

"Lactose Intolerance." National Institutes of Health. U.S. Department of Health and Human Services, 01 Mar. 2017. Web. 17 Apr. 2017.

"Lactose Intolerance." Mayo Clinic. Mayo Foundation for Medical Education and Research, 09 Feb. 2017. Web. 17 Apr. 2017.

"Dealing with Lactose Intolerance." Harvard Health Blog. Harvard Health Publications, 23 Dec. 2016. Web. 17 Apr. 2017.

"Lactose Intolerance." WebMD. WebMD, n.d. Web. 17 Apr. 2017.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Microbiome: How trillions of bacteria keep you healthy

scott@skywax.com (Scott Lucas) — Mon, 18 Jul 2022 20:15:30 GMT

The Microbiome: How trillions of bacteria keep you healthy

Did you know that there are trillions of bacteria living inside of you? These bacteria make up your microbiome, and they play a huge role in keeping you healthy! In this blog post, we will discuss the microbiome and how it affects your health. We will also talk about the benefits of having a healthy microbiome. So, if you're interested in learning more about the trillions of bacteria that keep you alive, keep reading!

What is it?

The microbiome is a hot topic in science these days. And for good reason - we're only just beginning to understand the role that trillions of bacteria play a crucial role in keeping us healthy. The microbiome is the collection of all microorganisms, such as bacteria, fungi, protozoa, and viruses, that reside on and in our bodies. The majority of them live in the gut.

DNA studies have found that we have more bacterial DNA than human DNA.- our bodies are home to around 100 trillion bacteria, compared to the mere 30 trillion human cells. These tiny organisms outnumber human cells by a factor of ten to one.

These bacteria are found in your gut, on your skin, and in other places. Most of them are harmless, and some are even beneficial. The microbes in our gut alone weigh about as much as our brain! We couldn't survive without them!

What does it do?

There are many different types of bacteria in the microbiome. Some of these bacteria are good for you and some of them are bad for you. You can have a healthy microbiome or an unhealthy microbiome. A healthy balanced microbiome boosts the immune system, protects against pathogenic bacteria, and helps with the management of IBS, Chron's Disease, and Ulcerative Colitis. It aids in weight loss, extends lifespan, protects against infections, produces vitamins like K, and B12, as well as enzymes, and breaks down food. These bacteria even influence our mood and mental health! There are many functions of the microbiome that we are only just beginning to understand.

An unhealthy microbiome can lead to weight gain, skin problems, allergies, autoimmune conditions, and even mental health issues. It can also make you more susceptible to infections, diseases, and cancer. So, it's important to keep your microbiome healthy! How do you do that?

How do I get a healthy microbiome?

There are many things that you can do to get and keep your microbiome healthy. For example, you can take prebiotic, probiotic, and postbiotic supplements. Prebiotics are a type of fiber that serves as food for the probiotics (beneficial bacteria) in your gut. Probiotics are live bacteria and yeasts that are good for your health, especially your digestive system. Postbiotics are compounds produced by probiotics during fermentation. Butyrate, for example, is a postbiotic that helps reduce inflammation, builds and strengthens the gut barrier function, and has even been shown to have anti-cancer effects. You may reduce your risk of having an unhealthy microbiome by not taking antibiotics unless necessary. Always check with your physician before stopping any medication.

Probioplex ® Intensive Care is one of the popular Practitioner-Grade Prebiotic formulas. According to Metagenics, Probioplex ® Intensive Care is an innovative formula produced by a temperature/pH-controlled micro-filtration process that yields biologically active immunoglobulins. These immunoglobulins support healthy intestinal immune activity. In addition, Probioplex Intensive Care supplies lactoferrin and lactoperoxidase, proteins that support intestinal health, and friendly bacteria such as lactobacilli and bifidobacteria.

When choosing a probiotic supplement, it is important to choose one that contains live, active cultures. The number of live bacteria in a supplement can vary from product to product. It is also important to make sure the supplement you choose has been tested for safety and effectiveness. Quality matters when it comes to probiotic supplements, so be sure to choose a reputable brand or a Practioner- Grade product

A balanced diverse microbiome is of utmost importance. Eating a varied diet rich in Fructooligosaccharides (FOS) such as onions, chicory, garlic, asparagus, bananas, and artichokes among many others can help promote the growth of healthy gut bacteria.

You can also maintain a healthy microbiome by eating a diet that is high in fiber and low in sugar. Fermented foods, such as yogurt, kimchi, sauerkraut, and pickles, can also help you keep a healthy gut flora. The Mediterranean diet has been shown to promote a healthy microbiome. This diet is high in fruits, vegetables, whole grains, and olive oil. It also includes moderate amounts of fish, poultry, and red wine. So if you're looking to maintain a healthy microbiome, eating a Mediterranean diet is a good place to start!

In addition to a healthy diet, there are other things you can do to keep your microbiome healthy such as exercise regularly, getting enough sleep, and managing stress.

Conclusion

The microbiome is unique to each individual, and it changes throughout our lifetime. Factors such as diet, medications, stress, and exposure to toxins can all impact the health of our microbiome. By taking care of your microbiome, you’re not only supporting your health, but also the health of the trillions of microbes that call your body home.

This is a brief introduction to our microbiome. I hope you find it interesting.

If you want to learn more about gut health and the microbiome, I've written a new book called " Understanding Genomics : How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers."

This book is a must-read if you want to learn how to control your genetic destiny! Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Dr. Marios Michael, DC, CNS, cFMP, 06/2022, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers, 1st edition, Austin, Bookbaby.
Quigley EM. Gut bacteria in health and disease. Gastroenterol Hepatol (N Y). 2013 Sep;9(9):560-9. PMID: 24729765; PMCID: PMC3983973. https://doi.org/pnas.1803630115
Ing Yang1,2,3†, Ji Pu1,2†, Shan Lu1,2,3†, Xiangning Bai1, Yangfeng Wu4, Dong Jin1,2,3, Yanpeng Cheng1, Gui Zhang1, Wentao Zhu1, Xuelian Luo1, Ramon Rosselló-Móra5 and Jianguo Xu1,2,3. Species-Level Analysis of Human Gut Microbiota With Metataxonomics, Front. Microbiol., 26 August 2020 https://www.frontiersin.org/articles/10.3389/fmicb.2020.02029/full
Sabater-Molina M, Larqué E, Torrella F, Zamora S. Dietary fructooligosaccharides and potential benefits on health. J Physiol Biochem. 2009 Sep;65(3):315-28. doi: 10.1007/BF03180584. PMID: 20119826.
https://www.metagenics.com
Jin Q, Black A, Kales SN, Vattem D, Ruiz-Canela M, Sotos-Prieto M. Metabolomics and Microbiomes as Potential Tools to Evaluate the Effects of the Mediterranean Diet. Nutrients. 2019; 11(1):207. https://doi.org/10.3390/nu11010207

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Our Thoughts Leave Genetic Marks: What This Means for You

scott@skywax.com (Scott Lucas) — Thu, 14 Jul 2022 17:16:49 GMT

Our Thoughts Leave Genetic Marks:

What This Means for You

Have you ever stopped to think about the implications of your thoughts? What if our thoughts left behind genetic markers? Well, it turns out that this is true! In a recent study, scientists found that when we have strong emotional reactions to something, it leaves a "memory" in our genes. This means that our thoughts can change our DNA! So what does this mean for you? Well, it's important to be aware of the power of your thoughts and how they can affect your health and well-being.

We are what we think

It has been said that we are what we think! If this is true, then our thoughts must leave some sort of mark on our DNA. And according to recent research, this may be the case. Scientists have found that certain thoughts and emotions can change the way our DNA is expressed. This process is known as “Epigenetics” and it refers to the way our environment can affect the way our genes are expressed. Epigenetics is a relatively new field of study, but it is already providing us with some incredible insights into how our thoughts and emotions can impact our health.

Epigenetic DNA markings resemble a barcode and are literally above our genes, and every time we think, it's like scanning that barcode. Genes are the recipe for life. If we think good thoughts, it's similar to adding healthy ingredients to our recipe. On the other hand, if we think negative thoughts, it's like adding toxins and poison to our recipe.

So what does this mean for you? Well, if you're constantly thinking negative thoughts, your DNA is going to reflect that. On the other hand, if you're constantly thinking positive thoughts, your DNA will reflect that as well. So what we think does matter! Take a moment to pause and focus on your breath the next time you're stressed or anxious. And remember, you have the power to change your DNA!

Emotional Trauma

For example, one study found that people who experienced emotional trauma in their lives had changes in their DNA that were passed down to their children. This means that the effects of trauma can actually be passed down through generations!

Fear

According to research fear can affect our DNA. The study found that people who were exposed to a lot of fear had changes in their DNA that made them more likely to experience anxiety and depression. A different study showed that fear can be passed on to future generations.

Meditation

Another study found that people who meditated had changes in their DNA that were associated with better health and well-being. These findings show us that our thoughts and emotions can have a very real impact on our genetic material.

Conclusion

In truth, no mind-body event is disconnected; thus genetics has been challenged. Our DNA is no longer fixed and sealed away; instead, it is dynamic and active. With each idea, word, and action you engage in, you're communicating with your genes. Experiences are recorded and remembered at the genetic level.

So what does this all mean for you? It means that your thoughts and emotions can influence your health and the health of your future children. It's important to be aware of the power of your thoughts and how they can affect your health and well-being. If you're going through a tough time, don't hesitate to reach out for help. And if you want to improve your health, consider incorporating some mindfulness into your daily routine. The power of your thoughts is more than just a saying, it's science!

Here are some things to keep in mind:

-Your thoughts leave genetic footprints

-Your thoughts can influence your genes.

-Your thoughts can impact your health and well-being.

-Your thoughts and emotions can influence the health of your future children.

-You have the power to change your DNA expression with your thoughts.

-You have the power to change your health, your appearance, and even your destiny.

This is just a brief overview of what our thoughts can do to our DNA. If you want to learn more, check out my new book "Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers."

This book is a must-read if you want to learn how to control your genetic destiny! Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Dr. Marios Michael, DC, CNS, cFMP, 06/2022, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers, 1st edition, Austin, Bookbaby.
Dora L. Costa,Noelle Yetter, and Heather DeSome, Intergenerational transmission of paternal trauma among US Civil War ex-POWs, October 15, 2018, 115 (44) 11215-11220 https://doi.org/pnas.1803630115
Feder A, Nestler EJ, Charney DS. Psychobiology and molecular genetics of resilience. Nat Rev Neurosci. 2009 Jun;10(6):446-57. doi: 10.1038/nrn2649. PMID: 19455174; PMCID: PMC2833107.
The Power of Thought: Our Thoughts Leave Genetic Marks, What This Means for You | The Chopra Center https://chopra.com/articles/how-your-genes-can-make-you-happier.
https://www.psychologytoday.com/us/blog/the-right-mindset/202002/five-thought-patterns-may-hurt-your-dna.
https://www.scientificamerican.com/article/fearful-memories-passed-down/
https://www.scientificamerican.com/article/how-parents-rsquo-trauma-leaves-biological-traces-in-children/.
Your Thoughts Can Literally Change The Expression Of Your Genes | Bruce Lipton Ph.D.
Gapp, K., van Steenwyk, G., Germain, P.L. et al. Alterations in sperm long RNA contribute to the epigenetic inheritance of the effects of postnatal trauma. Mol Psychiatry 25, 2162–2174 (2020). https://doi.org/10.1038/s41380-018-0271-6
Ali Jawaid, Katherina-Lynn Jehle, Isabelle M. Mansuy, Impact of Parental Exposure on Offspring Health in Humans, Trends in Genetics, 37, 4, (373-388), (2021). https://doi.org/10.1016/j.tig.2020.10.006

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Mediterranean Diet: How to Eat Like a Local

scott@skywax.com (Scott Lucas) — Mon, 11 Jul 2022 20:24:57 GMT

The Mediterranean Diet: How to Eat Like a Local

If you're looking for an excuse to travel to Europe, look no further than the Mediterranean diet! This delicious and healthy way of eating is popular all over the world, but it's most commonly found in countries like Italy, Greece, and Spain. So what is the Mediterranean diet? It's a way of eating that emphasizes fresh fruits and vegetables, whole grains, legumes, fish, and olive oil. In this blog post, we'll teach you how to eat like a local in one of these amazing countries. We'll also give you some tips on how to make the Mediterranean diet work for you!

The Mediterranean diet is all about fresh, seasonal ingredients. That means that you'll want to start by seeking out the freshest fruits and vegetables that are in season. Head to your local farmer's market or grocery store and stock up on whatever looks good! tomatoes, eggplant, zucchini, garlic, onions, peppers, lemons, and oranges are all great options. Once you have your produce, it's time to start cooking!

One of the best things about the Mediterranean diet is that it's incredibly versatile. There are so many different ways to prepare fruits and vegetables, so you can never get bored. One of our favorite ways to cook veggies is to roast them in the oven. This brings out their natural sweetness and makes them extra delicious. Another great option is to grill your veggies on the barbecue. This is a popular way to cook in the Mediterranean, and it's perfect for summertime.

Of course, no meal is complete without some protein. The Mediterranean diet typically relies on fish as its main source of protein. This is great news for seafood lovers, but what if you're not a fan of fish? Don't worry - there are plenty of other options. Chicken, lamb, and beef are all commonly eaten in the Mediterranean. If you're looking for a vegetarian option, tofu and tempeh make great substitutes for meat.

Last but not least, no Mediterranean meal is complete without a little bit of olive oil. This healthy fat is a key component of the diet, and it's what gives many dishes their signature flavor. However, a good rule of thumb is to use olive oil for flavor, not for cooking. When olive oil is heated at high temperatures, it will smoke and become unpleasantly bitter. Instead, use it to finish a dish by drizzling it over the top after it's already cooked.

According to recent research, the Mediterranean diet is our DNA's and Genome's favorite diet. It has been linked to a decreased risk of heart disease, stroke, metabolic syndrome, diabetes, depression, and cancer. It has also been found to improve cognitive function, memory, and even a longer life span! It should come as no surprise that the Mediterranean diet has won numerous accolades and is regarded by US News & World Report to be the "No. 1 Best Overall Diet" for the fifth year in a row.

The Mediterranean diet is a delicious and healthy way of eating that can be enjoyed by everyone. Following the tips in this blog post, it will ensure that you're getting the most health benefits possible. And when it comes to dressing your salad, simple olive oil and vinegar combination is all you need. Be sure to use a good quality extra virgin variety. Trust us, you'll love it!

Now that you know how to eat like a local in the Mediterranean, it's time to start planning your trip! This region has so much to offer, from stunning beaches to ancient ruins. And of course, the food is not to be missed. So what are you waiting for? Start packing your bags - and don't forget your sunscreen!

Do you have any favorite Mediterranean recipes? We'd love to hear from you in the comments below!

If you want to learn more about the Mediterranean diet check out chapter #5 of my new book " Understanding Genomics ; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers."

This book is a must-read if you want to learn how to control your genetic destiny! Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Dr. Marios Michael, DC, CNS, cFMP, 06/2022, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers, 1st edition, Austin, Bookbaby.

Gwynne M, Mounsey A. Mediterranean diet: higher fat but lower risk. J Fam Pract. 2013 Dec;62(12):745-8. PMID: 24340336; PMCID: PMC3891943.

Fitó M, Konstantinidou V. Nutritional Genomics and the Mediterranean Diet's Effects on Human Cardiovascular Health. Nutrients. 2016 Apr 13;8(4):218. doi: 10.3390/nu8040218. PMID: 27089360; PMCID: PMC4848687.

Boccardi V, Esposito A, Rizzo MR, Marfella R, Barbieri M, Paolisso G. Mediterranean diet, telomere maintenance and health status among elderly. PLoS One. 2013 Apr 30;8(4):e62781. doi: 10.1371/journal.pone.0062781. PMID: 23646142; PMCID: PMC3640022.

Visioli F, Galli C. The role of antioxidants in the Mediterranean diet. Lipids. 2001;36 Suppl:S49-52. doi: 10.1007/s11745-001-0682-z. PMID: 11837993.

https://www.usnews.com/info/blogs/press-room/articles/2022-01-04/u-s-news-reveals-best-diet-rankings-for-2022

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

15 Ways to Extend Human Life: Tips from Scientists and Experts

scott@skywax.com (Scott Lucas) — Fri, 08 Jul 2022 20:35:51 GMT

15 Ways to Extend Human Life: Tips from Scientists and Experts

We all desire to live a long and happy life, but it might sometimes appear that we're losing the battle. Luckily, scientists and experts have been working hard to find ways to extend human life, and they've made some amazing discoveries! In this blog post, we will discuss 15 of the best tips for extending human life. So whether you're looking for ways to improve your health or just trying to stay ahead of the curve, you'll want to read on!

Extending lifespan!

According to scientists and experts, here are 15 ways to extend human life by 33 percent:

Eat less. This may seem like an obvious one, but it's worth repeating. Eating less food can help you live longer! Calorie restriction has been shown to improve health and extend lifespan in a variety of species, including primates. So if you're looking to live a long and healthy life, cut back on the calories!

Exercise more. Exercise is another great way to improve your health and extend your lifespan. Numerous studies have shown that regular exercise can help you live longer and better. So get out there and start moving!

Get enough sleep. Sleep is important for health and longevity. Numerous studies have linked sleep deprivation with shorter lifespans. So make sure you're getting enough shut-eye!

Reduce stress. Stress can take a toll on your health, so it's important to find ways to reduce it in your life. Meditation, yoga, and other relaxation techniques can help you calm down and reduce stress.

Don't smoke. Smoking is one of the worst things you can do for your health. If you smoke, quit! It's never too late to improve your health and extend your life.

Limit alcohol consumption. Alcohol can be damaging to your health, so it's important to consume it in moderation. If you drink alcohol, limit yourself to one or two drinks per day.

Maintain a healthy weight. Being overweight or obese can shorten your lifespan, so it's important to maintain a healthy weight. Eat a healthy diet and exercise regularly to reach and maintain a healthy weight.

Get regular checkups. Regular medical checkups can help you catch health problems early when they're easier to treat. So be sure to see your doctor for regular checkups!

Live a healthy lifestyle. The better you take care of yourself, the longer you'll live. So make healthy choices and live a healthy lifestyle!

Avoid eating after dark. This tip comes from Dr. Satchin Panda, an expert on the circadian rhythm and its effects on our health. According to Dr. Panda, "The body is not designed to digest food at night." By avoiding nighttime eating, you can give your body a break and potentially increase your lifespan.

Another approach to adding years to your life is to concentrate on good dietary choices. This means eating lots of fruits, veggies, and whole grains while avoiding processed foods. Consuming a nutritious diet like the Mediterranean diet has been linked with a decreased risk of chronic diseases such as heart disease, diabetes, and cancer – all of which can extend your life.

Start your day with a nutritious shake packed with vitamins, minerals, and antioxidants. It will help you establish your hormones for the day as well as give a boost to your metabolism. Many people enjoy Metagenics' Ultra Meal daily support, which is a Practioner -Grade nutritional drink mix made up of macronutrients (carbohydrates, protein, and fats), phytonutrients, and essential vitamins and minerals. https://mmichael.metagenics.com/item/bundg0vy0ixs/ultrameal-daily-support/1-practitioner.html

Drinking green tea or fermented black tea can also help promote longevity. These teas are full of catechins which are antioxidants that can protect your cells from damage and help to reduce inflammation.

Detoxing the body is an excellent way to improve longevity by allowing the body to rid itself of toxins and waste that can damage cells. Two of the most popular Practitioner-Grade detox regimens are 10 days and 28 days, by Metagenics.

Using oxygen chamber therapy. This therapy involves breathing in pure oxygen in a chamber with slightly elevated pressure. Oxygen chamber therapy has been shown to improve cognitive function and reduce inflammation, both of which are important for healthy aging.

Conclusion

So, if you want to live a long and healthy life, consider following these tips from experts. By making small changes in your lifestyle, you could see big results in the form of a longer lifespan.

If you enjoyed this blog post, be sure to share it with your friends! And don't forget to subscribe to our blog for more great content like this. Thanks for reading!

If you're looking for information on how to improve your lifespan and turn on and off your genes, check out my new book " Understanding Genomics ; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers."

This book is a must-read if you want to learn how to control your genetic destiny! Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Dr. Marios Michael, DC, CNS, cFMP, 06/2022, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers, 1st edition, Austin, Bookbaby.

Davis DR, Epp MD, Riordan HD. Changes in USDA food composition data for 43 garden crops, 1950 to 1999. J Am Coll Nutr. 2004 Dec;23(6):669-82. doi: 10.1080/07315724.2004.10719409. PMID: 15637215. Jun;18(3):14-18. PMID: 32549804; PMCID: PMC7217393.

Darmon N, Darmon M, Maillot M, Drewnowski A. A nutrient density standard for vegetables and fruits: nutrients per calorie and nutrients per unit cost. J Am Diet Assoc. 2005 Dec;105(12):1881-7. doi: 10.1016/j.jada.2005.09.005. PMID: 16321593.

Di Renzo L, Gualtieri P, Romano L, Marrone G, Noce A, Pujia A, Perrone MA, Aiello V, Colica C, De Lorenzo A. Role of Personalized Nutrition in Chronic-Degenerative Diseases. Nutrients. 2019 Jul 24;11(8):1707. doi: 10.3390/nu11081707. PMID: 31344895; PMCID: PMC6723746.

Ramos-Lopez O, Milagro FI, Allayee H, Chmurzynska A, Choi MS, Curi R, De Caterina R, Ferguson LR, Goni L, Kang JX, Kohlmeier M, Marti A, Moreno LA, Pérusse L, Prasad C, Qi L, Reifen R, Riezu-Boj JI, San-Cristobal R, Santos JL, Martínez JA. Guide for Current Nutrigenetic, Nutrigenomic, and Nutriepigenetic Approaches for Precision Nutrition Involving the Prevention and Management of Chronic Diseases Associated with Obesity. J Nutrigenet Nutrigenomics. 2017;10(1-2):43-62. doi: 10.1159/000477729. Epub 2017 Jul 8. PMID: 28689206.

Bailey RL, West KP Jr, Black RE. The epidemiology of global micronutrient deficiencies. Ann Nutr Metab. 2015;66 Suppl 2:22-33. doi: 10.1159/000371618. Epub 2015 Jun 2. PMID: 26045325.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Dangers of Poor Nutrition: How It Can Impact Your Life

scott@skywax.com (Scott Lucas) — Thu, 07 Jul 2022 19:23:12 GMT

The Dangers of Poor Nutrition: How It Can Impact Your Life

Did you know that poor nutrition can impact every aspect of your life? It can affect your physical health, mental health, and even your career. In this blog post, we will discuss the dangers of poor nutrition and how it can affect your life. We will also provide tips for improving your nutrition and living a healthier lifestyle.

Lack of Nutrients

If you are not getting the nutrients your body needs, it can lead to serious health problems. Poor nutrition can weaken your immune system, making you more susceptible to illness and disease. It can also cause weight gain, high blood pressure, and high cholesterol. Poor nutrition can even impact your mental health, causing depression, anxiety, and mood swings.

Poor Nutrition and your DNA

Did you know that poor nutrition can impact your DNA? Studies have shown that a diet lacking in certain nutrients can change the structure of your DNA. This can lead to a number of health problems, including an increased risk for chronic diseases. So, if you're not getting enough of the right nutrients, it could be time to make some changes to your diet.

Poor nutrition can also affect your career. If you are not getting the nutrients your body needs, it can impact your productivity and performance at work. People who do not get enough nutrients in their diets tend to be ill more frequently.

Apples to apples!

One apple in the 1960s had the same nutritional value as four of today's apples. Today's beef and chicken have more saturated unhealthy fat, calories, and bad cholesterol than those from 40 years ago. The list goes on.

In December 2004, the Journal of the American College of Nutrition published landmark research by Don Davis and his team from the Department of Chemistry and Biochemistry at the University of Texas (UT), Austin. They reviewed USDA nutritional data for 43 different vegetables and fruits going back to 1950, revealing “reliable declines” in the amount of protein, calcium, phosphorus, iron, riboflavin (vitamin B2) and vitamin C over the past half-century. The growing prevalence of agricultural practices that aim to improve non-nutritional characteristics (yield, size, growth rate, pest resistance) rather than nutritional value is partly to blame, according to the researchers.

What does this mean for our health?

It means that we are consuming more empty calories than ever before. We are also lacking in essential vitamins and minerals that are vital to our health. This can lead to a whole host of problems including obesity, diabetes, heart disease, and even cancer.

So what can we do to combat this problem?

For starters, we need to be aware of the foods we are eating and their nutritional value. Make sure you are eating a variety of healthy foods. This includes fruits, vegetables, whole grains, lean protein, and low-fat dairy. Second, limit your intake of processed foods, sugary drinks, and unhealthy fats. Third, make sure you are getting enough exercise. Exercise not only helps improve your physical health but can also improve your mental health. Finally, make sure you are getting enough sleep. Sleep is essential for good health and well-being.

Supplements to help combat poor nutrition

There are a few key supplements that can help combat poor nutrition. These include vitamins A, C, and E, iron, iodine, folate, as well as the mineral zinc. Vitamin A is important for vision and immune function, while vitamin C is crucial for wound healing and tissue repair. Vitamin E is a powerful antioxidant that helps protect cells from damage. Iron is needed for hemoglobin, which carries oxygen in the blood. A lack of iron can lead to anemia, which can make you tired and weak. Iodide is needed for the production of thyroid hormone. Folate is needed for the production of red blood cells and zinc plays a role in cell growth and development. Taking a daily multivitamin can help ensure you are getting all the nutrients you need. https://mmichael.metagenics.com/item/bund3khsuhfb/multivitamin/1-practitioner.html can help ensure that you're getting enough of these essential nutrients.

By following these tips, you can improve your nutrition and live a healthier, happier life. However, if you think you may be suffering from poor nutrition, it is important to see a doctor, a registered dietitian, or a nutritionist to get a complete evaluation. They can help you develop a plan to improve your nutrition and achieve optimal health..

If you'd like to discover more about nutrition and how to eat for your DNA and genes, as well as how to activate and deactivate your genes, check out chapter # 5 of my new book " Understanding Genomics ; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers."

This book is a must-read if you want to learn how to control your genetic destiny! Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Dr. Marios Michael, DC, CNS, cFMP, 06/2022, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers, 1st edition, Austin, Bookbaby.

Davis DR, Epp MD, Riordan HD. Changes in USDA food composition data for 43 garden crops, 1950 to 1999. J Am Coll Nutr. 2004 Dec;23(6):669-82. doi: 10.1080/07315724.2004.10719409. PMID: 15637215. Jun;18(3):14-18. PMID: 32549804; PMCID: PMC7217393.

Darmon N, Darmon M, Maillot M, Drewnowski A. A nutrient density standard for vegetables and fruits: nutrients per calorie and nutrients per unit cost. J Am Diet Assoc. 2005 Dec;105(12):1881-7. doi: 10.1016/j.jada.2005.09.005. PMID: 16321593.

Di Renzo L, Gualtieri P, Romano L, Marrone G, Noce A, Pujia A, Perrone MA, Aiello V, Colica C, De Lorenzo A. Role of Personalized Nutrition in Chronic-Degenerative Diseases. Nutrients. 2019 Jul 24;11(8):1707. doi: 10.3390/nu11081707. PMID: 31344895; PMCID: PMC6723746.

Ramos-Lopez O, Milagro FI, Allayee H, Chmurzynska A, Choi MS, Curi R, De Caterina R, Ferguson LR, Goni L, Kang JX, Kohlmeier M, Marti A, Moreno LA, Pérusse L, Prasad C, Qi L, Reifen R, Riezu-Boj JI, San-Cristobal R, Santos JL, Martínez JA. Guide for Current Nutrigenetic, Nutrigenomic, and Nutriepigenetic Approaches for Precision Nutrition Involving the Prevention and Management of Chronic Diseases Associated with Obesity. J Nutrigenet Nutrigenomics. 2017;10(1-2):43-62. doi: 10.1159/000477729. Epub 2017 Jul 8. PMID: 28689206.

Bailey RL, West KP Jr, Black RE. The epidemiology of global micronutrient deficiencies. Ann Nutr Metab. 2015;66 Suppl 2:22-33. doi: 10.1159/000371618. Epub 2015 Jun 2. PMID: 26045325.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

A Guide to Functional Medicine: Everything You Need to Know

scott@skywax.com (Scott Lucas) — Tue, 05 Jul 2022 18:48:07 GMT

A Guide to Functional Medicine:

Everything You Need to Know

If you're like most people, you've probably never heard of Functional Medicine. But that's about to change. Functional Medicine is a new and growing field in the medical world, and it's gaining popularity fast. So what is Functional Medicine? And what can it do for you? In this blog post, we will answer all of your questions about Functional Medicine! We'll explain what it is, how it works, and why more and more people are choosing to pursue this type of treatment. So if you're curious about Functional Medicine, read on! You won't regret it.

What is Functional Medicine?

Functional Medicine is a branch of medicine that focuses on preventing and treating diseases by addressing the underlying causes. It takes a systems-oriented approach and looks at the whole person, not just symptoms. This approach to medicine is constantly evolving, as new discoveries are made about the human body and how it works.

This means that instead of simply treating disease, Functional Medicine Practitioners look at all of the factors that may be contributing to it. This could include things like diet, lifestyle, stress levels, and environment, as well as their genetic makeup. By taking a holistic approach, Functional Medicine Practitioners can develop a personalized treatment plan for each patient.

How does functional medicine work?

Functional Medicine Practitioners use a variety of techniques to treat their patients. Conventional labs, Functional Medicine diagnostic testing, and Genomics are often used to identify imbalances in the body. Once these imbalances are identified, Practitioners can develop a treatment plan to correct them. This might involve making dietary changes, taking supplements, or making lifestyle changes.

It is a personalized approach to healthcare that takes into account a person's unique circumstances and needs. It is based on the belief that each person is biochemically unique, and that no two people are exactly alike. The goal of holistic medicine is to understand that all parts of a person's life are linked and that each one may have an impact on the others.

What are the benefits of Functional Medicine?

According to the CDC, 6 out of every 10 people in the United States are affected by a chronic illness. Four out of ten adults in the US have two or more chronic conditions. These include heart disease, stroke, cancer, diabetes, Alzheimer's disease, chronic kidney disease, chronic lung disease and arthritis. With the increase in chronic conditions and illnesses, people are searching for methods to improve their health and immunity. Functional Medicine can help people to achieve this.

What are the principles of Functional Medicine?

The principles of Functional Medicine include:

Identifying and addressing the root causes of disease
Treating the whole person, not just symptoms
Using a systems-oriented approach
Personalized care based on each person's unique needs

Why more and more people are choosing Functional Medicine?

There are a few reasons why Functional Medicine is gaining popularity. First of all, it's effective. By taking a holistic approach, Functional Medicine Practitioners can treat the whole person, not just their symptoms. This often leads to better long-term results. Second, it addresses the demands of those who suffer from chronic diseases better than traditional medicine does. It can also help improve mental health and well-being. The integrative approach of Functional Medicine can also help to reduce stress levels and promote relaxation. Additionally, Functional Medicine is much less expensive than traditional medicine. And finally, more and more people are beginning to realize the importance of taking a proactive approach to their health and are looking for natural and alternative treatments that don't have the same side effects as traditional medications. When it comes to Functional Medicine, there is no one-size-fits-all approach.

Functional Medicine uses Practitioner-Grade supplements.

This means that the supplements are only available through a healthcare professional link to my store https://www.drmichaelswellness.com/store and not over the counter. The benefit of using Practitioner-Grade supplements is that they are held to a higher standard, ensuring their purity, potency, safety and efficacy.

Conclusion

If you're interested in learning more about Functional Medicine, be sure to speak with a healthcare professional who is knowledgeable in this area. https://www.drmichaelswellness.com . They can help you determine if it's the right approach for you and create a customized treatment plan.

If you'd like to learn more about Functional Medicine and how to utilize your DNA to your advantage, I highly recommend my new book, " Understanding Genomics ; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers ".

This book is a must-read if you want to learn how to control your genetic destiny! Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Dr. Marios Michael, DC, CNS, cFMP, 06/2022, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers, 1st edition, Austin, Bookbaby.
https://www.cdc.gov/chronicdisease/about/index.htm
Bland JS. What is Evidence-Based Functional Medicine in the 21st Century? Integr Med (Encinitas). 2019 Jun;18(3):14-18. PMID: 32549804; PMCID: PMC7217393.
https://www.ifm.org/functional-medicine/what-is-functional-medicine/
https://www.nccih.nih.gov/health/complementary-alternative-or-integrative-health-whats-in-a-name
https://www.functionalmedicineuniversity.com
Bland Jeffrey S. The Disease Delusion: Conquering the Causes of Chronic Illness for a Healthier, Longer, and Happier Life. New York: HarperWave, 2014.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

It is time to rethink our relationship with food

scott@skywax.com (Scott Lucas) — Fri, 01 Jul 2022 16:39:56 GMT

It is time to rethink our relationship with food

We all have our own personal relationship with food. Some people see food as a way to fuel their bodies and meet their nutritional needs. Others see food as a source of comfort and pleasure. And still, others view food as an enemy, something that needs to be restricted and controlled. But what if we could rethink our relationship with food? What if we could approach eating from a new perspective? In this blog post, we will explore some of the ways that we can change our thinking about food and create healthier, more balanced eating habits.

Healthy or unhealthy, clean or junk!

One of the first things we need to do is to stop seeing food as good or bad. Too often, we categorize foods as being "healthy" or "unhealthy," "clean" or "junk." This way of thinking sets us up for a black-and-white mindset that can lead to restrictive eating habits and an unhealthy relationship with food. Instead of labeling foods, we should think about them in terms of how they make us feel. Some foods may give us energy and make us feel good, while others may leave us feeling sluggish and bloated. When we focus on how food makes us feel, we are more likely to make choices that are in line with our health goals.

Another way to rethink our relationship with food is to eat mindfully. This means being present and aware of what we are eating, without distractions like TV or our phones. When we eat mindfully, we are more likely to savor our food and appreciate the flavors and textures. We are also less likely to overeat because we are paying attention to our bodies' cues of hunger and fullness.

Chewing our meals 15-20 times each bite can help us eat more slowly and mindfully. This allows our bodies to register that we are eating.It can be helpful to put down our utensils between bites and to avoid drinking liquids with our meals so that we are forced to slow down.

Another way to rethink our relationship with food is to consider how it nourishes us. When we focus on the nutrients our food provides, rather than just its taste or calorie content, we can make more healthful choices.

Eating for our DNA

Eating for our DNA can also help us to make more nutritious choices. We all have different genetic makeups, which means that we may require different nutrients. Some people, for example, may require more iron than others or have different genetic pathways for metabolizing carbohydrates, proteins, and lipids. Knowing what our bodies need can help us to choose foods that will give us the most benefit. The Mediterranean Diet appears to be the most beneficial for most people's DNA.

Our relationship with food

Eating habits are personal preferences that develop over time. Some people prefer to eat three large meals per day, while others prefer to eat smaller meals more often. There is no "right" way to eat, and different people will have different eating habits.

Rethinking our relationship with food can be a challenge, but it is worth it. When we approach eating from a new perspective, we can develop healthier habits that will last a lifetime. When we approach eating from a place of mindfulness and nutrition, we are more likely to nourish our bodies in the way they deserve.

Finally, we need to remember that food is not the enemy. It is not something that we need to be feared, restrict, or avoid. Food is nourishment and enjoyment. It should be savored and appreciated. When we have a healthy relationship with food, we can enjoy all the wonderful things it has to offer.

If you're interested in learning more about our connection with food and how it interacts with your DNA and genes, as well as how to make Your genes work for Your benefit, check out my new book " Understanding Genomics ; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers.

This book is a must-read if you want to learn how to control your genetic destiny! Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Dr. Marios Michael, DC, CNS, cFMP, 06/2022, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers, 1st edition, Austin, Bookbaby

Farooq M, Sazonov E. Automatic Measurement of Chew Count and Chewing Rate during Food Intake. Electronics (Basel). 2016;5(4):62. doi: 10.3390/electronics5040062. Epub 2016 Sep 23. PMID: 29082036; PMCID: PMC5656270

Jezewska-Zychowicz M, Plichta M, Drywień ME, Hamulka J. Food Neophobia among Adults: Differences in Dietary Patterns, Food Choice Motives, and Food Labels Reading in Poles. Nutrients. 2021 May 10;13(5):1590. doi: 10.3390/nu13051590. PMID: 34068662; PMCID: PMC8151374

Abdella HM, El Farssi HO, Broom DR, Hadden DA, Dalton CF. Eating Behaviours and Food Cravings; Influence of Age, Sex, BMI and FTO Genotype. Nutrients. 2019 Feb 12;11(2):377. doi: 10.3390/nu11020377. PMID: 30759834; PMCID: PMC6412354

Mazurek-Kusiak AK, Kobyłka A, Korcz N, Sosnowska M. Analysis of Eating Habits and Body Composition of Young Adult Poles. Nutrients. 2021 Nov 15;13(11):4083. doi: 10.3390/nu13114083. PMID: 34836335; PMCID: PMC8624486

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Top 11 Benefits of Rotating Your Probiotics

scott@skywax.com (Scott Lucas) — Thu, 30 Jun 2022 20:00:33 GMT

The Top 11 Benefits of Rotating Your Probiotics

Did you know that probiotics need to be rotated to receive the full benefits? It's true! In this blog post, we will discuss the top eleven benefits of rotating your probiotics. Probiotics are essential for gut health, and if you don't rotate them, you could be missing out on some major benefits. Keep reading to learn more about why probiotic rotation is so important!

Probiotics 101

Probiotics are live bacteria that are beneficial for gut health. They can be found in fermented foods like yogurt and sauerkraut, or they can be taken as a supplement. Probiotics are important for gut health because they help to restore the balance of good and bad bacteria in the gut. When the balance of good and bad bacteria is off, it can lead to digestive issues like diarrhea, constipation, and bloating. Probiotics can also help to boost the immune system and improve overall health.

Mechanism of action

Ideally, a probiotic should pass through the stomach and small intestines to reach the large intestine. This is where they do their work, by interacting with gut microbiota. The problem is that the stomach produces hydrochloric acid to digest food and this also kills most of the probiotics. So we need to take large numbers of them every day for there to be any effect at all.

Once probiotics reach the large intestine they produce short-chain fatty acids from dietary fiber. This provides us with energy. They also help to keep the colon healthy by maintaining a beneficial relatively acidic environment with a pH level of 6. The production of acid by the large intestine is thought to have anti-inflammatory advantages. Finally, Probiotics must be able to adhere to the gut and repopulate, preventing germs and pathogens from attaching to the colon.

Different types of probiotics

There are many different types of probiotics, such as Lactobacillus, Bifidobacterium, Saccharomyces, Streptococcus, Enterococcus, Escherichia, and Bacillus and each one has its own set of benefits. That's why it's important to rotate your probiotics. By taking a variety of different probiotics, you will receive the full benefits that each one has to offer. Probiotic rotation can also help to prevent your body from becoming immune to the bacteria. If you take the same probiotic every day, your body may eventually become used to it and it will no longer be as effective.

Benefits of Probiotic Rotation

So, what are the benefits of rotating your probiotics? Here are the top eleven:

Improved Gut Health : Probiotics help to restore the balance of good and bad bacteria in the gut. When this balance is off, it can lead to digestive issues like diarrhea, constipation, and bloating. By taking a variety of different probiotics, you can help to keep your gut healthy.

Boosted Immune System : Probiotics can help to boost the immune system, which can help you to stay healthy and avoid getting sick.

Improved Overall Health : Probiotics have been shown to improve overall health, including blood pressure, cholesterol levels, and inflammation.

Reduced Risk of Allergies : Probiotics may help to reduce the risk of developing allergies.

Improved Digestion : Probiotics can help to improve digestion and make it easier for your body to absorb nutrients.

Reduced Risk of Infections : Probiotics may help to reduce the risk of developing infections, such as yeast infections and urinary tract infections.

Prevention of Antibiotic Resistance : Probiotics can help to prevent antibiotic resistance, which is when bacteria become resistant to antibiotics. This is a serious problem that can lead to difficult-to-treat infections.

Probiotics also help with the production of vitamins , including biotin, folic acid, vitamin K, and some B-vitamins.

Lactose intolerance is caused by a lack of the enzyme lactase, which breaks down lactose, the sugar in milk. Probiotics can help because they produce lactase themselves.

Probiotics have been found to benefit persons with Inflammatory Bowel Disease (IBD), a chronic inflammatory condition that includes Ulcerative Colitis and Crohn's disease, as well as Irritable Bowel Syndrome (IBS) and Atopic

Dermatitis, the most common form of eczema.

By rotating your probiotics , you’re exposing your gut to different strains of bacteria, which can help to increase the diversity of your gut flora and fight obesity.

How to test Your Gut bacteria

GI Effects from Genova Diagnostics is a comprehensive Functional Medicine assessment test that covers the entire gut health picture, including microbiota quantity and balance (gut microbes). PCR (DNA amplification tool), culture, and microscopic analysis are used to ensure that any and all relevant organisms are detected. Biomarkers are grouped and scored in 5 key areas relating to gastrointestinal (GI) function:

Maldigestion
Inflammation
Dysbiosis
Metabolite Imbalance
Infection

The importance of quality probiotic supplement

So as you can see, there are many benefits to taking a probiotic supplement and rotating it to get the most benefit from it. If you are not currently taking a probiotic, I highly recommend that you start, and if you are, consider changing the brand or type that you take regularly. it is recommended that you rotate your brands and strains every few months.

But remember, not all probiotics are created equal. Be sure to choose a high-quality Practioner -Grade supplement and rotate it to get the most benefit. https://us.fullscript.com/welcome/mmichael

The following are some of the suggested supplements:

Metagenics ; Ultra Flora

Orthomolecular ; Probiotic 225

Pure Encapsulations ; Probiotic 50B Acid-resistant capsules with pH release

Thorne ; FloraMend Prime Probiotic

If you'd like to discover more about probiotics and their interaction with your DNA and genes, as well as how to make Your genes work for You, check out chapter #6 of my new book "Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers."

This book is a must-read if you want to learn how to control your genetic destiny! Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Dr. Marios Michael, DC, CNS, cFMP, 06/2022, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers, 1st edition, Austin, Bookbaby

Michael J. Glade, Ph.D., FACN, CNS, Certification Board for Nutrition. Specialists, 2002

https://ods.od.nih.gov/factsheets/Probiotics-HealthProfessional/

Blaabjerg S, Artzi DM, Aabenhus R. Probiotics for the prevention of antibiotic-associated diarrhea in outpatients-a systematic review and meta-analysis. Antibiotics (Basel) 2017;6 .

Huang R, Ning H, Shen M, Li J, Zhang J, Chen X. Probiotics for the treatment of atopic dermatitis in children: a systematic review and meta-analysis of randomized controlled trials. Front Cell Infect Microbiol 2017;7:392

Didari T, Mozaffari S, Nikfar S, Abdollahi M. Effectiveness of probiotics in irritable bowel syndrome: Updated systematic review with meta-analysis. World J Gastroenterol 2015;21:3072-84.

Lorenzo-Zuniga V, Llop E, Suarez C, Alvarez B, Abreu L, Espadaler J, et al. I.31, a new combination of probiotics, improves irritable bowel syndrome-related quality of life. World J Gastroenterol 2014;20:8709-16.

https://www.gdx.net/product/gi-effects-comprehensive-stool-test

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Many Benefits of Garlic: A Superfood for Your Health

scott@skywax.com (Scott Lucas) — Tue, 28 Jun 2022 17:42:05 GMT

The Many Benefits of Garlic:

A Superfood for Your Health

Many of my patients want to know if a one-pill-per-day cure is feasible, as well as why they should take it. The answer may surprise you, just as it does them.

Just a single pill each day!

If you have to take a single pill every day, garlic with an enteric coating would be the way to go. Garlic is a wonderful superfood that has long been used for medicinal purposes. It has been utilized therapeutically for millennia, dating back to ancient Greece, Rome, and Egypt. During World War II, it was even used to prevent gangrene. In this blog post, we will discuss the many benefits of garlic and how you can add it to your diet!

Chronic conditions

Benefits

Garlic is a fantastic method to achieve just that! Not only does garlic have a long list of health benefits, but it is also very adaptable and simple to incorporate into your diet. Garlic has been found in recent studies to aid with the following:

Garlic extract is a natural anti-oxidant that increases the DNA repair process. It also aids in the maintenance of healthy, strong DNA.
Garlic can help reduce the risk of heart disease.
Garlic's sulfur chemicals are thought to aid in the prevention of plaque accumulation in the arteries.
Garlic can also help lower blood pressure and cholesterol levels
Garlic can help boost the immune system.
Garlic can help improve cognitive function.
Garlic can help protect against Alzheimer’s disease and dementia.
Garlic can help reduce inflammation throughout the body.
Garlic can help improve respiratory health.
Garlic can help detoxify the body.
Garlic can help increase the production of stomach acid, which helps to break down food and prevent indigestion.
Garlic can help reduce the risk of cancer. Several studies have shown that garlic can help reduce the risk of various types of cancer, including stomach, colon, and ovarian cancer. The compounds in garlic are thought to inhibit the growth of cancer cells.

Be part of the Allium family!

Garlic is a member of the Allium family, which also includes onions, leeks, and chives. Allicin, a compound found in garlic, is responsible for many of its health benefits. This compound has antibacterial, antiviral, and anti-fungal properties. Garlic also contains other important nutrients, including vitamins C and B, manganese, selenium, and fiber.

There are many ways to incorporate garlic into your diet. You can add it to your cooking, or take supplements if you don’t like the taste. Garlic supplements are available in capsules, tablets, and liquids. If you're using garlic for therapeutic or other purposes and have unaddressed symptoms or underlying diseases, it's important to consult with your doctor before taking garlic supplements.

Risks

Garlic risks include:

Allergic reactions in some people
Bad breath
Body odor
Heartburn
Nausea and vomiting
Rashes
Stomach upset
Some medications, such as birth control pills, and blood thinners can interact with it.

Raw garlic vs aged

There are two types of garlic: raw garlic and aged garlic. Raw garlic is the kind you’re probably most familiar with. It’s the kind you find in the produce section of your grocery store. Aged garlic is made by fermenting raw garlic, and it has a more mellow flavor.

Some people believe that aged garlic is more effective than raw garlic, but there is no scientific evidence to support this claim. Both types of garlic are healthy and can be used in cooked dishes or taken as a supplement.

If you’re looking for the health benefits of garlic, you can’t go wrong with either type. Just make sure to choose a high-quality product from a reputable source.

Practitioner - Grade Garlic Supplements

When it comes to garlic supplements, choose one with a good quality and high allicin levels (https://mmichael.metagenics.com/item/bundypy9onkm/garlic/1-practitioner.html) that has an enteric coating designed to dissolve in the intestine, not the mouth or stomach, so you can enjoy all of garlic's benefits without getting garlic breath or stomach discomfort.

Conclusion

When it comes to garlic, there are many benefits that this powerful little superfood has to offer. From helping to boost your immune system, to aiding in digestion and even acting as a natural antibiotic, garlic is truly a powerhouse when it comes to keeping your body healthy.

No matter how you choose to eat it, garlic is a great addition to any diet. So next time you are looking for a little something extra to boost your health, reach for the garlic! With so many benefits, it is no wonder that this superfood is becoming more and more popular.

If you'd like to learn more about garlic and other essential nutrients, as well as how to turn your genes on and off, check out chapter #9 of my new book, "Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers.

This book is a must-read if you want to learn how to control your genetic destiny! Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Dr. Marios Michael, DC, CNS, cFMP, 06/2022, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers, 1st edition, Austin, Bookbaby

https://www.cdc.gov/chronicdisease/about/index.htm

Mathew B, Biju R. Neuroprotective effects of garlic a review. Libyan J Med. 2008;3(1):23-33. Published 2008 Mar 1. doi:10.4176/071110

https://lpi.oregonstate.edu/mic/food-beverages/garlic

Carmia Borek, Garlic Reduces Dementia and Heart-Disease Risk, The Journal of Nutrition, VolumeRana, S., Pal, R., Vaiphei, K., Sharma, S., & Ola, R. (2011)

Shaikh K, Kinninger A, Cherukuri L, Birudaraju D, Nakanishi R, Almeida S, Jayawardena E, Shekar C, Flores F, Hamal S, Sheikh MS, Johanis A, Cu B, Budoff MJ. Aged garlic extract reduces low attenuation plaque in coronary arteries of patients with diabetes: A randomized, double-blind, placebo-controlled study. Exp Ther Med. 2020 Feb;19(2):1457-1461. doi: 10.3892/etm.2019.8371. Epub 2019 Dec 27. PMID: 32010322; PMCID: PMC6966158

Garlic in health and disease. Nutrition Research Reviews, 24(1), 60-71. doi:10.1017/S0954422410000338136, Issue 3, March 2006, Pages 810S–812S, https://doi.org/10.1093/jn/136.3.810S

Please Note: This blog post is for informational purposes only and does not constitute medical advice nor does it establish a practitioner-patient relationship. If you have any concerns about your health, please consult with a qualified healthcare professional.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Truth About Intermittent Fasting: Benefits, Risks, and More

scott@skywax.com (Scott Lucas) — Mon, 27 Jun 2022 15:40:18 GMT

The Truth About Intermittent Fasting: Benefits, Risks, and More

Intermittent fasting is becoming increasingly popular. But what is it? And more importantly, is it good for you? In this blog post, we will discuss intermittent fasting in detail. We will look at the benefits, risks, and different types of intermittent fasting. Plus, we will explore the scientific evidence behind intermittent fasting and its potential effects on longevity.

Intermittent fasting 101

So, what is intermittent fasting? Intermittent fasting is a type of diet where you alternate between fasts and eating periods. It might mean going without food for 16 hours and then eating all of your meals in an eight-hour period. Alternatively, it might imply only consuming one meal a day.

Types of intermittent fasting

There are several different types of intermittent fasting, including:

- The 16/eight method: Also called the Leangains protocol, this involves fasting for 16 hours and eating only during an eight-hour window.

- Eat-stop-eat: This intermittent fasting approach lasts for 24 hours at a time, once or twice per week. For example, you might skip dinner one night and have supper the next.

- The five-two diet: With this intermittent fasting plan, you eat normally five days a week and restrict your calories to 500–600 on two days.

- Spontaneous meal skipping: This is when you skip meals occasionally, without planning ahead of time.

Benefits

There are many potential benefits of intermittent fasting. These include weight loss, improved insulin sensitivity, reduced inflammation, increase lifespan, and stimulating autophagy.

Intermittent fasting has been shown to trigger autophagy. The process of autophagy is how your body breaks down and recycles worn or dysfunctional cells. Our own recycling process. This helps to keep your cells healthy while also slowing the aging process. Intermittent fasting has also been linked to higher levels of human growth hormone (HGH), which is associated with muscle mass gain, fat loss, and improved bone density.

Intermittent fasting may also help to protect against Alzheimer’s disease and other age-related cognitive declines. This is because intermittent fasting has been shown to improve brain function and reduce inflammation.

Intermittent fasting has also been shown to improve heart health by reducing blood pressure, bad cholesterol, and triglyceride levels. Plus, it can help to lower insulin levels, which is a risk factor for heart disease.

Risks

So, what are the risks of intermittent fasting? As with any diet or lifestyle change, there are always potential risks. These include dehydration, hunger, low blood sugar, and irritability.

It’s also important to note that intermittent fasting is not suitable for everyone. If you have any underlying health conditions, or if you are pregnant or breastfeeding, it’s best to speak to a doctor before starting intermittent fasting.

Conclusion

Intermittent fasting is a popular diet trend with many potential health benefits. However, it’s not suitable for everyone and there are some risks to be aware of. If you’re thinking of trying intermittent fasting, speak to your doctor first.

Will you try intermittent fasting? What concerns you the most about this type of diet? Let us know in the comments below. Thanks for reading!

If you’re interested in learning more about intermittent fasting, and how to turn your genes on and off, check out chapter #9 of my new book, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers.

This book is a must-read if you want to learn how to control your genetic destiny! Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Dr. Marios Michael, DC, CNS, cFMP, 06/2022, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers, 1st edition, Austin, Bookbaby.

Molina-Serrano D, Kyriakou D, Kirmizis A. Histone Modifications as an Intersection Between Diet and Longevity. Front Genet. 2019;10:192. Published 2019 Mar 12. doi:10.3389/fgene.2019.00192. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422915/

Vitale G, Pellegrino G, Vollery M, Hofland LJ. Role of IGF-1 System in the Modulation of Longevity: Controversies and New Insights From a Centenarians’ Perspective. Front Endocrinol (Lausanne). 2019;10:27. Published 2019 Feb 1. doi:10.3389/ fendo.2019.00027. https://www.ncbi.nlm.nih.gov/pmc/articles/ PMC6367275/
Swan, Brendan. PhD., “What Is Autophagy? Definition, Benefits, Ways to Increase It.” Selfhacked, September 20, 2021.

Pyo JO, Yoo SM, Ahn HH, Nah J, Hong SH, Kam TI, Jung S, Jung YK. Overexpression of Atg5 in mice activates autophagy and extends lifespan. Nat Commun. 2013;4:2300. doi: 10.1038/ncomms3300. PMID: 23939249; PMCID: PMC3753544.

Gunnars, Kris BSc. “Intermittent Fasting 101 – The Ultimate Beginner’s Guide.” healthline, April 20, 2020. https://www. healthline.com/nutrition/intermittent-fasting-guide#methods

Petrow, Steven. “Intermittent fasting works for many – not only for weight loss but also for heart health.” The Washington Post, June 13, 2020. https://www.washingtonpost.com/health/ intermittent-fasting-works-for-many--not-only-for-weight-loss- but-also-for-heart-health/2020/06/12/11420c1c-a4d5-11ea-b619- 3f9133bbb482_story.html

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

10 Systems That Decline With Aging And What You Can Do About It

scott@skywax.com (Scott Lucas) — Fri, 24 Jun 2022 20:49:50 GMT

10 Systems That Decline With Aging And What You Can Do About It

As we age, our bodies slowly start to decline. This is a natural process, but it can be frustrating for those who are affected by it. Luckily, there are ways to combat the effects of aging. In this blog post, we will discuss 10 systems that tend to decline with age and what you can do about it!

There are a variety of systems in our bodies that can deteriorate as we age. The following are ten examples of the most prevalent ones:

• Cardiovascular system : The cardiovascular system includes the heart and blood vessels. With aging, the heart muscle can become weaker and less efficient at pumping blood. This can lead to high blood pressure, heart disease, and stroke.

• Respiratory system : The respiratory system includes the lungs and airways. With aging, the lungs can become less efficient at exchanging oxygen and carbon dioxide. This can lead to shortness of breath, difficulty breathing, and lung disease.

• Gastrointestinal system : The gastrointestinal system includes the stomach and intestines. With aging, the digestive muscles can weaken and the lining of the stomach and intestines can thin. This can lead to indigestion, constipation, and diarrhea.

• Nervous system : The nervous system includes the brain and nerves. With aging, the brain can shrink and lose connections between nerve cells. This can lead to memory loss, confusion, and difficulty with thinking and decision-making.

• Endocrine system : The endocrine system includes the glands that produce hormones. With aging, the glands can become less efficient at producing hormones. This can lead to hormone imbalances, which can cause a variety of problems like fatigue, weight gain, and mood swings.

• Immune system : The immune system includes the cells and organs that protect the body from infection and disease. With aging, the immune system can become less efficient at fighting off infection and disease. This can lead to a higher risk of contracting illnesses like the flu or pneumonia.

• The muscular and skeletal systems : The bones, muscles, and joints are all parts of the musculoskeletal system. The bones might grow weaker and more fragile as we age. Muscles can atrophy (wasting away) and lose strength, as well as stiffness and pain in the joints. Osteoporosis, arthritis, and frailty are all problems that can arise from age-related decline in the musculoskeletal system.

• The skin : The skin is the largest organ in the body. With aging, the skin becomes thinner, drier, and less elastic. This can lead to wrinkles, sagging skin, and an increased risk of injury.

• Reproductive system : The reproductive system includes the organs that produce eggs or sperm. With aging, the reproductive organs can decline in function. This can lead to infertility and a decreased sex drive.

• Urinary system : The urinary system includes the kidneys, bladder, and urethra. With aging, the kidneys can become less efficient at filtering waste from the blood. The bladder can become less elastic and more prone to leaking. The urethra can narrow and become blocked more easily. This can lead to kidney disease, urinary incontinence, and urinary tract infections.

The optimal strategy to age healthily and gracefully while avoiding chronic degenerative illnesses is to preserve our DNA and cell health. Ways to protect our DNA include eating a healthy diet such as the Meditteranean diet, avoiding toxins, and detoxing therapy exercising regularly, and getting enough sleep.

Another alternative is to take certain nutraceuticals that have been shown to aid in DNA protection. Practioner - Grade supplements designed for each system might be quite beneficial .

If you are concerned about any changes you are experiencing, please consult with your doctor. They can help you determine if the changes are normal for aging or if there is something more serious going on. With prevention, DNA protection, early detection, and treatment, many of the problems associated with aging can be prevented or delayed.

If you’re interested in learning more about supplements and how to make your DNA work for you, check out chapter # 6 of my new book, Understanding Genomics ; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers.

As the name implies, this book will teach you how to unlock your genetic superpowers with nutrition, Practitioner-Grade supplements, and lifestyle.

For those who want to live a longer and healthier life, this book is a must-read! Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Dr. Marios Michael, DC, CNS, cFMP, 06/2022, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers, 1st edition, Austin, Bookbaby.

Davalli P, Mitic T, Caporali A, Lauriola A, D'Arca D. ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases. Oxid Med Cell Longev. 2016;2016:3565127. doi: 10.1155/2016/3565127. Epub 2016 May 10. PMID: 27247702; PMCID: PMC4877482.Cornelissen G, Otsuka K.

Chronobiology of Aging: A Mini-Review. Gerontology. 2017;63(2):118-128. doi: 10.1159/000450945. Epub 2016 Oct 22. PMID: 27771728.Aging and the Microbiome: What Happens When You Get Older?” Atlas Blog, October 31, 2020. https://atlasbiomed.com/blog/ageing-and-the-gut-microbiome/

Rogina B., Reenan R.A., Nilsen S.P., Helfand S.L. Extended Life-Span Conferred by Cotransporter Gene Mutations in Drosophila. Science. 2000;290:2137–2140. doi: 10.1126/science.290.5499.2137. - DOI - PubMed

Ferrucci L., Fabbri E. Inflammageing: Chronic inflammation in ageing, cardiovascular disease, and frailty. Nat. Rev. Cardiol. 2018;15:505–522. doi: 10.1038/s41569-018-0064-2. - DOI - PMC

PubMed

Claesson M.J., Jeffery I.B., Conde S., Power S.E., O’connor E.M., Cusack S., Harris H.M., Coakley M., Lakshminarayanan B., O’Sullivan O. Gut microbiota composition correlates with diet and health in the elderly. Nature. 2012;488:178–184. doi: 10.1038/nature11319. - DOI - PubMed

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplements: Practitioner - Grade, Over The Counter (OTC), and Private Label. Which is better for you?

scott@skywax.com (Scott Lucas) — Thu, 23 Jun 2022 17:12:49 GMT

Supplements: Practitioner - Grade, Over The Counter (OTC), and Private Label.

Which is better for you?

When it comes to supplements, there are three main types: Practitioner-Grade, Over The Counter (OTC), and Private Label. So which one is the best for you? Let's take a closer look at each type.

Supplements 101

Practitioner-Grade supplements are those that can only be obtained through a healthcare Practitioner. They are generally more expensive than OTC supplements, but they also tend to be of higher quality. One of reasons that Practitioner-Grade supplements are so effective is that they are free of fillers, binders, and artificial components that may be found in many over-the-counter products. The source of the nutrients is also tested by a third party to assure purity and potency. Generally they ‘re more powerful and bioavailable, which means your body can absorb and use them better. Practitioner- Grade supplements are held to a higher standard than OTC ones. These supplements are also customized to meet your specific needs and they can meet the demands of your unique genetic makeup.

OTC supplements are those that can be purchased without a prescription. They are typically less costly than Practitioner-grade formulations, but they may not be as effective. OTC supplements are also not customized to meet your specific needs.

Private Label supplements are those that have been manufactured by a supplement company and then sold under a different firm's brand or name. However, unless they are produced by a reputable supplement company the quality can be questionable.

What is the best supplement for you?

So, which type of supplement is right for you? If you are looking for the highest quality supplement that is customized to meet your personalized needs, then Practitioner-Grade is the way to go. However, if you are on a budget, OTC supplements may be a good option. It's vital that you do your homework to ensure you're receiving a good product.

Generally speaking, Practitioner-Grade supplements are the best option for those looking to maintain and improve their health. They are more expensive, but they are also more effective and tailored to your individual needs. OTC supplements can be a good option for those on a budget, but they may not be as effective. Private Label supplements can be a good option, but the quality can vary greatly. Invest in a product that is well-made and reputable. Just double-check to make sure you're buying a quality supplement.

At Dr. Michael's Wellness , we did the research for you! We only recommend the best quality Practitioner-Grade supplements. Free from impurities, fillers, toxic metals, and additives, our products are backed by science and designed to help you reach your health goals. We only recommend Practioner-Grade products that have been third party tested and not been flagged by Consumer Lab which is an independent organization that tests supplements for safety and efficacy. So, you can be sure you are getting the best quality products available on the market.

As the name implies, this book will teach you how to unlock your genetic superpowers with nutrition, Practitioner-Grade supplements, and lifestyle.

For those who want to live a longer and healthier life, this book is a must-read! Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Dr. Marios Michael, DC, CNS, cFMP, 06/2022, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers, 1st edition, Austin, Bookbaby.

What You Need to Know about Dietary Supplements” FDA, November 29, 2017. https://www.fda.gov/food/buy-store-serve-safe-food/what-you-need-know-about-dietary- supplements

Steelsmith, Laurie, Dr. “Why Are Some Vitamins and Supplements More Expensive Than Others?” The Upside. https://www.vitacost.com/blog/are-expensive-vitamins-better/

Levin, Sasha. “What Are Binders and Fillers?” Purity Products, May 27, 2020. https://www.purityproducts.com/blog/binders-and- fillers

https://www.consumerlab.com/

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Antioxidant Support for Your DNA: How to Keep Your Genes Healthy

scott@skywax.com (Scott Lucas) — Wed, 22 Jun 2022 19:00:49 GMT

Antioxidant Support for Your DNA: How to Keep Your Genes Healthy

Your DNA is the recipe for your life. They play a significant role in determining who you are, what illnesses you are susceptible to, and what you might achieve. That's why it's so important to keep them healthy! One way to do that is by providing antioxidant support. In this blog post, we will discuss the importance of antioxidants for DNA health and give you some tips on how to get them into your diet. Stay tuned for more information on how to protect your genes!

Antioxidants 101

Antioxidants are molecules that are important for DNA health because they help to protect the cells from damage. Since our DNA is found within our cells, it's critical to keep the cells in good working order so that we may safeguard our DNA. This is especially important as we age because our cells can become more susceptible to damage over time. Antioxidants work by scavenging harmful toxins and free radicals that can cause cell damage. Free radicals are unstable molecules that can be generated by things like pollution, UV radiation, cigarette smoke, environmental factors, and exposure to toxins. They can cause damage to our cells, which can lead to disease.

ROS and Oxidative stress!

ROS, or reactive oxygen species, are molecules that contain oxygen and are highly reactive. These molecules can damage DNA, proteins, and lipids. Antioxidants are substances that can neutralize ROS and protect cells from oxidative stress.

Oxidative stress is one of the most damaging forces your cells can face. It's been linked to everything from cancer to Alzheimer's disease. It's comparable to how metal corrodes and food spoils. And while your body does have some mechanisms to protect itself from oxidative stress, those mechanisms can become overwhelmed. That's where antioxidants come in!

Between antioxidants and ROS, there must be a balance or a state of homeostasis. Too many or too few of either can induce oxidative stress, which may damage cells, proteins, and DNA.

There are many different antioxidants that you can get from foods and supplements. Endogenous antioxidants are those that are produced naturally by our bodies. Exogenous antioxidants are those that we get from external sources, such as food and supplements. Some of the most common endogenous antioxidants include glutathione, CoQ-10, and vitamins A, C, and E. You can also get these same nutrients from foods like fruits and vegetables which include blueberries, strawberries, and kale.

So, how can you get more antioxidants into your diet?

Here are some tips:

- Eat a variety of fruits and vegetables. This will ensure that you're getting a wide range of antioxidant nutrients.

- Choose organic produce whenever possible. This will help to reduce your exposure to toxins and pesticides.

- Supplement with a high-quality Practitioner-Grade antioxidant supplement

- This will help to fill in any gaps in your diet and provide you with an extra layer of protection.

Detox also aids in the removal of toxins, free radicals, and ROS from the body, which is beneficial to health and lowers disease risk.

Antioxidants for DNA health

Some of the most important ones for DNA health include vitamins C and E, beta-carotene, selenium, zinc, and CoQ-10. You can find these nutrients in a variety of foods, including fruits, vegetables, nuts, seeds, and whole grains. You can also get them from Practitioner-Grade supplements. If you are looking for an antioxidant supplement to support your DNA health, make sure to choose one that contains all of these nutrients!

Conclusion

Antioxidants are important for DNA health because they help to protect the cells from damage. ROS and oxidative stress can cause cell damage, which can lead to disease. You can get antioxidants from foods and supplements. To ensure that you're getting a wide variety of antioxidant nutrients, supplement with Practitioner- Grade supplements eat a variety of fruits and vegetables, and choose organic produce whenever possible and affordable.

If you’re interested in learning more about antioxidants and how to make your DNA work for you, check out chapter # 4 of my new book, Understanding Genomics ; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers.

For those who want to live a longer and healthier life, this book is a must-read! Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Richmond D.J. Sinding M.H.S. Gilbert M.T.P. The potential and pitfalls of de-extinction. Zool. Scr. 2016; 45: 22-36

Poinar H.N. Schwarz C. Qi J. Shapiro B. Macphee R.D. Buigues B. Tikhonov A. Huson D.H. Tomsho L.P. Auch A. et al. Metagenomics to paleogenomics: large-scale sequencing of mammoth DNA. Science. 2006; 311: 392-394

https://www.cbsnews.com/news/gene-editing-resurrect-extinct-christmas-island-rat-study/

https://www.cell.com/action/showPdf?pii=S0960-9822%2822%2900249-4

https://www.cbsnews.com/news/harvard-scientists-bringing-the-woolly-mammoth-back-from-extinction/

https://www.drmichaelswellness.com/dr-ms-book

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Bringing Extinct Species Back to Life: The Science of Jurassic Park

scott@skywax.com (Scott Lucas) — Tue, 21 Jun 2022 18:42:02 GMT

Bringing Extinct Species Back to Life: The Science of Jurassic Park

What if we could bring extinct species back to life? The science of Jurassic Park explores this possibility, and while it may seem like something out of a movie, there is actually some truth behind it. Scientists are studying ways to resurrect extinct species, and while there are many challenges to this process, the potential rewards are great. In this blog post, we will explore the science of Jurassic Park and discuss what it would take to bring extinct species back to life.

Resurrecting the extinct!

Resurrecting extinct species is not an easy task. It requires a lot of research and work to find the right DNA and to figure out how to recreate it. However, the potential rewards are great. If we could bring back extinct species, it would be like having a window into the past. We could learn so much about them and their ecology. Additionally, it would be a great way to preserve biodiversity. So, while the process is challenging, it is definitely worth pursuing.

CRISPR

CRISPR is a technology that is being used for a variety of applications, including resurrecting extinct species. CRISPR, short for Clustered Regularly Interspaced Short Palindromic Repeat, is gene-editing technology. It's high-tech DNA precision scissors or a scalpel that works on the molecular level. As a result, if we have the DNA of an extinct species, we may use CRISPR to modify it and make it viable again. This is a very exciting development, as it means that we can bring back extinct species.

The idea of resurrecting extinct species is not new. The ancient Greeks wrote about it and even attempted to do it themselves. In the early 1800s, French naturalist Georges Cuvier resurrect an animal he called a "living fossil." It was actually a hoax, but the idea caught on and has been popular ever since.

In 2013, scientists announced they had successfully resurrected the gastric-brooding frog, which went extinct in 1983. The team used genetic material from museum specimens to bring the species back to life. This is an incredible feat and offers hope that other extinct species may one day be resurrected.

Woolly mammoth

Currently, there are two projects to bring back the wooly mammoth and they are in the early stages. The first is led by a team of Russian and Japanese scientists who are working to resurrect the species using DNA from frozen woolly mammoth specimens. The second project is being led by a team of Harvard scientists who are hoping to use CRISPR technology to bring the species back to life.

Both projects are still in the early stages, but they offer hope that we may one day be able to resurrect extinct species. It is an incredible feat of science and offers us a glimpse into the future of what may be possible. Who knows, maybe one day we will even be able to bring back the dinosaurs!

Conclusion

There are many challenges to resurrecting extinct species, but the potential rewards are great. With continued research, we may be able to bring back some of the amazing creatures that have been lost to time.

What do you think about the possibility of resurrecting extinct species? Do you think it is something that should be done? Let us know in the comments below. Thanks for reading!

If you’re interested in learning more about resurrecting the extinct species and how to make your DNA work for you, check out my new book, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers.

For those who want to live a longer and healthier life, this book is a must-read! Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Richmond D.J. Sinding M.H.S. Gilbert M.T.P. The potential and pitfalls of de-extinction. Zool. Scr. 2016; 45: 22-36

Poinar H.N. Schwarz C. Qi J. Shapiro B. Macphee R.D. Buigues B. Tikhonov A. Huson D.H. Tomsho L.P. Auch A. et al. Metagenomics to paleogenomics: large-scale sequencing of mammoth DNA. Science. 2006; 311: 392-394

https://www.cbsnews.com/news/gene-editing-resurrect-extinct-christmas-island-rat-study/

https://www.cell.com/action/showPdf?pii=S0960-9822%2822%2900249-4

https://www.cbsnews.com/news/harvard-scientists-bringing-the-woolly-mammoth-back-from-extinction/

https://www.drmichaelswellness.com/dr-ms-book

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Your DNA is nature, your Epigenetics is nurture

scott@skywax.com (Scott Lucas) — Mon, 20 Jun 2022 16:44:39 GMT

Your DNA is nature, your Epigenetics is nurture

You've likely been told that your genes determine your overall health, how long you will live, or if you will develop a chronic illness. But what if I told you that your genes are NOT your destiny?

Thanks to Epigenetics, we have the power to turn specific genes on and off - keep reading to discover how!

What is Epigenetics?

Epigenetics is the study of how your environment and habits influence how your genes behave. While genes play an essential role in your health and wellness, so do your behaviors and lifestyle, like your diet and how often you exercise.

Genetic changes are irreversible, but epigenetic changes are reversible and do not change your DNA sequence. However, they can change how your body reads a DNA sequence.

One way to think of Epigenetics is in terms of nature versus nurture. Your DNA sequence represents nature, while your Epigenetics represents nurture. While DNA is important, how your DNA responds to the environment is just as critical.

Environmental factors affecting our genome

Epigenetic changes can impact gene expression, turning genes 'on' or 'off.' Unlike a mutation, which is a permanent DNA change, genes can encounter reversible changes, also known as epigenetic changes. These reversible changes are caused by lifestyle factors and habits, including:

Stress
Age
Lifestyle
Supplements
Food
Bacteria
Gut health
Lack of sleep
Lack of touch
Lack of exercise
Anxiety
Alcohol
High-fat diet
Sugar

DNA damage caused by the outside environment or exposure to certain chemicals can induce epigenetic changes. These are also referred to as exposomes. Exposomes are significant since they show how your genes react with the environment. Some examples of exposomes include:

Free radicals
Toxins
Ultraviolet radiation
Viruses
Chemicals
Infections

When your DNA is damaged, it can lead to changes in gene expression. These changes can be heritable, meaning they can be passed down from one generation to the next. This is one way that the environment can influence the genes of future generations.

How to turn your genes on or off

In one notable study, pregnant mice were exposed to bisphenol A, a chemical found in many plastic drink bottles, including baby bottles. The mice exposed to this chemical had an increased risk of obesity, showing that certain environmental factors, which in this case was exposure to a specific chemical, impacted their gene expression.

This scenario is just one example of an environmental factor that turned specific genes 'on.' Our genes take direction from our behaviors, environment, and habits. This is fantastic news because it shows us that we are in control of our genetic destiny!

In humans, many factors and habits can turn genes on and off. Here are a few ways to turn bad genes 'off,' and good genes 'on.'

Get more physical activity . Research has shown that physical activity can counteract the effects of a gene linked to obesity and diabetes.
Limit alcohol consumption . Alcohol consumption has been correlated with a higher risk of cancer.
Quit smoking . Like alcohol, tobacco has also been linked to higher cancer risk.
Avoid fried foods . One study found that high consumption of fried foods could interact with obesity-related genes, increasing your risk of obesity.

Your genes are NOT your destiny!

If you’re interested in learning more about epigenetics and how to turn your genes on and off, check out my new book, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers.

This book is a must-read if you want to learn how to control your genetic destiny! Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

How to Detox: The Ultimate Guide

scott@skywax.com (Scott Lucas) — Thu, 16 Jun 2022 17:00:46 GMT

How to Detox:

The Ultimate Guide

Do you feel like you're constantly tired and stressed? Do you have trouble losing weight, or feeling good in your own skin? If so, detoxing might be the solution for you! Detoxing is the process of removing toxins from your system, and it can have amazing benefits for your health. In this article, we will discuss the different ways to detox, as well as the benefits of doing so. We'll also provide a list of common toxins that can impact your health, and offer advice on how to detox them from your system. Are you ready to start feeling better than ever?

Let's get started!

There are a number of ways to detox your body, but the most efficient include using Practitioner-Grade supplements and medical food shakes, as well as adopting healthy lifestyle choices.

Detoxing can have a number of benefits for your health, including improved energy levels, better digestion, hormone balance, and reduced inflammation. Additionally, detoxing can help improve your skin health, and even lead to weight loss. If you're looking for a way to feel better and live a healthier life, detoxing might be the answer.

Let's get started with the fundamentals of detoxing now that you know what it is. So, what are some common toxins that can impact your health? Metal and non-metal toxins such as mercury, lead, cadmium, tin, and arsenic can all have negative effects on your health. Additionally, organophosphates can also be harmful. There are numerous toxins that can harm your health, but these are some of the most prevalent. If you're considering a detox, be aware of the various ways pollutants may enter your body. Heavy metal toxins, for example, can be found in drinking water, as well as in certain foods. Organophosphates are commonly used in pesticides, and can also be found in food and water. Non-metal toxins, such as mold and asbestos, can enter your system through inhalation.

So how do you detox from these toxins?

Detoxification therapy with Practitioner-Grade supplements or chelation therapy are used to bind heavy metals to molecules to flush them out of the body. Detoxing from organophosphates can be done through detoxification therapy, which helps to break down the toxins in your body so they can be eliminated. Last but not least, detoxing from non-metal toxins can be done through detoxification therapy, as well as by avoiding exposure to the toxin.

Where to start?

Looking to detox but not sure where to start? There are many different detox protocols and it can be tricky to know which one is right for you. When choosing a detox protocol, it's important to consider your specific goals. Are you looking to cleanse your system of fat and water-soluble toxins? Or are you hoping to lose weight? The cleanse we advised meets both of these objectives as well as many others. To assist you to detoxify your body and feel your best, we provide you with one of the most effective highly researched Practitioner-Grade detoxification therapy based on supplements and medical food shakes with a food detox guide program. In this guide ( 10 day and 28 day ), we'll show you how to detox your body safely and effectively, so that you can enjoy all the benefits of detoxing.

Click for the 10-Day Detox Program

https://mmichael.metagenics.com/item/bundxbphxglh/detox-10-days/1-practitioner.html

Click for the 28-Day Detox Program

https://mmichael.metagenics.com/item/bundud3nic3i/detox-28-days/1-practitioner.html

The recommended cleanse addresses all three stages of detox in one session.

- Preparation : This is the phase where you start to eliminate water toxins from your diet and make lifestyle changes to support detoxification.

- Detoxification : During this phase, your body eliminates water and fat-soluble toxins.

- Rejuvenation : This is the phase where you focus on rebuilding your health and supporting your body's natural detoxification process.

Detoxing can be a great way to improve your health and well-being, but it must be done safely and effectively. No matter what type of detox plan you choose it's important to make sure you're getting enough rest, drinking plenty of water, and eating a healthy diet. While you're cleansing, it's also essential to avoid processed meals, caffeine, and alcohol. These substances can actually make it harder for your body to detoxify itself. Detoxing may be a beneficial strategy to enhance your health, but it isn't a quick remedy. In order to see the best results, you need to commit to making healthy lifestyle changes that will last a lifetime. Please consult with your Primary Care Physician (PCP) before starting any detoxification protocol.

Conclusion

Now that you know how to detox, and what some of the most common toxins are, it's time to start feeling better! Detoxing can have a profound impact on your health and is a great way to improve your overall wellbeing. So what are you waiting for? Get started today!

If you're interested in learning more about detox, supplements, and how to utilize your DNA for your benefit, please read chapter # 4 of my new book, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers.

As the name implies, this book will teach you how to unlock your genetic superpowers with nutrition, Practitioner-Grade supplements, and lifestyle. For those who want to live a longer and healthier life, this book is a must-read!

Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

Lukaczer, Dan. Clinical Nutrition: A Functional Approach. Second Edition. The Institute of Functional Medicine. 2004.
Liska, DeAnn J. PhD., and Rountree, Robert, M.D. “The Role of Detoxification in the Prevention of Chronic Degenerative Diseases.” Applied Nutritional Science Reports, Advanced Nutrition Publications, Inc. 2002.
https://www.doctorsdata.com/comprehensive-drinking-water- analysis/
https://info.metagenicsinstitute.com/detox-hub

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

How Biological Age Affects Your Lifespan: Chronological vs. Biological Age

scott@skywax.com (Scott Lucas) — Wed, 15 Jun 2022 18:40:37 GMT

How Biological Age Affects Your Lifespan:

Chronological vs. Biological Age

Did you know that your chronological age is not always an accurate predictor of your biological age? In fact, many factors can affect your lifespan, including your lifestyle choices, environment, and even your mindset. In this blog post, we will discuss the differences between chronological age and biological age, and explore how you can take steps to improve your biological age.

What is biological age?

Biological age is the measure of how well your cells are functioning. This number can be affected by a variety of factors, including stress levels, diet, lack of quality intake of supplements, and exposure to toxins. Chronological age, on the other hand, is simply the number of years you have been alive.

One way to think about biological age is in terms of cellular health. Just as you can take steps to improve your physical health, you can also take steps to improve your cellular health. This includes things like eating a healthy diet, exercising regularly, and getting enough sleep. You can also support your cellular health with Practitioner-Grade supplement s that contain ingredients like resveratrol and CoQ-10. NAD+ (nicotinamide adenine dinucleotide) supplement is an excellent way to improve cellular health and biological age. NAD+ is required for life, and levels drop as we get older. It can activate Sirtuins, also known as "guardians of the genome" because of their role in protecting genome stability during stress response.

How to measure biological age

There are a number of ways to measure biological age. One popular method is telomere testing, which looks at the length of your telomeres. Telomeres are the protective caps at the end of your chromosomes, and they play an important role in cellular health. As we age, our telomeres shorten, so measuring their length can give us an indication of biological age.

If you want to know your biological age, there are a few different tests you can take. Functional Medicine doctors often use biological age tests ; to help their patients understand how well they are aging.

If your chronological age is significantly higher than your biological age, it's a good sign that you are taking care of yourself and doing things that support your health. On the other hand, if your biological age is much higher than your chronological age, it's a good idea to take steps to improve your cellular health. There are a number of ways to do this, and we will discuss some of them in future blog posts. Stay tuned!

It's never too late to start taking care of your cells, and doing so can help you live a longer, healthier life. So, if you're looking to reverse aging, focus on your biological age. With the right lifestyle choices and Practitioner-Grade supplements, you can improve your cellular health and extend your lifespan.

Conclusion

It's clear that chronological age and biological age are two very different things. Chronological age is simply a measure of time, while biological age is a measure of your cellular health.

So, what does this mean for you? Well, if you want to live a long and healthy life, it's important to focus on keeping your biological age as young as possible. This can be done through lifestyle choices like eating a healthy diet and exercising regularly, but it can also be accomplished by taking Practitioner-Grade supplements that support cellular health.

In short, don't let your chronological age dictate how you live your life. Instead, focus on keeping your biological age young, and you'll enjoy a longer, healthier lifespan.

What are your thoughts on biological age vs chronological age? Do you think one is more important than the other? Let us know in the comments below! Thanks for reading! And be sure to subscribe to our blog for more interesting articles about health and wellness

If you’re interested in learning more about biological age vs chronological age and how to make your DNA work for you, check out chapter # 9 of my new book , Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers.

As the name implies, this book will teach you how to unlock your genetic superpowers with nutrition, Practitioner-grade supplements, and lifestyle. For those who want to live a longer and healthier life, this book is a must-read!

Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

Resources:

https://www.drmichaelswellness.com/dr-ms-book

O’Connor, C. (2008). Telomeres of human chromosomes. Nature Education 1(1):166. https://www.nature.com/scitable/topicpage/telomeres-of-human-chromosomes-21041/

Beyer AM, Norwood Toro LE. Telomerase: Location, Location, Location? Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):1247- 1249. doi: 10.1161/ATVBAHA.118.311054. PMID: 29793988;

PMCID: PMC6028234. https://pubmed.ncbi.nlm.nih.gov/34140684/

Sahin E, Depinho RA. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature, 2010, Mar 25;464(7288):520-8. doi: 10.1038/nature08982. PMID: 20336134; PMCID: PMC3733214

“What is a telomere?” Your Genome, July 21, 2021. https://www.yourgenome.org/facts/what-is-a-telomere

"Telomere Analysis Technology. Results Report. Life Length, S.L. www.lifelength.com , January 17, 2018.

Dambeck, Susanne. “Ten Astonishing Facts about Longevity.” Lindau Nobel Laureate Meetings, October 11, 2016. https://www.lindau-nobel.org/ten-astonishing-facts-about-longevity

Bernardes de Jesus B, Vera E, Schneeberger K, et al. Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. EMBO Mol Med. 2012;4(8):691-704. doi:10.1002/emmm.201200245. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494070/

Genomics: How to Make Your Genes Work For YOU!

scott@skywax.com (Scott Lucas) — Mon, 13 Jun 2022 17:40:23 GMT

Genomics:

How to Make Your Genes Work For YOU!

Have you ever wondered what your genes say about you? What diseases you might be at risk for, or how you might respond to different treatments? Thanks to advances in Genomics, we can now begin to answer some of these questions. Genomics is making massive advances toward predicting, diagnosing, and treating diseases. So what does this mean for you?

Luckily, due to Genomics, preventing disease has never been easier! Keep reading for more information on how Genomics is changing the game for preventative healthcare and disease management.

What is Genomics?

The genome contains all the instructions and information needed for an organism to form, maintain itself, and function. We all have a copy of our own unique genome in every cell of our bodies. A proven saying in Biology is that an accumulation of cells makes tissues, a group of tissues makes organs and functionally related organs create our systems.

You probably have a general idea of the term Genetics, which is the study of the role of individual genes. Genomics is a similar concept, but instead of focusing on individual genes, it focuses on all the genes and environment together.

Genomics also includes the study of complex diseases and conditions, like asthma, cancer, heart disease, chronic kidney disease and diabetes. These issues are usually caused by a combination of genetic and environmental factors rather than the expression of individual genes.

Why is Genomics Important?

According to CDC, six in ten adults have a chronic condition and 4 in 10 adults have two or more. Genomics helps scientists and doctors better understand the cause of these severe and chronic diseases, it is essential for developing new therapies and medicines. Learning more about how our genes interact with each other and the environment is incredibly productive for developing new treatments and diagnostic tools. As a result, Genomics is playing a revolutionary role in disease management, prediction, and prevention.

Genomics is the gift that keeps on giving. But it’s not just Genomics that is revolutionizing modern medicine –– it’s all of the different “omics.” These include Pharmacogenomics (the study of the relationship between drugs and gene expressions) , Microbiomics (study of microbial cells), and Metabolomics (study of small molecules). While there are many other “omics”-related fields, they are all changing the landscape of how we look at disease. These fields of study allow us to create more efficient ways to manage conditions, prevent them from happening in the first place, and predict them long before symptoms have started.

What is Genomics Used for?

One form of Genomics, called Nutrigenomics, studies the relationship between nutrients, diet, and gene expression. Because of Nutrigenomics, we have discovered more about how our environment, food, lifestyle, and supplements have the potential to turn a protective or harmful gene on and off, silence it, slow it down, or increase its expression. Nutrigenomics has the groundbreaking potential to create personalized nutrition plans or treatment approaches that are truly individualized to the patient’s DNA.

For example, suppose you take a genomic test and discover that you are more susceptible to heart disease. In that case, you can prioritize your cardiovascular health throughout your life to better support your heart. Nutrigenomics can help you find the proper Practitioner-Grade supplements for your heart health or the best exercises and diet for your specific genome. You could also integrate lifestyle changes that have been proven to improve cardiovascular health, like practicing mindfulness and adopting the Mediterranean diet.

Genomics offers the opportunity for personalized precision medicine , considering the patient’s genetic traits, symptoms, and severity to create the best treatment plan or preventative care for their condition.

Who is Genomics for?

Genomics is for everyone! We can all benefit from learning more about how our genes function together and how our environment and lifestyle influence them. The fact that we can control and impact how our genes express health and wellness is excellent news!

If you’re interested in learning more about genomics and how to make your DNA work for you, check out my new book, Understanding Genomics; How Nutrition, Supplements, and Lifestyle Can Help You Unlock Your Genetic Superpowers.

Order a copy today!

Until then, stay healthy and happy!

Dr. Marios Michael

drmichaelswellness.com

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.